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Editorial
Neonatology (Perinatology)
What do we know about the long-term cognitive and behavioral outcomes of school-aged children who were born moderate to late preterm?
Eun Sun Kim
Clin Exp Pediatr. 2020;63(6):215-216.   Published online February 5, 2020
Allergy
Are you sure that it is a drug allergy?
Eun Hee Chung
Clin Exp Pediatr. 2020;63(6):213-214.   Published online June 1, 2020
Review Article
Allergy
Drug Allergy in Children: What Should We Know?
Ji Soo Park, Dong In Suh
Clin Exp Pediatr. 2020;63(6):203-210.   Published online November 12, 2019
The drug allergy “label” may have a lifetime of consequences for a child. Many children with alleged drug allergies are proven to be tolerant to the culprit medication when challenged. The field of drug hypersensitivity is a recently evolving field of research, but studies on its epidemiology and diagnostic tools are lacking in children. Clinical history is significant in the...
Neurology
Genetic tests by next-generation sequencing in children with developmental delay and/or intellectual disability
Ji Yoon Han, In Goo Lee
Clin Exp Pediatr. 2020;63(6):195-202.   Published online November 4, 2019
Developments in next-generation sequencing (NGS) techogies have assisted in clarifying the diagnosis and treatment of developmental delay/intellectual disability (DD/ID) via molecular genetic testing. Advances in DNA sequencing technology have not only allowed the evolution of targeted panels but also, and more currently enabled genome-wide analyses to progress from research era to clinical practice. Broad acceptance of accuracy- guided targeted gene...
Original Article
Cardiology
Importance of pulmonary valve morphology for pulmonary valve preservation in tetralogy of Fallot surgery: comparison of the echocardiographic parameters
Su Jin Choi, Jung Eun Kwon, Da Eun Roh, Myung Chul Hyun, Hanna Jung, Young Ok Lee, Joon Yong Cho, Yeo Hyang Kim
Clin Exp Pediatr. 2020;63(5):189-194.   Published online November 8, 2019
Question: Is echocardiographic examination is useful for surgical method decision in patients with tetralogy of Fallot (TOF)?
Finding: Various echocardiographic parameters serve as predictors for determining surgical methods for TOF patients. However, the PV morphology and tissue characteristics should also be considered.
Meaning: A full dependence on the size of the pulmonary valve annulus (PVA), the z score, and the ratio of the size of PVA to aortic valve annulus or descending aorta surgery may result in inadequate surgical results during TOF total correction.
Critical Care Medicine
Assessment of interhospital transport care for pediatric patients
Krittiya Chaichotjinda, Marut Chantra, Uthen Pandee
Clin Exp Pediatr. 2020;63(5):184-188.   Published online August 29, 2019
Background: Many critically ill patients require transfer to a higher-level hospital for complex medical care. Despite the publication of the American Academy of Pediatrics guidelines for pediatric interhospital transportation services and the establishment of many pediatric transport programs, adverse events during pediatric transport still occur.
Purpose: To determine the incidence of adverse events occurring during pediatric transport and explore their complications...
Editorial
Emergency Medicine
Pediatric transport medicine: a yet unknown territory in Korea
Jeong-Min Ryu
Clin Exp Pediatr. 2020;63(5):182-183.   Published online May 15, 2020
Nephrology (Genitourinary)
Dapsone: a steroid-sparing drug for refractory immunoglobulin A vasculitis?
Jin-Soon Suh
Clin Exp Pediatr. 2020;63(5):178-179.   Published online April 14, 2020
Review Article
Neurology
Factors associated with seizure and cognitive outcomes after epilepsy surgery for low-grade epilepsy-associated neuroepithelial tumors in children
Ara Ko, Joon Soo Lee
Clin Exp Pediatr. 2020;63(5):171-177.   Published online November 13, 2019
Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are responsible for drug-resistant chronic focal epilepsy, and are the second-most common reason for epilepsy surgery in children. LEATs are extremely responsive to surgical treatment, and therefore epilepsy surgery should be considered as a treatment option for LEATs. However, the optimal time for surgery remains controversial, and surgeries are often delayed. In this review, we...
How can neurological outcomes be predicted in comatose pediatric patients after out-of-hospital cardiac arrest?
Hyo Jeong Kim
Clin Exp Pediatr. 2020;63(5):164-170.   Published online October 10, 2019
The prognosis of patients who are comatose after resuscitation remains uncertain. The accurate prediction of neurological outcome is important for management decisions and counseling. A neurological examination is an important factor for prognostication, but widely used sedatives alter the neurological examination and delay the response recovery. Additional studies including electroencephalography, somatosensory-evoked potentials, brain imaging, and blood biomarkers are useful for...
Nephrology (Genitourinary)
Treatment of refractory IgA vasculitis with dapsone: a systematic review
Keum Hwa Lee, Sung Hwi Hong, Jinhae Jun, Youngheun Jo, Woogyeong Jo, Dayeon Choi, Jeongho Joo, Guhyun Jung, Sunghee Ahn, Andreas Kronbichler, Michael Eisenhut, Jae Il Shin
Clin Exp Pediatr. 2020;63(5):158-163.   Published online September 24, 2019
IgA vasculitis, formerly known as Henoch-Schönlein purpura, is a systemic IgA-mediated vasculitis of the small vessels commonly seen in children. The natural history of IgA vasculitis is generally self-limiting; however, one-third of patients experience symptom recurrence and a refractory course. This systematic review examined the use of dapsone in refractory IgA vasculitis cases. A literature search of PubMed databases retrieved...
Letter to the Editor
Cardiology
Differences over 10 years in epidemiologic and clinical features of Kawasaki disease at a single tertiary center
Hyun Su Kim, Suk Won Shin, Bo Geum Choi, Hee Joung Choi
Clin Exp Pediatr. 2020;63(4):157-158.   Published online February 5, 2020
Original Article
Nephrology (Genitourinary)
Variation in clinical usefulness of biomarkers of acute kidney injury in young children undergoing cardiac surgery
Hee Sun Baek, Youngok Lee, Hea Min Jang, Joonyong Cho, Myung Chul Hyun, Yeo Hyang Kim, Su-Kyeong Hwang, Min Hyun Cho
Clin Exp Pediatr. 2020;63(4):151-156.   Published online February 5, 2020
Question: Can clinical usefulness of biomarkers of acute kidney injury vary on the clinical circumstances?
Finding: In young children undergoing cardiac surgery, urine KIM-1/Cr level peaked at 24 hours with significant difference from baseline level and was significantly higher at 6 hours in the AKI group. However, urine NGAL/Cr and IL-18/Cr levels showed no specific trend with time for 48 hours after cardiac surgery.
Meaning: Urine KIM-1/Cr concentration could be considered a good biomarker for early AKI prediction after open cardiac surgery in young children.
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