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Original Article
Neurology
Effectiveness of Helmet therapy for infants with moderate to severe positional plagiocephaly
Jeongho Kim, Jina Kim, Kyu Young Chae
Clin Exp Pediatr. 2024;67(1):46-53.   Published online December 5, 2023
Question: Is helmet therapy effective for positional plagiocephaly? What factors influence helmet therapy efficacy for positional plagiocephaly?
Finding: Helmet therapy is effective for infants with moderate to severe positional plagiocephaly, and its effectiveness is influenced by age at treatment initiation, severity of head asymmetry, and daily duration of helmet wear.
Meaning: Pediatricians should initiate helmet therapy for positional plagiocephaly sooner, ideally before 9 months of age, to maximize treatment efficacy.
Neurodevelopmental outcomes and comorbidities of children with congenital muscular torticollis: evaluation using the National Health Screening Program for Infants and Children database
Og Hyang Kim, Seung Won Lee, Eun Kyo Ha, Ju Hee Kim, Yun Hye Jo, Seongyeong Rhie, Man Yong Han, Kyu Young Chae
Clin Exp Pediatr. 2022;65(6):312-319.   Published online December 9, 2021
Question: What comorbidities are increased in children with congenital muscular torticollis (CMT)? Are there differences in the neurodevelopmental outcomes of children with CMT who received physical therapy versus those who did not?
Finding: The risk of congenital musculoskeletal deformities is increased in CMT. Children who did not receive physical therapy were at greater risk of neurodevelopmental delay.
Meaning: In CMT, musculoskeletal comorbidities should be identified and active early treatment provided.
Allergy
Cohort profile: National Investigation of Birth Cohort in Korea study 2008 (NICKs-2008)
Ju Hee Kim, Jung Eun Lee, So Min Shim, Eun Kyo Ha, Dong Keon Yon, Ok Hyang Kim, Ji Hyeon Baek, Hyun Yong Koh, Kyu Young Chae, Seung Won Lee, Man Yong Han
Clin Exp Pediatr. 2021;64(9):480-488.   Published online January 5, 2021
This national cohort study included all Korean children born in 2008 and 2009 observed over a period of more than 10 years. Our findings demonstrate that it is possible to analyze disease onset prior to hospitalization based on information such as lifestyle, eating habits, and risk factors by integrating National Health Insurance System data with national health screening data.
Depression and marital intimacy level in parents of infants with sleep onset association disorder: a preliminary study on the effect of sleep education
Sihyoung Lee, Seonkyeong Rhie, Kyu Young Chae
Clin Exp Pediatr. 2013;56(5):211-217.   Published online May 28, 2013
Purpose

Sleep onset association disorder (SOAD) is a form of behavioral insomnia observed in children that is caused by inappropriate sleep training. SOAD typically disturbs the sleep of not only infants and children but also their parents. We investigated levels of depression and marital intimacy among parents of infants with typical SOAD, to understand the influence of SOAD on family dynamics,...

Sleep patterns and school performance of Korean adolescents assessed using a Korean version of the pediatric daytime sleepiness scale
Seonkyeong Rhie, Sihyoung Lee, Kyu Young Chae
Clin Exp Pediatr. 2011;54(1):29-35.   Published online January 31, 2011
Purpose

Korean adolescents have severe nighttime sleep deprivation and daytime sleepiness because of their competitive educational environment. However, daytime sleep patterns and sleepiness have never been studied using age-specific methods, such as the pediatric daytime sleepiness scale (PDSS). We surveyed the daytime sleepiness of Korean adolescents using a Korean translation of the PDSS.

Methods

We distributed the 27-item questionnaire, including the PDSS and...

Review Article
Obstructive sleep apnea syndrome in children: Epidemiology, pathophysiology, diagnosis and sequelae
Sun Jung Chang, Kyu Young Chae
Clin Exp Pediatr. 2010;53(10):863-871.   Published online October 31, 2010

The prevalence of pediatric obstructive sleep apnea syndrome (OSAS) is approximately 3% in children. Adenotonsillar hypertrophy is the most common cause of OSAS in children, and obesity, hypotonic neuromuscular diseases, and craniofacial anomalies are other major risk factors. Snoring is the most common presenting complaint in children with OSAS, but the clinical presentation varies according to age. Agitated sleep with...

Original Article
A pilot study of neuroprotection with umbilical cord blood cell transplantation for preterm very low birth weight infants
Kyu Young Chae, Kyu Hyung Lee, So-Hee Eun, Byung Min Choi, Baik-Lin Eun, Hoon-Chul Kang, Myung Jae Chey, Nam Keun Kim, Doyeun Oh
Clin Exp Pediatr. 2007;50(9):882-890.   Published online September 15, 2007
Purpose : Preterm very low birth weight infant have high rate of adverse neurodevelopmental sequale. Recently, there have been lots of reports that human umbilical cord blood transplantation ameliorates functional deficits in animal models as hypoxic ischemic injury. This pilot study was undertaken to determine the clinical efficacy and safety of autologous umbilical cord blood cell transplantation for preventing neurodevelopmental...
Correlation of serum total hydroperoxide levels and diseases of prematurity
Shin-Hye Kim, Hae Young Hur, Kyu Hyoung Lee, Ja Young Moon, Kyu Young Chae
Clin Exp Pediatr. 2007;50(8):746-751.   Published online August 15, 2007
Purpose : Total hydroperoxide (TH), free radical-mediated oxidation product can be used as a measure of free radical injury. The aim of the present study was to see if preterm newborns are at increased risk for oxidative stress compared with term newborns, and to determine whether oxidative stress during postnatal first 1 week is associated with clinical outcomes in preterm...
Review Article
Physiology of sleep
Kyu Young Chae
Clin Exp Pediatr. 2007;50(8):711-717.   Published online August 15, 2007
Sleep is a vital, highly organized process regulated by complex systems of neuronal networks and neurotransmitters. Normal sleep comprises non-rapid eye movement (NREM) and REM periods that alternate through the night. Sleep usually begins in NREM and progresses through deeper NREM stages (2, 3, and 4 stages), but newborns enter REM sleep (active sleep) first before NREM (quiet sleep). A...
Original Article
Clinical Features of Benign Infantile Convulsions with Gastroenteritis
Jung Sun Lee, Hae Oak Kwon, Young Mee Jee, Kyu Young Chae
Clin Exp Pediatr. 2005;48(7):753-759.   Published online July 15, 2005
Purpose : This study was performed to characterize clinical features of benign convulsions with gastroenteritis(CwG) in infants. Methods : We reviewed clinical features of 67 episodes in 64 patients with afebrile seizure accompanied gastroenteritis admitted to Dept. of Pediatrics Bundang CHA hospital from January 2001 to June 2004. Patients with meningitis, encephalitis/encephalopathy or apparent history of epilepsy were excluded. Results : There...
The Levels of Zinc and Neuron-specific Enolase in Febrile Convulsion
Hong Sang Cho, Jun Hun Shin, Ji Yeoung Seo, Cho Ae Lee, Se Hyun Kim, Kyu Young Chae
Clin Exp Pediatr. 2004;47(10):1087-1092.   Published online October 15, 2004
Purpose : To determine the role of zinc in febrile convulsion and to evaluate whether febrile convulsion causes neuronal damage, serum and cerebrospinal fluid(CSF), zinc and CSF neuron-specific enolase(NSE) levels were measured in patients with febrile convulsion, epilepsy and aseptic meningitis. Methods : Three groups were formed as follows : group I : 53 children with febrile convulsion; group II :...
Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Risk of Down Syndrome
Kyu Young Chae, Jin Hee Han, Ji Yeong Seo, Min Jung Cho, Sehyun Kim, Nam Keun Kim
Clin Exp Pediatr. 2004;47(10):1053-1057.   Published online October 15, 2004
Purpose : The C677T polymorphism of the methylenetetrahydrofolate reductase(MTHFR) has been suggested as a risk factor of maternal meiotic nondisjunction for Down syndrome. Recently, a second genetic polymorphism in MTHFR at position 1298 was reported. However, a positive association between the A1298C MTHFR polymorphism and Down syndrome has not been reported. Therefore, this study was undertaken to determine which polymorphism...
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