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Review Article
Hematology
Genetic classification and confirmation of inherited platelet disorders: current status in Korea
Ye Jee Shim
Clin Exp Pediatr. 2020;63(3):79-87.   Published online February 6, 2020
Inherited platelet disorders (IPDs), which manifest as primary hemostasis defects, often underlie abnormal bleeding and a family history of thrombocytopenia, bone marrow failure, hematologic malignancies, undefined mucocutaneous bleeding disorder, or congenital bony defects. Wide heterogeneity in IPD types with regard to the presence or absence of thrombocytopenia, platelet dysfunction, bone marrow failure, and dysmegakaryopoiesis is observed in patients. The individual...
Letter to the Editor
Neonatology (Perinatology)
Risk factors for BiPAP failure as an initial management approach in moderate to late preterm infants with respiratory distress
Heekwon Son, Eui Kyung Choi, Kyu Hee Park, Jeong Hee Shin, Byung Min Choi
Clin Exp Pediatr. 2020;63(2):63-65.   Published online February 15, 2020
Question: Which factors can predict BiPAP failure as the initial management approach for moderate to late preterm infants with respiratory distress?
Finding: RDS aggravation and increased oxygen and frequency requirements during BiPAP support were associated with BiPAP failure.
Meaning: Early changes to invasive ventilator care should be considered for moderate to late preterm infants showing RDS aggravation and increased oxygen and frequency requirements during BiPAP support.
Original Article
Neonatology (Perinatology)
Effect of red blood cell transfusion on short-term outcomes in very low birth weight infants
Eui Young Lee, Sung Shin Kim, Ga Young Park, Sun Hyang Lee
Clin Exp Pediatr. 2020;63(2):56-62.   Published online February 6, 2020
Question: Does RBC transfusion affect the short-term outcomes of VLBW infants?
Finding: The results showed that RBC transfusion was significantly related to the incidence of BPD (OR, 5.42; P<0.001) and NEC (OR, 3.40; P=0.009).
Meaning: Careful consideration of the patient’s clinical condition and appropriate guidelines is required before administering RBC transfusions.
Gastroenterology
Thyroid disturbances in children treated with combined pegylated interferon-alpha and ribavirin for chronic hepatitis C
Yasser K. Rashed, Fatma A. Khalaf, Sobhy E. Kotb
Clin Exp Pediatr. 2020;63(2):52-55.   Published online September 27, 2019
Background: Immunomodulatory properties of interferon (IFN) have been documented. It may induce autoimmune diseases such as autoimmune thyroiditis with hypo- or hyperthyroidism. In addition, it may impair thyroid hormone synthesis through affecting iodide organification in thyroid gland.
Purpose: The aim of this study was to describe thyroid function tests disturbances in children with chronic hepatitis C (CHC) receiving pegylated interferon-alpha (PEG...
Neonatology (Perinatology)
Placental histopathology in late preterm infants: clinical implications
Kristina Ericksen, Joshua Fogel, Rita P. Verma
Clin Exp Pediatr. 2020;63(2):48-51.   Published online August 19, 2019
Question: Placental histopathology and its clinical implications in late preterm infants.
Finding: Placental vascular anomalies are more, and placental inflammation less common in late preterm infants compared to term. Higher maternal age, magnesium sulfate therapy and hypertension are clinical risk factors associated with late preterm delivery.
Meaning: Prevention and aggressive management of hypertension, and conception before 30 years of age might be effective in preventing late preterm births.
Editorial
Gastroenterology
Strategies for treating and managing chronic hepatitis C in children in the direct-acting antiviral era
Suk-Jin Hong, Byung-Ho Choe
Clin Exp Pediatr. 2020;63(2):46-47.   Published online February 6, 2020
Pulmonology
Are alternative antibiotics needed for antibiotic-nonresponsive Mycoplasma pneumoniae pneumonia?
Eun-Ae Yang, Kyung-Yil Lee
Clin Exp Pediatr. 2020;63(2):44-45.   Published online February 15, 2020
Systematic review and meta-analysis
Genetics and Metabolism
Global prevalence of classic phenylketonuria based on Neonatal Screening Program Data: systematic review and meta-analysis
Hamid Reza Shoraka, Ali Akbar Haghdoost, Mohammad Reza Baneshi, Zohre Bagherinezhad, Farzaneh Zolala
Clin Exp Pediatr. 2020;63(2):34-43.   Published online February 6, 2020
Question: What is the global prevalence of classic phenylketonuria based on Neonatal Screening Program Data?
Finding: The overall worldwide prevalence of the disease is 6.002 per 100,000 neonates. The highest prevalence (38.13) was reported in Turkey, while the lowest (0.3) in Thailand.
Meaning: This difference in the prevalence may be due to differences in the number of consanguineous marriages among the different regions, phenylalanine cutoff points, and sample sizes.
Perspective
General Pediatrics
Integrative care for children with medical complexity
Jung Lee, Min Sun Kim, Hee Young Shin
Clin Exp Pediatr. 2020;63(2):32-33.   Published online November 14, 2019
Clinical Note
Allergy
Complement 4 levels of a 4-year-old girl with angioedema
Soyoung Shin, Yoon Tae Lee, Kyung Yil Lee, Joonhong Park, Jae Ho Lee, Eun Ae Yang
Clin Exp Pediatr. 2020;63(1):30-31.   Published online November 8, 2019
Original Article
Neonatology (Perinatology)
Effectiveness of various nonpharmacological analgesic methods in newborns
Pancham Kumar, Rakesh Sharma, Sukhdev Rathour, Sunidhi Karol, Mohit Karol
Clin Exp Pediatr. 2020;63(1):25-29.   Published online August 16, 2019
Question: Can nonpharmacological methods be used for neonatal pain management.
Finding: Nonpharmacological methods like Sucrose, breastfeeding etc have shown to significantly reduce the pain caused by intramuscular hepatitis B vaccination.
Meaning: Nonpharmacological methods are the safe and cheap potential modalities of analgesia which can be used during mild to moderate pain in newborns.
Critical Care Medicine
Comparative validity of microalbuminuria versus clinical mortality scores to predict pediatric intensive care unit outcomes
Shifa Nismath, Suchetha S. Rao, B.S. Baliga, Vaman Kulkarni, Gayatri M. Rao
Clin Exp Pediatr. 2020;63(1):20-24.   Published online August 12, 2019
Question: Does microalbuminuria predict mortality in pediatric intensive care unit?
Finding: Positive correlation was found between albumin-creatinine ratio and pediatric intensive care unit stay, organ dysfunction and need of inotropes. Area under the receiver operating characteristic curve for albumin-creatinine ratio was comparable to mortality scores.
Meaning: Microalbuminuria is a good predictor of outcome in pediatric intensive care unit and is comparable with mortality scores.
Editorial
Allergy
Hereditary angioedema in childhood
Young Min Ahn
Clin Exp Pediatr. 2020;63(1):18-19.   Published online January 15, 2020
Neonatology (Perinatology)
Prevention and management of pain in the neonatal intensive care unit
Sung Shin Kim
Clin Exp Pediatr. 2020;63(1):16-17.   Published online January 15, 2020
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