| Comparison of The Efficacy of the Fiberoptic Phototherapy and Conventional Phototherapy for Neonatal Hyperbilirubinemia |
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Hye Jung Min, Gwi Sook Kim, Soo Kyung Lee, Il Kyung Kim, Ho Sung, Chang Hee Choi |
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Department of Pediatrics, Seoul Adventist Hospital, Seoul, Korea |
| 신생아 황달에 있어서 고식적 광선 치료와 광섬유 광선 치료의 효과에 대한 비교 |
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민혜정, 김귀숙, 이수경, 김일경, 성호, 최창희 |
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서울 위생병원 소아과 |
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| Abstract |
Purpose
: We performed this study in order to compare the feasibility and efficacy of the
fiberoptic phototherapy with conventional phototherapy and double phototherapy with single
phototherapy for the treatment of neonatal hyperbilirubinemia while watching for any possible
side effects of the system.
Methods
: During the period of February 1994 till June 1995, randomized controlled study
was performed. 130 healthy term infants with non-hemolytic hyperbilirubinemia were enrolled,
45 patients received fiberoptic phototherapy, 40 patients received conventional phototherapy and
45 patients received double phototherapy. Criteria for inclusion in the study were 1) after 37
weeks of gestation 2) negative result of a direct coombs test 3) normal hemoglobin and
hematocrit 4) no Rh or ABO incompatibility 5) plasma total bilirubin concentration exceed
10mg/dl during the first 3 days of life.
Results
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1) The mean total bilirubin decline level after 24 hours was 0.03¡¾2.03mg/dl and the mean
indirect bilirubin decline level after 24 hours was 0.12¡¾1.35mg/dl in conventional phototherapy
group(p<0.01), but in fiberoptic phototherapy group, the mean total bilirubin level was increased
1.26¡¾1.68mg/dl and the mean indirect bilirubin level was increased 1.10¡¾1.70mg/dl after 24
hours (p>0.01).
2) The mean total bilirubin decline level after 48 hours was 1.25¡¾2.71mg/dl and the mean
indirect bilirubin decline level was 1.17¡¾1.52mg/dl in conventional phototherapy group (p<0.01).
But in fiberoptic phototherapy group, the mean total bilirubin level was increased 0.97¡¾2.81
mg/dl and the mean indirect bilirubin level was increased 0.29¡¾1.80mg/dl after 48 hours (p>
.01).
3) The mean decline levels of 24 hours-total and indirect bilirubin were 0.01¡¾1.23mg/dl and
0.09¡¾1.13mg/dl, and the mean decline levels of 48hours-total and indirect bilirubin were
0.92¡¾1.85mg/dl and 0.99¡¾1.08mg/dl (p<0.01), respectively, in double phototherapy group. But
there were no statistically significant differences compared with the mean bilirubin decline levels
in single phototheray group.
4) There were no significant differences in side effects such as decreased urine volume
(p>0.01) or diarrhea(p>0.01) among three groups.
Conclusion
: We conclude that fiberoptic phototherapy has less efficacy comparable to that of
conventional phototherapy and double phototherapy has no significant differences in effectiveness
compared with conventional phototherapy. So we hope further studies on the effects of the
fiberoptic phototherapy in preterm infants and in after 48 hours will be done. |
| Key Words:
Bilirubin, Newborn, Non-hemolytic hyperbilirubinemia, Conventional phototherapy, Fiberoptic phototherapy |
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