All issues > Volume 43(6); 2000

Case Report

J Korean Pediatr Soc. 2000;43(6):861-865. Published online June 15, 2000.

A Case of Neonatal Alloimmune Thrombocytopenia due to Anti-HLA A2

Sung Young SY Kim¹, Eun Ryoung ER Kim¹, Young Jin YJ Kim², Myoung Hee MH Park³, Eun Young EY Song³, Kyou Sup KS Han³

¹Department of Pediatrics, Sung-Ae General Hospital, Korea
²Department of Clinical Pathology, Sung-Ae General Hospital, Korea
³Department of Clinical Pathology, Seoul National University College of Medicine, Korea

Abstract

Neonatal alloimmune thrombocytopenia(NAIT) is a rare disease caused by maternal alloimmunization against fetal platelet surface antigen, which is mainly platelet specific alloantigen or human leukocyte antigen(HLA). During routine hemotology, we accidentally discovered thrombocytopenia in a female fullterm newborn admitted due to jaundice. We excluded NAIT due to human platelet alloantigen(HPA), because the HPA of the mother and baby were the same on PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism). Mother's serum was tested for lymphocytotoxity against 36 donor lymphocytes, and anti-HLA A2, A24 and B58 were found. HLA typing of the father and baby revealed A2 antigen which was not present on the mother's lymphocytes. The patient received concentrated platelet and intravenous globulin. Her platelet count increased to 222,000/mm3 from 3,000/mm3 on the 11th day of life. We described a case of NAIT due to anti-HLA A2 antibody with a detailed clinical feature.

Keywords :Neonatal alloimmune thrombocytopenia(NAIT), Anti-HLA A2 antibody, Newborn