Korean Journal of Pediatrics 2010;53(4):554-559.
Published online April 15, 2010.
A study on the therapeutic effects of Topiramate according to the types of migraine
Jun Hwa Lee, Kyung Lae Cho
Department of Pediatrics, Masan Samsung Hospital, Sungkyunkwan University School of Medicine
편두통의 형태에 따른 Topiramate의 치료효과 -무 전조 편두통, 전조 편두통, 그리고 개연적 편두통에 대한 topiramate의 치료 효과 및 치료이후의 임상경과-
이준화, 조경래
성균관대학교 의과대학 마산삼성병원 소아과학교실
Correspondence: 
Kyung Lae Cho, Email: pedikyung@yahoo.co.kr
Abstract
Purpose
: The purpose of this study was to evaluate whether the therapeutic effects of topiramate differ according to the types of migraine.
Methods
: We recruited 38 children and adolescents with migraine who had been treated with topiramate. The effect of topiramate was evaluated on the basis of the change in the frequency of migraine attacks after treatment.
Results
: Among patients having migraine with aura, 85.7% showed complete recovery, 1 (7.1%) showed partial recovery, and 1 did not show any recovery. Among patients having migraine without aura, 47.1% showed complete recovery, 29.4 % showed partial recovery, and 23.5% showed no recovery. Among patients suspected with migraine, 1 (20%) showed complete recovery, 1 (20%) showed partial recovery, and 3 (60%) showed no recovery.
Conclusion
: Our results indicated that topiramate exhibited excellent therapeutic effects for migraine accompanied with aura, and it was effective in migraine without aura. However, the effect of topiramate in patients suspected with migraine was uncertain.
Key Words: Migraine, Aura, Topiramate, Child


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