| A case of idiopathic precocious puberty treated with a luteinizing hormone relaeasing hormone analog. |
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Keun Hee Chung, Yoo Mi Kim, Mi Won Kim, Soon Ki Kim, Moon Soo Park, Jin Keun Chang |
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Department of Pediatrics, Han II Hospital, Seoul, Korea |
| 특발성 진성 성조숙증에 있어서 황체형성호르몬 유리호르몬
유사물질에 의한 치험 1례 |
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정근희, 김유미, 김미원, 김순기, 박문수, 장진근 |
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한일병원 소아과 |
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Received: 16 August 1990 • Accepted: 24 October 1990 |
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| Abstract |
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We experienced a 4 year girl with idiopathic precocious puberty treated with a long acting LHRH
analog (Buserelin). As an indction therapy she received LHRH analog for 6 months in subcutaneous
route. After then she was maintained by intranasal therapy for 6 months. One month after the
induction therapy began, we observed prepunbertal pattern of LHRH stimulation test and significant
suppression of 17B-estradiol level. These hormonal responses were maintained after switching to
intranasal therapy except slightly increased 17B-Estradiol. We also observed significant deceleration
of growth velocity and bone maturation rate as well as clinical and behavioral improvement. During
1 year period of the efficacy and safety of LHRH analog by intranasal and subcutaneous routes in
patients with sexual precocity. So we report this case with a brief review of the literatures. |
| Key Words:
Idiopathic precocious puberty, LHRH analog |
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