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Can central venous access device care bundles and regular feedback reduce central line-associated complications in pediatric patients?

Can central venous access device care bundles and regular feedback reduce central line-associated complications in pediatric patients?

Article information

Clin Exp Pediatr. 2021;64(3):123-129
Publication date (electronic) : 2020 July 14
doi : https://doi.org/10.3345/cep.2020.00143
Division of Pediatric Critical Care, Department of Pediatrics, Faculty of Medicine, Thammasat University, Prathumthani, Thailand
Corresponding author: Chanapai Chaiyakulsil, MD. Division of Pediatric Critical Care, Department of Pediatrics, Faculty of Medicine, Thammasat University. 95 Phahol Yothin Road, Klong-Neung, Klong-Luang, Prathumthani 12120, Thailand Email: chanapai.chai@hotmail.com
Received 2020 January 27; Revised 2020 June 9; Accepted 2020 June 23.



The use of indwelling central venous access devices (CVADs) in children can result in complications such as infection, occlusion, and dislodgement.


To evaluate whether reinforcing CVAD care bundles by using a regular direct feedback system could reduce such complications in children.


The intervention in this retrospective interrupted time-series study was initiated in January 2019. The study was divided into the preintervention (October–December 2018), 3-month postintervention (January–March 2019), and 6-month postintervention (April–June 2019) phases. Risk difference and Poisson regression analyses were used to illustrate the effectiveness of the intervention.


The hospital-wide central line-related bloodstream infection rate decreased from 10.0/1,000 catheter-days to 4.5/1,000 catheter-days at 3-month postintervention (P=0.39) and to 1.4/1,000 catheter-days at 6-month postintervention (P=0.047). The central line occlusion rate significantly decreased from 30% to 12.8% (P=0.04) and 8.3% (P=0.002) at 3 and 6 months, respectively. Approximately 7% of CVADs became dislodged during the preintervention phase versus 8.5% (P=0.364) and 3.3% (P=0.378) at 3 and 6 months, respectively.


Reinforcing CVAD care bundles with direct feedback could significantly decrease CVAD-associated complications in terms of infection at 6-month postintervention, and occlusion at 3- and 6-month postintervention. Thus, reinforcement and regular direct feedback might improve care quality in children with CVADs.

Key message

Question: Can central line bundles and feedback reduce central line-associated complications in pediatric patients?

Finding: The central line-related bloodstream infection rate decreased from 10.0 catheter-days to 1.4/1,000 catheter-days at 6-month postintervention. The central line occlusion rate was also decreased.

Meaning: Reinforcing central line care bundles with direct feedback can significantly decrease central line-associated complications in pediatric patients.

Graphical abstract


Central venous access devices (CVADs) play an integral role in the medical management of many pediatric conditions [1,2]. It provides an efficient delivery of antibiotics, chemotherapy, parenteral nutrition, and other lifesaving medications which require large-caliber vessels to avoid vascular irritation and drug extravasation. Furthermore, central venous access also provides an access route for lifesaving interventions such as hemodialysis and plasmapheresis [3,4]. Despite its usefulness, indwelling CVADs can result in several possible complications such as central line-associated bloodstream infection (CLABSI), central line-related bloodstream infection (CRBSI), central line occlusion, deep vein thrombosis, or line dislodgement [1,2,5]. These complications lead to longer hospital stays and higher medical costs [1,2,5,6]. Approximately 250,000 CLABSIs occurred in United States hospitals each year with a mortality rate as high as 25% [7-9]. The estimated cost of treatment ranges from $5,821 to $60,536 per event [10,11]. From the current systematic review in pediatrics by Ullman et al. [2], it revealed that about 25% of CVADs failed before completion of treatment. CLABSI were found to occur in 10.3% of all catheters with an incidence rate of 1.4–1.86 episodes/1,000 catheter-days. A total of 7.4% and 4.7% of all catheters were found to have occlusion and dislodgement, respectively. As of present, there were only 2 single-center studies reporting central line complications in pediatrics in Thailand, which demonstrated an infection rate of 2.6–7.5 episodes/1,000 catheter-days [12,13]. These figures demonstrated that Thailand had higher infection rates when compared to that of the current systematic review. Many studies were previously done in the utilization of CVADs care bundles in order to reduce CVADs associated infection which resulted in favorable outcomes [1,7,9,13-17].

Nevertheless, most studies were conducted in developed countries such as the United States, Australia, Europe, or developed Asian countries and mostly aimed for reduction of infection rather than other complications such as occlusion or line dislodgement. Furthermore, most studies concentrated on the implementation of bundles rather than reinforcing the bundles with regular review and feedback. By using reinforcement and a direct feedback system, it may enhance the compliance of the bundles and provides early intervention for any altercation that may occur during CVADs care. Moreover, many of the studies focused on specific groups of patients such as oncology patients and critically ill children.

Thus, the objectives of this study were to determine the incidence of CVADs associated complications in terms of infection, central line occlusion, and dislodgement and to determine whether reinforcement of care bundles and direct feedback could reduce such complications. This study included hospitalwide children receiving CVADs and not restricted to only critically ill children and oncology patients.


1. Study design

This study was conducted in a retrospective, interrupted time-series fashion. The Ethics Committee of Thammasat University Hospital approved this research (IRB number: MTU-EC-PE 0-128/62) and informed consent was waived due to the retrospective nature of the study.

2. Participants

All children from neonates to 15 years old who received CVADs insertion from October 2018 to June 2019 at Thammasat University Hospital (TUH), Thailand except neonates who received peripherally inserted central catheter (PICC) insertion were included for analysis. Neonatal PICC was specifically cared for by neonatologists using different bundles. TUH is a large tertiary, university hospital which received at least 400 admissions in all pediatric wards per month. Approximately 15–20 CVADs were inserted per month.

3. Intervention

As a standard in our center, all CVADs access were performed by pediatric intensivists, interventional radiologist, or anesthesiologists who specialize in pediatric vascular access using ultrasound-guided venipuncture with modified Seldinger technique under maximal barriers. The choice of CVADs type (nontunneled catheter, PICC, or tunneled catheter [Broviac, Bard Peripheral Vascular Inc., Arizona, USA]) to be implanted were chosen at the time of consultation depending on the indication of CVADs and expected duration of utilization. Patients requiring intravenous access for more than 2 weeks would be chosen to implant PICC rather than nontunneled catheter. Internal jugular vein was a preferable site of insertion compared to the femoral vein. In Thailand, sutureless securement devices were not readily available, thus nylon 3-0 suture was used for securement.

CVADs care bundles were first implemented at TUH in 2014. As a quality improvement project of the hospital, a revised version of CVADs care bundles and a new system of regular direct feedback on CVADs care were implemented in January 2019. Revised CVADs care bundles were described in Table 1 using the HOPERD acronym.

Central venous access device (CVAD) care bundles using the HOPERD acronym

The bundles’ compliance and direct feedback were reinforced by a multidisciplinary vascular access team. The team encompassed of pediatric nurses who specialized in pediatric vascular access care, general pediatric nurses, and pediatric intensivists. Each team member underwent standardized training with bundles protocols in terms of tubing changes, dressing changes, and line access for blood draws and medications. Multidisciplinary team rounds were done on a weekly basis on every CVADs in the hospital. The team provided direct, constructive feedback for the improvement of CVADs care to general nurses and residents who were responsible for the CVADs care on a daily basis. During the rounds, the performance of the CVADs care along with bundles compliance was assessed by the team along with the necessity of CVADs access. Discussion was made upon the expected duration of CVADs utilization in each case. If the period of utilization was expected to be more than 2 weeks, the team would suggest a possible transition from a nontunneled catheter to a more permanent catheter. The suggestion of line removal was also given by the team if the indication for CVADs access was not fulfilled. After rounds, general nurses, residents, and the vascular access team meet for debriefing. During the debriefing, verbal feedback on the flushing technique and wound dressing were given. Tubing changes techniques, line access techniques for medications, and blood draw were also reviewed if mistakes were detected during rounds. Strict hand hygiene practice was encouraged during rounds and debriefing. The team also provided 24-hour availability for consultation.

4. Terminology of complications

1) Infection

(1) Central line-associated bloodstream infection (CLABSI) [18]

a recovery of a pathogen from blood culture in patients who had indwelling CVADs at the time of infection or within 48 hours before the development of infection. Only single positive blood culture was needed for organisms not commonly present in the skin, but 2 or more positive blood cultures were needed for common skin organisms. This should not be an infection related to another site.

(2) Central line-related bloodstream infections (CRBSI) [19]

Isolation of the same pathogen from blood culture drawn through the central line and from a peripheral vein

① With bacterial colony count at least threefold higher in the sample from the central line as compared to that obtained from the peripheral vein.

② Shorter time to positive culture in central line compared to that of the peripheral line (>2 hours earlier).

This study would use CRBSI incidence rather than CLABSI. If the patient had a positive culture from only either central line or peripheral vein, the diagnosis of contamination and septicemia would be given respectively instead of CRBSI.

2) Occlusion [20]

(1) Partial occlusion: where blood could not be aspirated but infusion was still possible

(2) Complete occlusion: inability to both aspirate and infuse blood or medications within that catheter.

As of this study, only complete occlusion of any lumen in a catheter would be considered.

3) Dislodgement

(1) Unintentional removal of CVADs by either a patient or a provider.

(2) This can be detected by visualizing a tip of the catheter outside the patient’s body

5. Data collection

Data from October to December 2018 was served as a preimplementation period and data from January to June 2019 was considered as a postimplementation phase. The data in the postimplementation period was analyzed every 3 months for 2 time periods (January to March 2019 and April to June 2019) for evaluation of possible improvement. All demographic data and complications in terms of infection, occlusion, and dislodgement were recorded.

6. Statistical analyses

Demographic data were illustrated using descriptive statistics. CRBSI rate was described using an event per 1,000 catheterdays. Complete occlusion, as well as dislodgement rate, were demonstrated using percent per total catheter used. Risk regression analyses, Poisson regression analysis, incidence rate ratios (IRR), and 95% confidence interval (95% CI) were used in the assessment of the effectiveness of the intervention. All statistical analyses were performed using IBM SPSS Statistics ver. 24.0 (IBM Co., Armonk, NY, USA) and Stata ver. 15 (StataCorp LLC, College Station, TX, USA).


1. Study population

A total of 152 catheters were utilized throughout the study period. The mean age of the whole cohort was 2.8 years old with the average time for catheter use of 13.4 days (range, 1–134 days). Children with underlying congenital heart diseases such as ventricular septal defect, double outlet right ventricle, and Tetralogy of Fallot contributes to about one-third of the catheters utilized in this cohort. Twenty-seven catheters (17%) were utilized in children with congenital heart diseases who required cardiac surgery. These were categorized under postoperative in Table 2. Inotropy was the most common indication for CVADs access. Most commonly utilized CVADs were nontunneled catheter (>90%). About 80% of patients were admitted in the intensive care unit during CVADs access. The demographic data for each period were summarized in Table 2. Half of the CVADs insertions were performed under emergency settings where patients required prompt intravenous access for resuscitation and inotropic support (Table 3).

Patients’ demographic data

Total catheter days and incidence of central venous access device-associated complications by study period

2. Infection

After the intervention, CRBSI decreased from 10.0/1,000 catheter-days to 4.5/1,000 catheter-days during the first 3 months (IRR, 0.49; 95% CI, 0.10–2.44; P=0.39). During the 4th to 6th months of the study, the rate significantly de-escalated to 1.4/1,000 catheter-days (IRR, 0.08; 95% CI, 0.01–0.965; P< 0.05) (Table 3). CRBSI pathogens consist of both gram-negative pathogens such as Acinetobacter species, Enterobacter, and Klebsiella pneumoniae as well as gram-positive pathogens such as Enterococcus and Staphylococcus. Numbers of emergency CVADs access were not significantly different among periods (Table 3). Emergency CVADs and intensive care unit admission were not associated with an increasing rate of CRBSI (P>0.05).

3. Occlusion

CVADS complete occlusion rates significantly declined from 30% during preintervention period to 12.8% (percent reduction, 17.2%; 95% CI, 7.9%–34.1%; P=0.04) and 8.3% (percent reduction, 21.7%; 95% CI 7.9–36.3; P=0.002) at 3- and 6-month postintervention, respectively (Table 3). The hematologic characteristics of the patients among each period were not statistically different.

4. Dislodgement

The dislodgement rates were not significantly altered by the intervention. During the preintervention phase, approximately 7% of CVADs was dislodged compared with 8.5% at 3- month postintervention (percent increment, 1.5%; 95% CI, -6.7% to 18.3%; P=0.364) and 3.3% at 6 months (percent reduction, 3.7%; 95% CI, -12.1% to 4.6%; P=0.378) (Table 3)


Our study showed that the rate of CVADs associated complications, especially CRBSI and occlusion, declined after the reinforcement of bundles with regular feedback. The longest duration without CRBSI in our cohort was 106 days. According to the Center for Disease Control and Prevention (CDC), CLABSI and CRBSI were used interchangeably in the literature. CRBSI is a clinically adopted definition used for diagnosis and treatment of patients which requires specific laboratory testing to identify the catheter as the source of bloodstream infection. CLABSI is a term used by CDC to serve as a simpler definition for surveillance purposes. CLABSI is defined as a laboratory-confirmed bloodstream infection with a recovery of the pathogens in the bloodstream of the patients who had central line at the time of infection or within 48 hours before the development of infection. Since patients who had indwelling catheters within 48 hours could have bloodstream infections from other causes rather than central line-associated infection alone, thus overestimating the true incidence of CVADs infection. Therefore, in order to define infection specific to that of CVADs, this study used CRBSI incidence rather than CLABSI [18,21].

Albeit no statistically significant reduction of CRBSI at 3 months postintervention, there was 51% reduction in CRBSI rate. By reimplementation of the bundles and regular direct feedback along with the multidisciplinary team approach in tackling CVADs associated complications, it had been revealed by our nursing staffs on increasing compliance with the bundles leading to a significant decrease in CRBSI at 6-month postintervention and occlusion at both 3- and 6- month postintervention. This coincided with the study by Duffy et al. [22] and McMullan et al. [23] that demonstrated the usefulness of bundles reinforcement on compliance of CVADs care which ultimately resulted in a fall of complication rates.

This study was one of the first studies in Asia in evaluating the effectiveness of care bundles reinforcement with regular feedback on other CVADs complications rather than infection alone. Furthermore, our study also demonstrated the effectiveness of the intervention on a wider range of patients not restricting to critically ill or oncology patients. CRBSI and occlusion rates may vary upon patients’ severity and hematologic characteristics. Despite the fact that 80% of CVADs access was performed in the intensive care unit, only 50% require emergency access. Some of CVADs access were done in stable patients requiring parenteral nutrition. Patient’s severity and hematologic characteristics were similar among each period. Our results agreed with a large meta-analysis by Ista et al. [9] that CVADs bundles can reduce the risk of central line-associated infections in pediatric populations (IRR, 0.47–0.58).

In terms of dislodgement, we found no statistically significant increase in the incidence during the first 3 months of the intervention. The multidisciplinary team meeting was done and found that most dislodgement occurred in children with neurologic and behavioral problems who were unable to control impulse and behavior. Thus, we executed applications of hand restraints with gloves or pads in these high-risk patients for prevention of auto-removal of the catheters.

There were several limitations to this study. Since this was a single-center study, the results might not be generalizable to other centers with different levels of facilities. Furthermore, due to the small sample size of the population, it revealed a nonsignificant reduction of CRBSI at 3-month postintervention with wide 95% CI. Moreover, since this study was conducted in only 6-month period postintervention, it might not reveal the true effectiveness of the intervention as well as the sustainability. A long-term, large multicenter study with different levels of facilities should be conducted to further strengthen the effectiveness of reinforcement of care bundles and regular feedback on CVADs complications.

In conclusion, reinforcement of CVADs care bundles and direct feedback can significantly decrease CVADs associated complications in terms of infection at 6-month postintervention and occlusion at both 3- and 6-month postintervention. Reinforcement and regular direct feedback might be useful in improving the quality of care in children with CVADs.


No potential conflict of interest relevant to this article was reported.


The authors would like to show appreciation to all the residents, faculties and nursing staff of the Department of Pediatrics, Faculty of Medicine, Thammasat University Hospital for the strong support and extensive cooperation in making this quality improvement project possible and successful. The authors would also like to thank Assistant Professor Prapasri Gulalert, Department of Epidemiology, Faculty of Medicine, Thammasat University for statistical assistance. The authors would also like to thank Dr. Rapee Opasatian for the support and graphical assistance.


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Article information Continued

Table 1.

Central venous access device (CVAD) care bundles using the HOPERD acronym

CVADs care bundles HOPERD technique
H Hand hygiene
O Observe insertion site for abnormalities such as pain, erythema, or signs of infection
P Prevention of occlusions
Intermittent use of CVADs
- SASH techniques (saline, administration, saline, heparin)
- Flush NSS at least 3–5 mL or until the lumen is clear of blood clot and residues
- Lock the lumen with heparin 50 unit/mL 2 mL in a child >3 kg or heparin 4 unit/mL 1.5 mL in a child <3 kg with positive pressure technique
Continuous use of CVADs
- Heparin should be mixed with TPN at the mixture rate of 0.5–1 unit/mL of TPN
- Flush NSS 10 mL every 24 hours or upon changing the IV set
- Always for check for drug compatibility for prevention of precipitation
E Evaluate of lesion and dressing
- Aseptic technique with sterile gloves with 2% Chlorhexidine in 70% alcohol
- Perform the first dressing within the first 24 hours of insertion to check for bleeding
- Regular dressing every 7 days with semi-permeable dressing to remain the site clean, dry and intact
- If the site is dirty, wet or the dressing is not intact, dressing should be done immediately
- Daily review of the indication of CVADs utility
R Replacement of set
- ntravenous fluids without medication should be changed every 96 hours.
- Intravenous fluids with medications set should be changed every 24 hours
- TPN and fat infusion set should be changed every 24 hours
- Blood components infusion set should be changed every 4 hours
D Displacement
- Check the position and suture of CVADs every 8 hours

Table 2.

Patients’ demographic data

Variable Preinter-vention period (N=43) 3-Month postinter-vention (N=47) 6-Month postinter-vention (N=62)
Age (yr) 3.19±10.15 3.06±8.06 2.53±7.72
Male sex 18 (41.9) 24 (51.1) 34 (54.8)
Underlying diseases
 Cardiology 12 (27.9) 18 (38.3) 21 (33.9)
 Pulmonology 7 (16.3) 1 (2.1) -
 Neurology - 4 (8.5) 7 (11.3)
 Nephrology 6 (14.0) - 3 (4.8)
 Preterm 5 (11.6) 2 (4.3) 4 (6.5)
 Allergy 3 (7) 2 (4.3) -
 Gastrointestinal 2 (4.6) 3 (6.4) 4 (6.5)
 Hematology and oncology 1 (2.3) 5 (10.6) 3 (4.8)
 Genetic 1 (2.3) 5 (10.6) 10 (16.1)
 None 6 (14.0) 7 (14.9) 10 (16.1)
Admission diagnosis
 Cardiology 13 (30.2) 17 (36.2) 24 (38.7)
 Postoperative 5 11 11
 Congestive heart failure 3 5 5
 Pulmonary hypertensive crisis 1
 Hypoxic spell 1
 Total anomalous pulmonary venous return with obstruction 1
 Transposition of great arteries with cardiac arrest 1
 Post cardiac arrest 4
 Hypoxic spell 1
 Cardiogenic shock 2
 Shunt obstruction 1
Pulmonology 9 (20.9) 8 (17.0) 6 (9.7)
 Pneumonia 3 2 2
 Invasive pulmonary aspergillosis 3
 Laryngomalacia 2
 Pulmonary mass 1
 Tracheitis 1 1
 Acute respiratory distress syndrome 1 4
 Upper airway obstruction 1
 Bronchopulmonary dysplasia with spell 1
 Bronchopulmonary dysplasia 1
Gastrointestinal 8 (18.6) 4 (8.5) 9 (14.5)
 Corrosive ingestion 1
 Gastroschisis 2 1
 Hemoperitoneum 1
 Hypertrophic pyloric stenosis 1
 Necrotizing enterocolitis 2 3
 Severe diarrhea with shock 1
 Gastric volvulus 2
 Gastroesophageal reflux disease 1 1
 Upper gastrointestinal hemorrhage 1 1
 Gastric outlet obstruction 1
 Blunt abdominal trauma 1
 Midgut volvulus 1
Infectious disease 6 (14.0) 6 (12.8) 7 (11.3)
 Septic shock 6 6 6
 Dengue shock syndrome 1
Neurology 3 (7.0) 3 (6.4) 5 (8.1)
 Encephalitis 1 2
 Intracerebral hemorrhage 1 1
 Meningitis 1
 Hypoxic ischemic encephalopathy 2
 Pineal gland tumor 1
 Status epilepticus 1
 Meningomyelocele 1
Nephrology 3 (7.0) 4 (8.5) 3 (4.8)
 End-stage renal disease 3
 Hypertensive urgency 1
 Nephritonephrotic syndrome 1
 Rapidly progressive glomerulonephritis 1
 Urinary tract infection 1 1
 Hypernatremia 1
 Pseudohypoaldosteronism 1
Allergy/rheumatology 1 (2.3) 1 (2.1) -
 Eosinophilic esophagitis 1
 Polyarteritis nodosa 1
Hematology and oncology - 4 (8.5) 5 (8.1)
 Factor 7 deficiency 1 1
 Lymphoma 1
 Germ cell tumor 2
 Gluteal mass 1
 Osteosarcoma 1
 Teratoma 1
 Acute lymphoblastic lymphoma 1
Genetic - - 3 (4.8)
 Glycogen storage disease 1
 Methylmalonic acidemia 2
 Lack of peripheral access 16 (37.2) 15 (31.9) 19 (30.7)
 Inotropy 17 (39.5) 25 (53.3) 34 (54.8)
 Extracorporeal 3 (7.0) 1 (2.1) -
 Prolonged antibiotics 7 (16.3) 5 (10.6) 7 (11.3)
 Chemotherapy - 1 (2.1) 2 (3.2)
Type of CVAD
 Nontunneled catheter 39 (90.7) 44 (96.7) 60 (96.8)
 PICC 1 (2.3) 1 (2.1) 1 (1.6)
 Dialysis catheter 3 (7.0) 1 (2.1) -
 Tunneled catheter - 1 (2.1) 1 (1.6)
Site of CVAD insertion
 Pediatric intensive care unit 27 (62.8) 31 (65.9) 38 (61.3)
 Neonatal intensive care unit 8 (18.6) 3 (6.4) 9 (14.5)
 General ward 4 (9.3) 3 (6.4) 2 (3.2)
 Operating room 4 (9.3) 10 (21.3) 13 (21.0)

Values are presented as mean±standard deviation or number (%).

CVAD, central venous access device; PICC, peripherally inserted central catheter.

Table 3.

Total catheter days and incidence of central venous access device-associated complications by study period

Variable Preintervention period (N=43) 3-Month postintervention (N=47) 6-Month postintervention (N=62)
Mean catheter days (range) 13.9 (1–80) 14.1 (1–134) 12.3 (1–75)
Emergency CVAD 24 (55.8) 22 (46.8) 34 (54.8)
CRBSI, n (%) 6 (14.0) 3 (6.4) 1 (1.6)*
CRBSI rate (per 1,000 catheter-days) 10.0 4.5 1.4*
CRBSI pathogens
Acinetobacter Baumanii 1 1 1
Acinetobacter petii 1 - -
Bacillus cereus 1 - -
Enterobacter cloacae - 1 -
Enterococcus faecalis 1 - -
Klebsiella pneumoniae 2 - -
Staphylococcus capitis - 1 -
Total occlusion, n (%) 13 (30) 6 (12.8)* 5 (8.5)*
Dislodgement, n (%) 3 (7) 4 (8.5) 2 (3.3)

CVAD, central venous access device; CRBSI, catheter-related bloodstream infections.


P<0.05 compared to baseline.