- Editorial
- Neonatology (Perinatology)
- Eosinophil count and neutrophil-to-lymphocyte count ratio as biomarkers for predicting early-onset neonatal sepsis
- Jang Hoon Lee
- Clin Exp Pediatr. 2019;62(12):438-439. Published online July 9, 2019
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- Clinical note
- Neonatology (Perinatology)
- Gray-brown skin discoloration following phototherapy for hyperbilirubinemia due to anti-E alloimmunization
- Da Jeong Lee, Woo Sun Song, Seung Yeon Kim
- Clin Exp Pediatr. 2019;62(11):428-430. Published online September 18, 2019
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- Editorial
- Neonatology (Perinatology)
- Controversy in the diagnosis and treatment of hemodynamically significant patent ductus arteriosus in preterm infants
- Se In Sung
- Clin Exp Pediatr. 2019;62(11):410-411. Published online June 21, 2019
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- Original Article
- Neonatology (Perinatology)
- Clinical impact of admission hypothermia in very low birth weight infants: results from Korean Neonatal Network
- Na Hyun Lee, Soo Kyung Nam, Juyoung Lee, Yong Hoon Jun
- Clin Exp Pediatr. 2019;62(10):386-394. Published online May 22, 2019
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Background: Preterm infants have difficulty maintaining body temperature after birth. However, clinical guidelines advocate that neonatal body temperature should be maintained at 36.5°C–37.5°C.
Purpose: We aimed to investigate the incidence of admission hypothermia in very low birth weight (VLBW) infants and to determine the association of admission temperature with in-hospital mortality and morbidities. Methods: A cohort study using prospectively collected data involving...
- Editorial
- Neonatology (Perinatology)
- Central line-associated bloodstream infections in the neonatal intensive care unit
- Woo Ryoung Lee
- Clin Exp Pediatr. 2019;62(10):382-383. Published online July 17, 2019
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- Strategies to improve outcomes of bronchopulmonary dysplasia
- Young Hwa Jung, Chang Won Choi, Beyong Il Kim
- Clin Exp Pediatr. 2019;62(10):380-381. Published online September 11, 2019
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- Review Article
- Neonatology (Perinatology)
- Bronchopulmonary dysplasia: how can we improve its outcomes?
- Tae-Jung Sung
- Clin Exp Pediatr. 2019;62(10):367-373. Published online May 17, 2019
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Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants with multiple factors affected from prenatal to postnatal periods. Despite significant advances in neonatal care over almost 50 years, BPD rates have not decreased; in fact, they may have even increased. Since more preterm infants, even at periviable gestational age, survive today, different stages of lung development affect the...
- Original Article
- Neonatology (Perinatology)
- The relation between serum levels of epidermal growth factor and necrotizing enterocolitis in preterm neonates
- Heba Mostafa Ahmed, Nsreen Mostafa Kamel
- Clin Exp Pediatr. 2019;62(8):307-311. Published online March 15, 2019
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Purpose: Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport. The aim of this study was to assess the role of epidermal growth factor in the...
- Review Article
- Neonatology (Perinatology)
- Practice for preterm patent ductus arteriosus; focusing on the hemodynamic significance and the impact on the neonatal outcomes
- Jin A Lee
- Clin Exp Pediatr. 2019;62(7):245-251. Published online April 8, 2019
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Hemodynamically significant preterm patent ductus arteriosus (PDA) affects mortality; comorbidities such as necrotizing enterocolitis, intraventricular hemorrhage, and bronchopulmonary dysplasia; and adverse long-term neurodevelopmental outcomes in preterm infants, particularly in very low birth weight infants. However, recent studies have indicated that there is no consensus on the causal relationship between PDA and neonatal outcomes, the benefit of PDA treatment, the factors...
- Original Article
- Neonatology (Perinatology)
- Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis
- Rocky Wilar
- Clin Exp Pediatr. 2019;62(6):217-223. Published online October 8, 2018
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Purpose: To determine the diagnostic value of eosinopenia and the neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of early onset neonatal sepsis (EONS). Methods: This cross-sectional study was conducted in the Neonatology Ward of R.D. Kandou General Hospital Manado between July and October 2017. Samples were obtained from all neonates meeting the inclusion criteria for EONS. Data were encoded using logistic regression...
- Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants
- Ian Kim, Sung Shin Kim, Jee In Song, Seock Hwa Yoon, Ga Young Park, Yong-Wha Lee
- Clin Exp Pediatr. 2019;62(5):166-172. Published online October 24, 2018
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Purpose: This study aimed to evaluate vitamin D status at birth in very-low-birth-weight infants (VLBWIs: <1,500 g) and to determine the association between vitamin D level and respiratory morbidity. Methods: A retrospective study was conducted at Soonchunhyang University Bucheon Hospital between November 2013 and November 2017. We collected blood samples and data on respiratory morbidity from 230 VLBWIs on the first...
- Editorial
- Neonatology (Perinatology)
- Association of vitamin D status at birth and respiratory outcomes in preterm infants
- Sook-Hyun Park
- Clin Exp Pediatr. 2019;62(5):162-163. Published online April 8, 2019
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- Review Article
- Neonatology (Perinatology)
- Surfactant preparations for preterm infants with respiratory distress syndrome: past, present, and future
- Ga Won Jeon
- Clin Exp Pediatr. 2019;62(5):155-161. Published online February 8, 2019
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Following the first successful trial of surfactant replacement therapy for preterm infants with respiratory distress syndrome (RDS) by Fujiwara in 1980, several animal-derived natural surfactants and synthetic surfactants have been developed. Synthetic surfactants were designed to overcome limitations of natural surfactants such as cost, immune reactions, and infections elicited by animal proteins contained in natural surfactants. However, first-generation synthetic surfactants...
- Original Article
- Neonatology (Perinatology)
- Iron status in small for gestational age and appropriate for gestational age infants at birth
- Hyeon A Kim, Sook-Hyun Park, Eun Joo Lee
- Clin Exp Pediatr. 2019;62(3):102-107. Published online October 24, 2018
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Purpose: This study compared the iron statuses of small for gestational age (SGA) and appropriate for gestational age (AGA) infants at birth. Methods: The clinical data of 904 newborn infants admitted to the neonatal intensive care unit were reviewed. Blood samples were drawn from the infants within 24 hours after birth. Serum ferritin level was used as a marker of total...
- Dorsal midline cutaneous stigmata associated with occult spinal dysraphism in pediatric patients
- Hyun Jung Sung, Hyun-Seung Lee
- Clin Exp Pediatr. 2019;62(2):68-74. Published online October 1, 2018
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Purpose: To investigate the prevalence of occult spinal dysraphism (OSD) and subsequent neurosurgery in pediatric patients with isolated or combined dorsal midline cutaneous stigmata with or without other congenital malformations. Methods: We carried out a retrospective review of patients who underwent sonography or magnetic resonance imaging (MRI) for OSD because of suspicion of dorsal midline cutaneous stigmata (presumed to be a...
- Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit
- Se Jin Kim, Ga Eun Kim, Jae Hyun Park, Sang Lak Lee, Chun Soo Kim
- Clin Exp Pediatr. 2019;62(1):36-41. Published online September 27, 2018
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Purpose: In this study, we investigated the clinical features and prognostic factors of early-onset sepsis (EOS) in neonatal intensive care unit (NICU) patients. Methods: A retrospective analysis was conducted on medical records from January 2010 to June 2017 (7.5 years) of a university hospital NICU. Results: There were 45 cases of EOS (1.2%) in 3,862 infants. The most common pathogen responsible for...
- Evaluation of prolonged pain in preterm infants with pneumothorax using heart rate variability analysis and EDIN (Échelle Douleur Inconfort Nouveau-Né, neonatal pain and discomfort scale) scores
- Mehmet Buyuktiryaki, Nurdan Uras, Nilufer Okur, Mehmet Yekta Oncel, Gulsum Kadioglu Simsek, Sehribanu Ozluer Isik, Serife Suna Oguz
- Clin Exp Pediatr. 2018;61(10):322-326. Published online September 16, 2018
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Purpose: The EDIN scale (Échelle Douleur Inconfort Nouveau-Né, neonatal pain and discomfort scale) and heart rate variability has been used for the evaluation of prolonged pain. The aim of our study was to assess the value of the newborn infant parasympathetic evaluation (NIPE) index and EDIN scale for the evaluation of prolonged pain in preterm infants with chest tube placement...
- Transient intubation for surfactant administration in the treatment of respiratory distress syndrome in extremely premature infants
- Ji Won Koh, Jong-Wan Kim, Young Pyo Chang
- Clin Exp Pediatr. 2018;61(10):315-321. Published online September 16, 2018
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Purpose: To investigate the effectiveness of transient intubation for surfactant administration and extubated to nasal continuous positive pressure (INSURE) for treatment of respiratory distress syndrome (RDS) and to identify the factors associated with INSURE failure in extremely premature infants. Methods: Eighty-four infants with gestational age less than 28 weeks treated with surfactant administration for RDS for 8 years were included. Perinatal...
- Oral findings and its association with prenatal and perinatal factors in newborns
- Brenda Perez-Aguirre, Uriel Soto-Barreras, Juan Pablo Loyola-Rodriguez, Juan Francisco Reyes-Macias, Miguel Angel Santos-Diaz, Alejandra Loyola-Leyva, Obed Garcia-Cortes
- Clin Exp Pediatr. 2018;61(9):279-284. Published online September 15, 2018
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Purpose: This study aimed to determine the frequency of abnormalities in the newborn oral cavity and to evaluate the association with prenatal and perinatal factors. Methods: This cross-sectional study evaluated 2,216 newborns. Oral findings were assessed in the first 24 hours of life using visual examination. Sex, weight, length, gestational age, and medical disorders at birth were recorded. Maternal demographic and...
- Review Article
- Neonatology (Perinatology)
- Transfusion practice in neonates
- Do-Hyun Kim
- Clin Exp Pediatr. 2018;61(9):265-270. Published online September 6, 2018
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Neonates, especially extremely low birth weight infants, are among the groups of patients undergoing transfusion frequently. Since they are exposed to higher specific transfusion risks compared to the patients of other age groups, there are many special aspects that must be considered for transfusion therapy in neonates. The transfusion risks in neonates include adverse outcomes specific for preterm infants as...
- Original Article
- Neonatology (Perinatology)
- Patterns of ischemic injury on brain images in neonatal group B Streptococcal meningitis
- Seo Yeol Choi, Jong-Wan Kim, Ji Won Ko, Young Seok Lee, Young Pyo Chang
- Clin Exp Pediatr. 2018;61(8):245-252. Published online August 15, 2018
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Purpose: This study investigated patterns of ischemic injury observed in brain images from patients with neonatal group B Streptococcal (GBS) meningitis. Methods: Clinical findings and brain images from eight term or near-term newborn infants with GBS meningitis were reviewed. Results: GBS meningitis was confirmed in all 8 infants via cerebrospinal fluid (CSF) analysis, and patients tested positive for GBS in both blood and CSF cultures....
- The impact of a quality improvement effort in reducing admission hypothermia in preterm infants following delivery
- Han Saem Choi, Soon Min Lee, Hoseon Eun, Minsoo Park, Kook-In Park, Ran Namgung
- Clin Exp Pediatr. 2018;61(8):239-244. Published online August 15, 2018
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Purpose: Hypothermia at admission is associated with increased mortality and morbidity in preterm infants. We performed a quality improvement (QI) effort to determine the impact of a decrease in admission hypothermia in preterm infants. Methods: The study enrolled very low birth weight (VLBW) infants born at Gangnam Severance Hospital between January 2013 and December 2016. This multidisciplinary QI effort included the...
- Diagnostic and prognostic value of proadrenomedullin in neonatal sepsis
- Sameh Samir Fahmey, Heba Mostafa, Noha Abd Elhafeez, Heba Hussain
- Clin Exp Pediatr. 2018;61(5):156-159. Published online May 28, 2018
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Purpose Sepsis is a major cause of neonatal morbidity and mortality. Early diagnosis is a major problem because of the lack of specific clinical signs. Therefore, a reliable diagnostic marker is needed to guide the use of antimicrobial agents. The objective of our study was to assess the value of proadrenomedullin (pro-ADM) in establishing the diagnosis and evaluating the prognosis of...
- TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus) screening of small for gestational age and intrauterine growth restricted neonates: efficacy study in a single institute in Korea
- Mi Hae Chung, Chan Ok Shin, Juyoung Lee
- Clin Exp Pediatr. 2018;61(4):114-120. Published online April 23, 2018
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Purpose Routine screening for toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (TORCH) in intrauterine growth restriction (IUGR) and small for gestational age (SGA) neonates has become a common practice. However, the incidence of TORCH varies across countries, and the cost of TORCH testing may be disadvantageous compared to disease-specific screening. To evaluate the efficacy of TORCH screening, the medical charts...
- Augmentation of respiratory muscle activities in preterm infants with feeding desaturation
- Dong Rak Kwon, Gi Young Park, Ji Eun Jeong, Woo Taek Kim, Eun Joo Lee
- Clin Exp Pediatr. 2018;61(3):78-83. Published online March 19, 2018
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Purpose Frequent desaturation due to immature incoordination of suck-swallow-breathing in preterm infants can influence multiple organs such as the heart, lungs, and brain, which can then affect growth and development. Most notably in preterm infants, feeding desaturation may even affect pulmonary function during gavage feeding. Because respiratory muscle activities may reflect the work required during respiration, we evaluated the differences in...
- Comparison of postnatal catch-up growth according to definitions of small for gestational age infants
- Jisun Huh, Ji Yoon Kwon, Hye Ryun Kim, Eun Hee Lee, Young-Jun Rhie, Byung Min Choi, Kee-Hyoung Lee
- Clin Exp Pediatr. 2018;61(3):71-77. Published online March 19, 2018
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Purpose Small for gestational age (SGA) is confusingly defined as birth weight (BW) either below 3rd percentile or 10th percentile for infants. This study aimed to compare postnatal catch-up growth between SGA groups according to different definitions.
Methods Data of 129 infants born with BW below the 10th percentile and admitted to Korea University Anam Hospital and Ansan Hospital were retrospectively reviewed. Height...
- Letter to the Editor
- Neonatology (Perinatology)
- B-type natriuretic peptide may have a role in the management of patent ductus arteriosus
- Jang Hoon Lee
- Clin Exp Pediatr. 2018;61(2):68-69. Published online February 28, 2018
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- Case Report
- Neonatology (Perinatology)
- Case of mucinous adenocarcinoma of the lung associated with congenital pulmonary airway malformation in a neonate
- Juneyoug Koh, Euiseok Jung, Se Jin Jang, Dong Kwan Kim, Byong Sop Lee, Ki-Soo Kim, Ellen Ai-Rhan Kim
- Clin Exp Pediatr. 2018;61(1):30-34. Published online January 22, 2018
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Congenital pulmonary airway malformation (CPAM), previously known as congenital cystic adenomatoid malformation, is a rare developmental lung abnormality associated with rhabdomyosarcoma, pleuropulmonary blastoma, and mucinous adenocarcinoma of the lung. We report an unusual case of a 10-day-old male newborn with a left lower lobe pulmonary cyst who underwent lobectomy, which revealed type II CPAM complicated by multifocal mucinous adenocarcinoma. KRAS...
- Original Article
- Neonatology (Perinatology)
- Does anaesthesia in mothers during delivery affect bilirubin levels in their neonates?
- Zeinab A El-Kabbany, Nadin N Toaima, Tamer N Toaima, Mona Y Gamal EL-Din
- Clin Exp Pediatr. 2017;60(12):385-389. Published online December 22, 2017
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Purpose This study aimed to assess whether different anesthetic techniques and oxytocin use applied during delivery affect transcutaneous bilirubin levels during the first 24 hours in neonates.
Methods A total of 1,044 neonates delivered by either caesarian section (C/S) or normal vaginal delivery (NVD) were included in the study. They were classified into 5 groups as follows: group 1: born by C/S using...
- Hearing loss screening tool (COBRA score) for newborns in primary care setting
- Watcharapol Poonual, Niramon Navacharoen, Jaran Kangsanarak, Sirianong Namwongprom, Surasak Saokaew
- Clin Exp Pediatr. 2017;60(11):353-358. Published online November 27, 2017
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Purpose To develop and evaluate a simple screening tool to assess hearing loss in newborns. A derived score was compared with the standard clinical practice tool.
Methods This cohort study was designed to screen the hearing of newborns using transiently evoked otoacoustic emission and auditory brain stem response, and to determine the risk factors associated with hearing loss of newborns in 3 tertiary...
