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Case Report
Chronic inflammatory demyelinating polyneuropathy in children: a report of four patients with variable relapsing courses
Soo Jin Chang, Ji Hyun Lee, Shin Hye Kim, Joon Soo Lee, Heung Dong Kim, Joon Won Kang, Young Mock Lee, Hoon-Chul Kang
Clin Exp Pediatr. 2015;58(5):194-198.   Published online May 22, 2015

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronically progressive or relapsing symmetric sensorimotor disorder presumed to occur because of immunologic antibody-mediated reactions. To understand the clinical courses of CIDP, we report variable CIDP courses in children with respect to initial presentation, responsiveness to medical treatment, and recurrence interval. Four patients who were diagnosed with acute-onset and relapsing CIDP courses at...

Review Article
Effects of phytoestrogen on sexual development
Shin Hye Kim, Mi Jung Park
Clin Exp Pediatr. 2012;55(8):265-271.   Published online August 23, 2012

Phytoestrogen is an estrogenic compound that occurs naturally in plants. The most common sources of phytoestrogen are soybean products, which contain high levels of isoflavones. This compound, which has structural similarity with estrogen, can act as an estrogen receptor agonist or antagonist. Animal studies provide evidence of the significant effects of phytoestrogen on sexual development, including altered pubertal timing, impaired...

Original Article
Effects of human growth hormone on gonadotropin-releasing hormone neurons in mice
Janardhan P. Bhattarai, Shin Hye Kim, Seong Kyu Han, Mi Jung Park
Clin Exp Pediatr. 2010;53(9):845-851.   Published online September 13, 2010
Purpose

Recombinant human growth hormone (rhGH) has been widely used to treat short stature. However, there are some concerns that growth hormone treatment may induce skeletal maturation and early onset of puberty. In this study, we investigated whether rhGH can directly affect the neuronal activities of of gonadotropin-releasing hormone (GnRH).

Methods

We performed brain slice gramicidin-perforated current clamp recording to examine the direct...

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