Journal of the Korean Pediatric Society 1991;34(3):317-322.
Published online March 31, 1991.
Changes of immune indices in children with recurrent gross hematuria (IgA nephropathy and non-IgA nephropathy) and Henoch-Schonlein purpura nephritis.
Seong Mi Kim1, Myung Chul Hyun1, Cheol Woo Ko1, Ja Hoon Koo1, Doo Hong Ahn1, Jung Sik Kwack2
1Department of Pediatrics, School of Medicine, Kyungpook National University, Taegu, Korea
2Department of Pathology, School of Medicine, Kyungpook National University, Taegu, Korea
반복성 혈뇨(lgA 신병증 및 non-IgA 신병증)와 Henoch-schonlein 신염의 면역지표의 변동에 관하여
김승미1, 현명철1, 고철우1, 구자훈1, 안두홍1, 곽정식2
1경북대학교 의과대학 소아과학교실
2경북대학교 의과대학 병리학교실
Received: 23 January 1991   • Accepted: 20 February 1991
Abstract
A Prospective study was conducted to see the changes of immune system in recurrent gross hematuria (IgA nephropathy and non-IgA nephropathy) and HSP nephritis in children. Study patients consisted of 60 children with recurrent gross hematuria and Henoch-schdnlein purpura nephritis (8 IgA nephropathy, 24 non-IgA nephropathy and 28 HSP nephritis). The cellular immune indices (total T, T4, T8 cells and T4/T8 ratio) and humoral immune indices (IgG, A, M and E) were measured during the hematuric and non-hematuric period. Following results were obtained. The proportion of T4 cells of peripheral blood during the hematuric period of patients with IgA nephropathy rose to 35.4±14.9% from the non-hematuric value of 20.0士9.1%. The T4/T8 ratio during hematuric period of patients with IgA nephropathy rose to 1.51±0.77 from non-hematuric valus of 0.73±0.33. The values of serum IgA and IgE during hematuric period of patients with IgA nephropathy rose to 237 ±106 mg/dl, 231 ±226 IU/dl from non-hematuric values of 140 ±10, 28±23, respectively. These changes of cellular and humoral immune indices showed statistically significant differences(p < 0.05). However, these changes were not found in patients with non-IgA nephropathy nor HSP nephritis. In conclusion, it can be said that the immune mechanism involved in IgA nephropathy is different from that of HSP nephritis.
Key Words: IgA nephropathy, Henoch-schonlein purpura nephritis, Immune index




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