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Original Article
Analysis on the cause of eosinophilia in a neonatal intensive care unit
Jeoung Young Kim, Hyo Bin Im, Min Jung Sung, Sang Hee Son, Son Sang Seo
Clin Exp Pediatr. 2010;53(1):28-32.   Published online January 15, 2010
Purpose : Although eosinophilia is a common laboratory finding in many neonatal intensive care units (ICUs), its causative mechanisms remain obscure. We aimed to determine the causes of eosinophilia in the neonatal ICU environment. Methods : Serial eosinophil counts were determined weekly for 288 hospitalized, appropriately grown neonates. Infants were divided into four groups according to gestational age, and the...
Case Report
Isolated 3-Methylcrotonyl CoA Carboxylase Deficiency Detected by Newborn Screening Program Using Tandem Mass Spectrometry
Ju Young Kwak, Jun Young Park, Kyung A Nam, Sang Hi Son, Son Sang Seo
Clin Exp Pediatr. 2005;48(5):561-564.   Published online May 15, 2005
Isolated deficiency of 3-methylcrotonyl CoA carboxylase is a rare disorder of the catabolic pathway for leucine and many patients have mild symptoms or no symptom. However, the introduction of tandem mass spectrometry in newborn screening has revealed an unexpectedly high incidence of this disorder. We report an asymptomatic premature infant with isolated 3-methylcrotonyl CoA carboxylase deficiency detected by newborn screening...
Original Article
The Efficacy of Nebulized 3 Percent Hypertonic Saline Solution and Fenoterol in Infants with Bronchiolitis
Joon Young Park, Young Mi Jeong, Soo Jin Jeong, Son Sang Seo
Clin Exp Pediatr. 2005;48(5):518-522.   Published online May 15, 2005
Purpose : To evaluate the effect of inhaled hypertonic saline solution in hospitalized infants with bronchiolitis. Methods : A randomized double blind trial was performed from October 2003 to May 2004. A total of eighty patients <1 year of age with a clinical diagnosis of acute viral bronchiolitis were enrolled and assigned to receive either of the following : inhalation of...
The Efficacy of Nebulized Epinephrine Versus Fenoterol in Hospitalized Infants with Acute Bronchiolitis
Sang Hee Lee, Kyung Ah Nam, Ji Youn Choi, Meen Jung Kim, Son Sang Seo
Clin Exp Pediatr. 2004;47(9):953-958.   Published online September 15, 2004
Purpose : Acute bronchiolitis is a lower respiratory tract disease, resulting from inflammatory obstruction of the small airway. The main treatment of acute bronchiolitis is supportive but, numerous investigators have examined the efficacy of beta agonist as bronchodilators. In acute bronchiolitis, mucosal edema in the bronchioles may be an important cause of airway obstruction therefore, an alpha and beta agonist...
The Diagnostic Value of Gross Bloody Stool on Intussusception
Kyung Ah Nam, Sang Hee Lee, Sang Hee Son, Su Jin Jung, Son Sang Seo
Clin Exp Pediatr. 2004;47(8):851-854.   Published online August 15, 2004
Purpose : To evaluate the diagnostic value of gross bloody stools as a predictor of intussusception. Methods : We reviewed 159 cases retrospectively that had an ultrasound examination for diagnosis of intussusception from January 2001 to December 2003 at Ilsin Christian Hospital. We compared each symptom and assessed the diagnostic value of gross bloody stools in the patients with suspected intussusception. Results...
Case Report
A Case of Maple Syrup Urine Disease Associated with Acrodermatitis Enteropathica-like Syndrome Due to Iisoleucine Deficinecy During Diet Therapy
Ki Hyang Moon, Oh Sook Gwon, Jung Im Lee, Seong Woo Rho, Seong Sook Jeon, Son Sang Seo
Clin Exp Pediatr. 2001;44(4):469-474.   Published online April 15, 2001
Maple syrup urine disease(MSUD) is an autosomal recessive disorder involving the metabolism of the branched-chain amino acids(BCAA) such as leucine, isoleucine and valine. The disorder is due to a defect in branched-chain α-ketoacid dehydrogenase(BCKAD) and the classic form causes rapid progressive and overwhelming illness beginning in the first weeks of life, present with poor feeding, lethargy, change in muscle tone,...
Original Article
Comparison of Preventive Effect of RDS and Neonatal Morbidity between Antenatal Dexamethasone versus Ambroxol Administration
Eun Jeong, Kim, Seong Sook Jeon, Son Sang Seo
Clin Exp Pediatr. 2000;43(1):13-22.   Published online January 15, 2000
Purpose : Antenatal dexamethasone administration is associated with a significant lowering respiratory distress syndrome(RDS) incidence, but can increase neonatal infection. Ambroxol has been accepted as an alternative treatment to dexamethasone and is of at least equal efficacy but without adverse reaction. The aim of this study was to evaluate the effectiveness of ambroxol versus dexamethasone in RDS incidence and neonatal...
Gastric Emptying Time in Preterm Infents : Comparison between Breast Milk and Formula Milk
Seong Woo Roh, Seong Sook Jeon, Son Sang Seo, Jeong Mi Kwon
Clin Exp Pediatr. 1999;42(3):324-331.   Published online March 15, 1999
Purpose : Failure of adequate gastric emptying frequently interferes with successful enteral nutrition in infants. Study of gastric emptying in preterm infants has been hampered by the absence of a suitable and, valid technique, but ultrasonic assessment is well tolerated by infants. The aim of this study is to compare gastric emptying rates of breast milk and formula within preterm...
Bone Mineral Metabolism and Rickets Compared between Fortified Human Milk and Preterm Formula Feeding in Prematurity
Hong Sun Ju, Eun Young Jeong, Seong Sook Jeon, Son Sang Seo
Clin Exp Pediatr. 1998;41(11):1476-1483.   Published online November 15, 1998
Purpose : To compare the effect of breast milk containing fortifier with preterm formula on bone mineral metabolism in premature infants, we evaluated the state of bone mineralization, biochemical alteration and the frequency of rickets during the first five months of life. Methods : Fourteen fortified breast milk-fed infants and eleven preterm formula-fed infants who were born at Il-Sin...
Nitroglycerin Treatment in Persistent Pulmonary Hypertension of the Newborn
Ji Sook Kim, Sung Sook Jeon, Son Sang Seo
Clin Exp Pediatr. 1997;40(11):1529-1536.   Published online November 15, 1997
Purpose : Persistent pulmonary hypertension(PPHN) of the newborn has been treated with some vasodilators including tolazoline. But these drugs have many side effects, especially systemic hypotension . To investigate the usefulness of the nitroglycerin as a specific vasodilator with few side effects, this study was done. Methods : Nitroglycerin was administered within 1st one day after birth in 8 newborn infants who were diagnosed as...
Case Report
A Case of Neuronal Heterotopia
Jeong Hae Joo, Eun Joo Seok, Min Jeong Kim, Son Sang Seo
Clin Exp Pediatr. 1997;40(8):1173-1177.   Published online August 15, 1997
Neuronal migrational disorders of the brain represent abnormalities in the formation of the neocortex caused by faulty migration of the subependymal neuroblasts. The neuroblasts normally migrate between the sixth and 15th gestational week and in doing so form the six-layered neocortex. When the migration does not occur in a normal fashion the resultant brain anomalies include lissencephaly, pachygyria, schizencephaly, hemimegalencephaly, heterotopia, and polymicrogyria. Neuronal heterotopia is...
Original Article
Effect of Indomethacin Therapy in Prematurity with Patent Ductus Arteriosus:study of Its Effectiveness in Treatment Modality
Yun Kyeong Bae, Seong Woo Roh, Min Jeong Kim, Son Sang Seo
Clin Exp Pediatr. 1996;39(9):1239-1246.   Published online September 15, 1996
Purpose : Conventional indomethacin therapy(0.2mg/kg every 12 hours for three doses) has been used for closure of PDA. The effect of prolonged low dose of indomethacin therapy(0.1mg/kg daily for six days)had been reported in foreign country but, nothing had been reported in our country. So we attempted this study to examine effects of these two methods. Methods : Forty one infants with PDA of...
Case Report
Two Cases of Neonatal Adrenal Hemorrhage
Kyeong Hye Jeong, Sung Suk Jeon, Ok Sung Jeong, Son Sang Seo, Jung Mee Kweon
Clin Exp Pediatr. 1995;38(10):1411-1416.   Published online October 15, 1995
Neonatal adrenal hemorrhage is not uncommon due to its relative large size and vascularity, thus making it vulnerable to traumatic and asphyxial injuries. It뭩 etiology is unknown, but postulated etiologies include maternal diabetes, obstetric trauma, asphyxia, thrombocytopenia and coagulation defect. Clinical manifestations ate those of a paplable mass in the affected flank, anemia and jaundice. Hypoglycemia, hypotension and hypovolemia may...
Original Article
A Clinical Observation of 23 Cases of Necrotizing Enterocolitis
Ok Young Kim, Eun Ju Jeong, Min Jeong Kim, Mi Yeon Park, Son Sang Seo
Clin Exp Pediatr. 1995;38(7):886-894.   Published online July 15, 1995
Purpose : We observed risk factors, clinical findings, diagnosis and treatment of NEC in 23 cases in order to try to prevent developement of, and improve the prognosis of necrotizing enterocolitis(NEC) in the future. Methods : 23 cases of NEC who were admitted to the NICU of Ilsin Christian Hospital between Jan 1992 and June 1994 were studied. Data about birth...
Clinical Study on Twins
Sang Hee Lee, Ok Young Kim, Son Sang Seo
Clin Exp Pediatr. 1993;36(12):1663-1671.   Published online December 15, 1993
Clinical survey was performed on 413 cases of twin pregnancies and their 816 twin babies who were born at IlSin Christian Hospital during 5years from January 1987 to December 1991. The result of study was as follows : 1) There was 413 twin pregnancies among 40,711 deliveries, so the incidence of twins was 1 : 98.6. Average male-female sex ratio of twins...
A Clinical Study of Congenital Anomalies in Births associated with Hydramnios
Eun Sil Shin, Min Jeong Kim, Ock Seung Jeong, Son Sang Seo
Clin Exp Pediatr. 1993;36(9):1227-1235.   Published online September 15, 1993
A study was made in the congenital anomalies in 137 babies born to 120 mothers with hydramnios, delivered at Ilsin Christian Hospital between Jan. 1st 1981 and Dec. 31th 1990. The results were as follows; 1) The incidence of hydramnios was 16/1000 deliveries, 120 cases in total 73,129 deliveries. 137 infants was born and of...
A Clinical Study on Neonatal Exchange Transfusion
Eun Ju Park, Eun Wui Kim, Yang Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1993;36(4):469-477.   Published online April 15, 1993
Clinical observation was perfumed on 81 cases who were received exchange transfusion at Ilsin Christian Hospital from January, 1986 to December, 1990. The results obtained were as follows: 1) Among 6,388 cases of neonatal jaundice, the exchange transfusion was performed on 81 cases(1.27%) 2) There was no sex predominance (male 40, female 41). The birth weight of 75 cases(92.6%) ranged from 2,500 gm...
A Clinical Survey of Prematurity
Jee Won Lee, Sang Hee Lee, Ock Seung Jeong, Son Sang Seo
Clin Exp Pediatr. 1993;36(3):364-370.   Published online March 15, 1993
A clinical observaton was performed on 2,122 cases of premature infants who were admitted to Ilsin Christian during the past 5 years from Jan. 1986 to Dec. 1990. The results were as follows ; 1) The incidence of prematurity was 5.7%, overall mortality rate was 15.8%, and the sex ratio of male to female was 1.5:1. ...
Neonatal Mortality
Min Jeong Kim, Eun Eui Kim, Ock Seung Jeong, Son Sang Seo
Clin Exp Pediatr. 1993;36(3):356-363.   Published online March 15, 1993
A review of all 919 perinatal deaths occuring in Il Sin Christian Hospital From 91985 to 1989 was carried out. The results of clinical analysis were as follows : 1) The overall perinatal mortality rate was 26.30 per 1,000 birth. 2) The perinatal mortality rate was lowest in the gestation group between 37~41 week and in the weight group between 2,501~4,000gm. 3) The perinatal...
Clinical Study on Infants of Diabetic Mothers
Eun Eui Kim, Min Jeong Kim, Yang Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1993;36(3):347-355.   Published online March 15, 1993
A clinical observation was performed on the 80 cases of neonates born from diabetic mothers among the total of 34,936 neonates delivered at Il Sin Christian Hospital from January 1985 to December 1989. The results were as follows : 1) The incidence of infants of diabetic mothers was 0.23%, among whom gestational diabetic mothers were 63 cases(78.7%) and overt diabetic mothers...
A case of a variant of Pierre Robin syndrome -cerebrocostomandibular syndrome-.
Hye Jin Lee, Eun Jin Mun, Ock Seung Jeong, Son Sang Seo, Jeong Ja Kang
Clin Exp Pediatr. 1991;34(7):1022-1028.   Published online July 31, 1991
We experienced a case of cerebrocostomandibular syndrome in newborn consisted of costal deficiency, and micrognathia. It is a variant of Pierre Robin syndrome, and cleft palate and glossoptosis are frequently present. Respiratory difficulty due to rib dysplasia result in poor prognosis for survival. Brief review of literature was made.
A clinical study of congenital hypertropic pyloric stenosis.
Eun Chin Mun, Hae Jin Lee, Son Sang Seo, Jung Woo Yang
Clin Exp Pediatr. 1991;34(5):637-644.   Published online May 31, 1991
This study was a review and clinical analysis of 77 cases of congenital hypertrophic pyloric stenosis at II Sin Christian Hospital from Jan. 1980. to Mar. 1990. The result was as follows. 1) At age distribution, the most prevalent age group was between 4 weeks and 6 weeks, and ratio of male to female was about 3.8:1. 2) Among 77 cases, the first bom was most affected...
A Clinical Study on Neonatal Polycythemia.
Gyu Ja Jeong, Hye Jin Lee, Yaung Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1990;33(11):1495-1502.   Published online November 30, 1990
We observed 34 cases of newborn, who were diagnosed as having polycythemia, out of 3,312 newborns who were admitted to our nursery between January 1, 1989 and December 31, 1987. The following results were obtained; 1) The incidence of neonatal polycythemia was 1% and male to female ratio was 1.8:1. The birth weight of 2000 g to 2500 g was the most common (35.3%). 2) Gestational age...
A Clinical Observation of Congenital Syphilis.
Soo Mi Baek, Eun Chin Moon, Ock Seung Jeong, Son Sang Seo
Clin Exp Pediatr. 1990;33(10):1326-1332.   Published online October 31, 1990
The authors studied 75 cases of congenital syphilis in the newborn treated at II Sin Christian Hospital from January 1983 to December 1987. The results were as follows; 1) The incidence of syphilis among the admitted pregnant women for delivery was 0.62%. 2) The incidence of neonatal syphilis from the 208 syphilis mothers was 36.1%. 3) The incidence of prematurity and low birth weight neonate among congenital syphilitic...
Clinical Studies of Human Rotavirus Gastroenteritis.
Eun Ok Rhee, Nam Joo Hwang, Yaung Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1989;32(10):1369-1376.   Published online October 31, 1989
A clinical study of 92 HRV Antigen positive patients among 270 children admitted to the pediatric department of II Sin Christian Hospital because of diarrhea between Sept. 1st 1986 and Aug. 31st 1987 is reported. All cases were detected by the ELISA method. 1) All patients were under 2 year of age with the peak incidence being between 6 month and 1 year of age and...
Statistical Study of Perinatal Autopsy.
Gyu Ja Jung, Su Mi Back, Ock Sung Jung, Son Sang Seo, Hye Kyoung Yoon
Clin Exp Pediatr. 1989;32(9):1195-1201.   Published online September 30, 1989
Recently, the incidence of perinatal death in this country has decreased by improved antenatal care and resuscitative management, but is still higher than that of developed country. A number of studies on perinatal death have dealed with mainly statistical and clinical aspect. We studied about perinatal death in order to prove more accurate cause of death by autopsy. The subjects of our study were...
A Case of Metatropic Dwarfism.
Eun Ok Rhee, Nam Joo Hwang, Yaung Sook Choi, Son Sang Seo, Hye Kyoung Yoon
Clin Exp Pediatr. 1989;32(8):1167-1173.   Published online August 31, 1989
Metatropic dwarfism is rare skeletal dysplasia characterized by short extremities, bulbous enlarge- ment of the joints, joint limitation and progressive and ultimately severe kyphoscoliosis. We have experienced one case of metatropic dwarfism. The diagnosis was established by clinical, radiological and pathologic findings. The patient was died six days after delivery. A brief review of literature was made.
Clinical Survey of Very low Birth Weight Infant.
Seong Sook Jeon, Wha Mo Lee, Yang Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1988;31(9):1120-1125.   Published online September 30, 1988
A clinical survey of Very Low Brith Weight Infant was done on 27,170 infants bom at II Sin Christian Hospital between Jan. 1 1983 and Dec. 31 1986. The results were as follows; 1) The incidence of VLBWI in the 27,170 births was 1.0%, and there was no annual variation. 2) Among 10,749 multiparaty there was a higher incidence of VLBWI (1.4%) compared to that in primiparity...
A Clinical Ovservation of Tetanus Neonatorum.
Gyeong Hye Jung, Hyo Sin Kim, Ock Seung jeong, Son Sang Seo
Clin Exp Pediatr. 1988;31(8):992-998.   Published online August 31, 1988
A clinical study in 75 cases who were hospitalized and diagnosed as neonatal tetanus at II Sin Christian Hospital during the last 10 years (1976-1985) is reported. The results were as follows; 1) The mean annual incidence was 0.29% and the overall mortality rate was 29.4%. 2) Sex ratio of male to female was 1.6:1. 3) Home delivery without sanitory facilities was the most common problem (86.5%). 4) Most of...
Clinical Survey of Congenital Malformation.
Seong Sook Jeon, Hyo Sin Kim, Yaung Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1987;30(5):491-498.   Published online May 31, 1987
A clinical survey of congenital malformations was done on 36,689 infants bom at II Sin Christian Hospital between Jan. 1st 1981 and Dec. 31 1985. The results were as follows, 1) The incidence of congenital malformations in the 36,689 births was 2.7%, and the total number of malformations was 1,144 including multiple anomalies. 2) Among 18,915 male births, the...
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