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Original Article
Usefulness of pelvic ultrasonography for the diagnosis of central precocious puberty in girls
Jung Yu, Ha Young Shin, Sun Hee Lee, You Sung Kim, Jae Hyun Kim
Clin Exp Pediatr. 2015;58(8):294-300.   Published online August 21, 2015

It is difficult to differentiate between central precocious puberty (CPP) and premature thelarche (PT) in girls. The aim of this study was to investigate the diagnostic usefulness of pelvic ultrasonography to distinguish between CPP and PT in girls with early breast development.


This study included girls with early breast development who visited the clinic between January 2012 and December 2013. Clinical,...

Case Report
Asymptomatic maternal 3-methylcrotonylglycinuria detected by her unaffected baby's neonatal screening test
Sun Hee Lee, Yong Hee Hong
Clin Exp Pediatr. 2014;57(7):329-332.   Published online July 23, 2014

3-methylcrotonyl-coenzyme A carboxylase (3MCC) deficiency is an autosomal recessive disorder in which leucine catabolism is hampered, leading to increased urinary excretion of 3-methylcrotonylglycine. In addition, 3-hydroxyisovalerylcarnitine levels increase in the blood, and the elevated levels form the basis of neonatal screening. 3MCC deficiency symptoms are variable, ranging from neonatal onset with severe neurological abnormality to a normal, asymptomatic phenotype. Although...

Original Article
Remission rate and remission predictors of Graves disease in children and adolescents
Sun Hee Lee, Seong Yong Lee, Hye Rim Chung, Jae Hyun Kim, Ji Hyun Kim, Young Ah Lee, Sei Won Yang, Choong Ho Shin
Clin Exp Pediatr. 2009;52(9):1021-1028.   Published online September 15, 2009
Purpose : Medical therapy is the initial treatment for children with Graves disease to avoid complications of other treatments. However, optimal treatment for childhood Graves disease is controversial because most patients require relatively long periods of medical therapy and relapse is common after medication discontinuation. Therefore, this study aimed to search clinical or biochemical characteristics that could be used as...
Growth responses to growth hormone therapy in children with attenuated growth who showed normal growth hormone response to stimulation tests
Jae Hyun Kim, Hey Rim Chung, Young Ah Lee, Sun Hee Lee, Ji Hyub Kim, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2009;52(8):922-929.   Published online August 15, 2009

Purpose:The aim was to investigate the clinical characteristics and responses to growth hormone (GH) therapy in children with attenuated growth who showed normal GH responses to GH stimulation tests (GHST). Methods:The study included 39 patients with height velocity (HV) of less than 4 cm/yr and normal GHST results. Clinical characteristics of patients were analyzed retrospectively. Results:Eleven were born as small for gestational age (SGA)...
Factors for persistent growth hormone deficiency in young adults with childhood onset growth hormone deficiency
Young Ah Lee, Hye Rim Chung, Se Min Lee, Jae Hyun Kim, Ji Hyun Kim, Sun Hee Lee, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2009;52(2):227-233.   Published online February 15, 2009
Purpose : Growth hormone (GH) replacement after retesting is necessary because impairment of body composition and cardiovascular health has been more severe in adult patients with persistent GH deficiency (GHD) from childhood to adulthood. This study aimed to investigate the factors for persistent GHD and define a highly probable group of persistent GHD in young adults with childhood-onset GHD. Methods :...
Methacholine and adenosine 5'-monophosphate challenge tests in children with atopic asthma and with nonatopic asthma, and their relationships to blood eosinophil markers
Sun Hee Lee, Do Kyun Kim, Sun Hee Choi, Young Yull Koh
Clin Exp Pediatr. 2006;49(11):1216-1222.   Published online November 15, 2006
Purpose : Though atopic and nonatopic asthma have different clinical manifestations, bronchial hyperresponsiveness (BHR) and airway inflammations are common characteristics of them. We investigated BHR to both methacholine and adenosine 5'-monophosphate (AMP), and their relationships with blood eosinophil markers in nonatopic asthma as well as atopic asthma. Methods : We studied 116 children (82 atopics; 34 nonatopics) with mild to moderate...
Case Report
Ivemark’s Syndrome 4 Cases
Soon II Lee, Woo Gill Lee, Bu Kyung Kang, Sun Hee Lee, Sung Kyu Lee, Dong Shik Chin, Duk Jin Yun
Clin Exp Pediatr. 1975;18(6):468-472.   Published online June 30, 1975
Ivemark’s syndrome is rare disease and characterized by congenital absence of the spleen as sociated with characteristic group of anomalies of the cardiovascular and gastroenteric systems. We had experienced 4 cases of Ivemark’s yndrome: Case 1 had asplenia, situs inversus, dextrocardia, ASD, and pulmonary stenosis; Case 2 had asplenia, bilobulated liver, centraly located stomach but deviated to right side, single...
Case Report
A Case of Total Anomalous Pulmonary Venous Return(A case report and review of literature)
Woo Gill Lee, Duk Hee Kim, Sun Hee Lee, Dong Shik Chin
Clin Exp Pediatr. 1973;16(2):151-155.   Published online February 28, 1973
We had a case of total anomalous pulmonary venous drainage, a 10 years old schoolboy who admitted to our Severance Hospital with chief problems of exertional dyspnea, palpitation, and known congenital heart disease since infancy. We confirmed this case as a total anomalous pulmonary venous connection to persistent left inno minate vein which drains into right atrium, atrial septal defect (secundum...
Original Article
Throat Culture in Respiratory Tract Infections in Infancy and Childhood
Sung Soo Lee, Sun Hee Lee, Ki Young Lee, Duk Jin Yun
Clin Exp Pediatr. 1972;15(11):1030-1036.   Published online November 30, 1972
A group of 980 cases of respiratory tract infections in infancy and children admitted to Severance Hospital during the 4 years from June, 1967 to May, 1971 were studied, and bacteriologic studies in each respiratory disease by means of throat cultures were evaluated. The following results were obtained: 1. Total number of bacteria isolated from respiratory patients were 1,708 in which number of Potential ...
Case Report
Two Cases of 18 Trisomy Syndrome
Chang Jun Coe, Sun Hee Lee, Kyung Sook Park, Duk Jin Yun
Clin Exp Pediatr. 1972;15(2):161-164.   Published online February 28, 1972
There are two cases concerning 18 trisomy syndrome, which have been confirmed by chromosome culture at Severance Hospital, Yonsei University. This is the first case report of 18 trisomy syndrome in Korea. Case 1: A 2. 3kg weight premature female infant have born at 36 weeks of gestation at Severane Hospital. No specific history was obtainable except polyhydramnios in antenatal period. On...
Original Article
Study on the Effect of Phototherapy on Neonatal Jaundice
Sun Hee Lee
Clin Exp Pediatr. 1971;14(6):383-388.   Published online June 30, 1971
In 1958, Cremer had demonstrated that serum ibilirubin concentration of new born infant can be reduced by exposure to light. There were manyVeports about the effect of phototherapy on hyperbilirubinemia and premature baby. A controlled clinical trial has been carried out among 48 full term infant who were selected by random sampling to test the effectiveness of artificial 300 foot candle...
Case Report
Gastroschisis of a Premature Infant(A Case Report and Review of the Literature)
Sun Hee Lee, Chung Hee Kim, Kyung Sook Park
Clin Exp Pediatr. 1970;13(1):49-50.   Published online January 31, 1970
A females premature baby was delivered with evisceration of internal organs such as liver, stomach, small and large intestines at Severance Hospital. Umbilical cord was normally located just below the defect. The defect was about 6 cm in diameter above umbilicus. There was no membrane enclosing the eviscerated organs but yellowish exudate was attached to exposed surface. The margin of...
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