Clinical and Experimental Pediatrics

Review Article

Infection

Etiological and pathophysiological enigmas of severe coronavirus disease 2019, multisystem inflammatory syndrome in children, and Kawasaki disease

Jung-Woo Rhim, Jin-Han Kang, Kyung-Yil Lee

Clin Exp Pediatr. 2022;65(4):153-166. Published online November 23, 2021

Web of Science 13 Crossref 13

· Severe cases of coronavirus disease, Kawasaki disease (KD), and multisystem inflammatory syndrome in children (MIS-C) share similar findings: a protracted clinical course, multiorgan involvement, and similar activated biomarkers.
· Here we propose etiological agents in KD and MIS-C as species in the microbiota and introduce a common pathogenesis through the protein-homeostasis-system hypothesis.
· Early proper dose of corticosteroids and/or intravenous immunoglobulin may help to reduce morbidity and mortality in these diseases.

DOI: https://doi.org/10.3345/cep.2021.01270

Original Article

Infection

Febrile urinary tract infection in children: changes in epidemiology, etiology, and antibiotic resistance patterns over a decade

Woosuck Suh, Bi Na Kim, Hyun Mi Kang, Eun Ae Yang, Jung-Woo Rhim, Kyung-Yil Lee

Clin Exp Pediatr. 2021;64(6):293-300. Published online October 14, 2020

Web of Science 5 Crossref 6

Question: How has the antibiotic susceptibility of urinary pathogens changed and what does it imply?
Finding: A yearly increase in multidrug-resistant and extended-spectrum β-lactamase (ESBL)–producing pathogens was observed. A higher recurrence rate was observed in cases of febrile urinary tract infection caused by ESBL producers in patients with underlying vesicoureteral reflux (VUR).
Meaning: The initial empirical antibiotic should reflect the changing susceptibility patterns and underlying VUR status.

DOI: https://doi.org/10.3345/cep.2020.00773

Review Article

Immunology

Immunopathogenesis of COVID-19 and early immunomodulators

Kyung-Yil Lee, Jung-Woo Rhim, Jin-Han Kang

Clin Exp Pediatr. 2020;63(7):239-250. Published online June 18, 2020

Crossref 32

The novel coronavirus disease 2019 (COVID-19) is spreading globally. Although its etiologic agent is discovered as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there are many unsolved issues in COVID-19 and other infectious diseases. The causes of different clinical phenotypes and incubation periods among individuals, species specificity, and cytokine storm with lymphopenia as well as the mechanism of damage to organ...

DOI: https://doi.org/10.3345/cep.2020.00759

Perspective

Pulmonology

Early preemptive immunomodulators (corticosteroids) for severe pneumonia patients infected with SARS-CoV-2

Kyung-Yil Lee, Jung-Woo Rhim, Jin-Han Kang

Clin Exp Pediatr. 2020;63(4):117-118. Published online April 8, 2020

Web of Science 14 Crossref 14

DOI: https://doi.org/10.3345/cep.2020.00290

Original Article

Cardiology

Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment

Yu-Mi Seo, Hyun-Mi Kang, Sung-Churl Lee, Jae-Won Yu, Hong-Ryang Kil, Jung-Woo Rhim, Ji-Whan Han, Kyung-Yil Lee

Clin Exp Pediatr. 2018;61(5):160-166. Published online May 28, 2018

Crossref 22

Purpose

This study aimed to analyse laboratory values according to fever duration, and evaluate the relationship across these values during the acute phase of Kawasaki disease (KD) to aid in the early diagnosis for early-presenting KD and incomplete KD patients.

Methods

Clinical and laboratory data of patients with KD (n=615) were evaluated according to duration of fever at presentation, and were compared between...

DOI: https://doi.org/10.3345/kjp.2018.61.5.160

Epidemiological comparison of three Mycoplasma pneumoniae pneumonia epidemics in a single hospital over 10 years

Eun-Kyung Kim, You-Sook Youn, Jung-Woo Rhim, Myung-Seok Shin, Jin-Han Kang, Kyung-Yil Lee

Clin Exp Pediatr. 2015;58(5):172-177. Published online May 22, 2015

Crossref 55

Purpose

Mycoplasma pneumoniae (MP) pneumonia epidemics have occurred in 3- to 4-year cycles in Korea. We evaluated the epidemiologic characteristics of MP pneumonia in Daejeon, Korea, from 2003 to 2012.

Methods

We retrospectively analyzed 779 medical records of children (0-15 years of old) with MP pneumonia admitted to our institution and compared the data from 3 recent epidemics.

Results

In 779 patients, the mean age...

DOI: https://doi.org/10.3345/kjp.2015.58.5.172

Outbreaks of mumps: an observational study over two decades in a single hospital in Korea

Ji-Ung Ryu, Eun-Kyung Kim, You-Sook Youn, Jung-Woo Rhim, Kyung-Yil Lee

Clin Exp Pediatr. 2014;57(9):396-402. Published online September 30, 2014

Crossref 8

Purpose

The introduction of the mumps vaccine has dramatically reduced the number of mumps cases, but outbreaks have recently occurred among highly vaccinated populations in developed countries. Epidemiological and clinical characteristics of patients with mumps admitted between 1989 and 2012 in a single hospital in Korea are described in the present study.

Methods

We retrospectively evaluated inpatients with mumps between 1989 and 2012...

DOI: https://doi.org/10.3345/kjp.2014.57.9.396

Cited By 22	Retinopathy of prematurity: a review of epidemiology and current treatment strategies
Cited By 20	Genetic factors in precocious puberty
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Cited By 13	Etiological and pathophysiological enigmas of severe coronavirus disease 2019, multisystem inflammatory syndrome in children, and Kawasaki disease

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