| Change of NK Cell and LAK Cell Activity of Cancer Patients in Postchemotherapy Period. |
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Chong Sung Chung, Kyuchul Choeh, Yong Mook Choi |
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Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea |
| 소아기 악성종양 환자의 면역기능의 변화
- Natural-Killer세포 활성도와 Lymphokine-Activated-Killer 세포 활성도를 중심으로 - |
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정종성, 최규철, 최용묵 |
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경희대학교 의과대학 소아과학교실 |
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Received: 2 November 1988 • Accepted: 16 December 1988 |
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| Abstract |
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This study was undertaken to evaluate the Natueral-Killer (NK) cell and Lymphokine-Activated-Killer (LAK) cell
activity of cancer patients for the prupose of understanding of spontaneous cell-mediated cytotoxicity (SCMC) in
cancer patients and understanding of interrelationship between NK cell and LAK cell.
Total 9 cases of malignant tumor (7 cases: Acute leukemia, 2 cases: malignant lymphoma) below 15 years of age,
who were on remission stage and had completed antineoplastic combination chemotherapy, were evaluated at constant interval from the end of chemotherapy.
The results were as follows;
1) The NK cell activity of cancer patients was lower than that of control immediately after the end of antineoplas-
tic combination chemotherapy, the former was 32.13± 15.28% and the latter was 45.89±10.22%. (P<0.05)
2) The NK cell activity of cancer patients increased significantly after 12 months of period form the end of
chemotherapy. (P<0.05)
3) The LAK cell activity of cancer patients were not influenced by tumor immunity or immunosuppressive agents,
and so no significant change at any time. |
| Key Words:
NK cell activity, LAK cell activity, Cancer |
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