All issues > Volume 31(5); 1988

Original Article

J Korean Pediatr Soc. 1988;31(5):621-626. Published online May 31, 1988.

A Case of Pulmonary Candidiasis.

Hye Ran Byun¹, Kung Ha Ryu¹, Moon Ja Kim¹, Keun Lee¹, Yeon Lim Suh², Je Geun Chi²

¹Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea
²Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea

Received: September 23, 1987;  Accepted: December 23, 1987.

Abstract

A case of fatal pulmonary candidiasis was diagnosed at autopsy of 5-month-old female infant. Patient had mild coughing, poor weight gain and marked hepatosplenomegaly. She had no sign of immune dysfunction but developed fever, wheezing and intermittent respiratory distress. Chest P-A showed infiltrations of multiple lobar pneumonia. Postmortem examination revealed the whitish necrotic mass like lesion with a feature of lobar pneumonic consolidation in the right lung and the upper lobe of the left lung. There were numerous small cystic spaces mimiking a honeycomb scattered within the necrotic lesion. Microscopically the lesions consisted of exuberant necrotizing granulomas and fibrosis. Periodic acid-Schiff and Methenamine Silver stains showed small numbers of round to oval shaped, yeast like organisms mixed with pseudohyphae in the necrotic center of the granulomas. The liver was markedly enlarged and showed early cirrhotic change of micronodular type, together with acinar arrangement of hepatocytes and bile plugging, and cholestasis.

Keywords :Pulmonary candidiasis