All issues > Volume 46(12); 2003

Case Report

J Korean Pediatr Soc. 2003;46(12):1279-1282. Published online December 15, 2003.

A Therapeutic Experience of Congenital Bilateral Neuroblastoma

Yeon Kyong YK Seo¹, Heung Sik HS Kim¹, Kun Young KY Kwon², Hee Jung HJ Lee³, Hong Hoe HH Koo⁴

¹Department of Pediatrics,School of Medicine, Keimyung University, Daegu, Korea
²Department of Pathology, School of Medicine, Keimyung University, Daegu, Korea
³Department of Radiology, School of Medicine, Keimyung University, Daegu, Korea
⁴Department of Pediatrics, School of Medicine, Sungkyunkwan University, Seoul, Korea

Correspondence Heung Sik HS Kim ,Email: kimhs@dsmc.or.kr

Abstract

Neuroblastoma is the most common intraabdominal malignant tumor of childhood, with 40% arising from the adrenal gland. Bilateral adrenal involvement from synchronous development or metastatic spread of tumor is rarely seen in children with neuroblastoma. The patient was born with a spontaneous vaginal delivery. Birth weight was 3,200 g. Fetal ultrasonography showed a left adrenal cystic mass. At two weeks of age, she was admitted due to a massive abdominal distension and tachypnea. Percutaneous ultrasonography guided biopsy of the left adrenal mass was performed. The result of the biopsy was neuroblastoma. Vincristine and cyclophosphamide were administerd intravenously and 450 cGy of irradiation was added. Left adrenalectomy was accomplished and postoperative course was uneventful. The patient received cancer chemotherapy with a combination of carboplatin, ifosfamide and VP-16 and is now being followed up for three months. We have experienced a case of congenital bilateral neuroblastoma and report the case with brief review of related literatures.

Keywords :Congenital neuroblastoma, Bilateral neuroblastoma