All issues > Volume 32(11); 1989

Original Article

J Korean Pediatr Soc. 1989;32(11):1574-1580. Published online November 30, 1989.

Two cases of Glanzmann's thrombasthenia in brother.

Won Mo Yang¹, Hyung Kook Ham¹, Mee Kyung Namgoong¹, Baek Keun Lim¹, Hong Sup Yoon², Kab Joon Yoon²

¹Department of Pediatrics, Wonju College of Medicine, Yonsei University Wonju, Korea
²Department of Clinical Pathology, Wonju College of Medicine, Yonsei University Wonju, Korea

Received: May 17, 1989;  Accepted: August 9, 1989.

Abstract

Glanzmann’s thrombasthenia is rare congenital bleeding disorder of autosomal recessive trait. We experienced two cases of Glanzmann’s thrombasthenia in brother. The mother and elder brother had no history of bleeding tendency. But 10 year-old and 7 year-old younger brothers had frequent epistaxis, gum bleeding and easy bruisability. On platelet aggregation test, mother and elder brother appeared normal responses, but the younger brothers appeared no responses to ADP, epinephrine and collagen, with normal response to ristocetin. We report two cases of Glanzmann’s thrombasthenia in brother with review of literatures briefly.

Keywords :Glanzmann’s thrombasthenia, Platelet aggregation test