| Diurnal Variation in Serum Bilirubin Concentration of Normal Newborn Infant |
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Cheol Am Kim, Jin Geong Jeong, Eui Tak Oh, Hong Ja Gang, Gil Seu Kim |
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Department of Pediatrics, Dae Dong Hospital, Pusan, Korea |
| 정상 신생아에서 혈청 빌리루빈 농도의 하루 변화 |
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김철암, 정진경, 오의탁, 강홍자, 김길서 |
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대동병원 소아과 |
Correspondence:
Gil Seu Kim, Email: 1
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| Abstract |
Purpose
: We investigated whether there are independent intradaily changes in bilirubin levels in
normal neonates.
Methods
: During the period of January 1996 till July 1996, 100 healthy newborn infants were
studied for at least 3 consecutive days. Starting from the third day of life, consistent intradaily
changes of bilirubin concentration were observed. And obstetric history, birth history, weight
change at 3 days were recorded from chart review. A complete blood cell count was obtained
from each subject at the beginning of the study
Results
: The mean bilirubin concentrations at morning were 10.4¡¾1.8mg/dl (3rd day), 11.6¡¾
2.1mg/dl (4th day) and 11.2¡¾2.7mg/dl (5th day). The mean bilirubin concentrations at evening
were 11.1¡¾2.1mg/dl (3rd day), 11.3¡¾2.2mg/dl (4th day) and 10.8¡¾2.8mg/dl (5th day). Interdaily
changes of bilirubin levels were found : morning levels were higher compared with those of the
evening.
Conclusion
: We showed a consistent diurnal rhythm in bilirubin levels, with higher levels in the
morning than in the evening. This diurnal rhythm in serum bilirubin concentration affects
endogenous factors as well as exogenous. Mechanism of diurnal variation was unknown. |
| Key Words:
Neonatal hyperbilirubinemia, Diurnal variation |
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