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A Case of Trensient Myeloproliferative Disorder with Down Syndrome.

Journal of the Korean Pediatric Society 1983;26(10):1024-1028.
Published online October 31, 1983.
A Case of Trensient Myeloproliferative Disorder with Down Syndrome.
Dong Gyoon Kim, Jae Ho Lee, Jung Il Noh, Hyo Seop Ahn, Chang Yee Hong
Department of Pediatrics,College of Medicine, Seoul National University
일과성 골수증식장애를 나타낸 Down 증후군의 1 례
김동균, 이재호, 노정일, 안효섭, 홍창의
서울대학교 의과대학 소아과학교실
Transient myeloproliferative disorder has been reported in infants with Down syndrome. Infants with Down syndrome and this transient myeloproliferative disorder often present with signs and symptoms that are clinically and hematologically indistinguishable from congenital acute myelogenous leukemia. In contrast to congenital AML, complete clinical and hematological recovery occurs within weeks to months of diagnosis without any specific anti- leukemic treatment. A case of transient myeloproliferative disorder with Down syndrome in a 17 days old male is experienced and is reported with literature review. He showed jaundice, hepatosplen- omegaly and petechiae. Peripheral blood smear and bone marrow examination revealed a picture of leukemia. But clinical and hematological improvement occurred after 3 months without any specific anti-leukemic treatment.
Key Words: Transient myeloproliferative disorder, Down syndrome.

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