All issues > Volume 46(10); 2003

Case Report

J Korean Pediatr Soc. 2003;46(10):1029-1031. Published online October 15, 2003.

A Case of Hemophagocytic Lymphohistiocytosis in a Child with Systemic Lupus Erythematosus

Ja Young JY Hwang¹, Suk Man SM No¹, Jin J Lee¹, Pil Sang PS Jang¹, Young Hoon YH Kim¹, Jin Tack JT Kim¹, Joon Sung JS Lee¹

¹Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea

Correspondence Jin Tack JT Kim ,Email: jintackk@catholic.ac.kr

Abstract

Hemophagocytic lymphohistiocytosis is a reactive disorder characterized by a generalized non-malignant histiocytic proliferation with prominent hemophagocytosis by stimulated histiocytes in the bone marrow and reticuloendothelial systems resulting in pancytopenia and liver dysfunction. Several diseases including infection, malignancy and autoimmune disease are known to be causative disorders. This case demonstrated histiocytic hemophagocytosis in the bone marrow, resulting in pancytopenia during treatment of systemic lupus erythematosus and did not show any underlying disease.

Keywords :Hemophagocytic lymphohistiocytosis, Systemic lupus erythematosus