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Review Article
General Pediatrics
Quality improvement in pediatric care
Moon Sung Park
Clin Exp Pediatr. 2018;61(1):1-5.   Published online January 22, 2018

We often overlook the importance of several safety issues such as identification of patients, timeout procedure, hand hygiene, handoff communication, and many others. This ignorance, along with many other issues, leads to medical error being ranked as a third leading cause of death in the U.S. Consequently, quality improvement (QI) has become one of the major subjects in healthcare despite...

Case Report
Neonatology (Perinatology)
Successfully treated infective endocarditis caused by methicillin-resistant Staphylococcus Aureus in extremely low birth weight infant
Sehwa Jung, Kyung Uk Jeong, Jang Hoon Lee, Jo Won Jung, Moon Sung Park
Clin Exp Pediatr. 2016;59(2):96-99.   Published online February 29, 2016

Survival rates of preterm infants have improved in the past few decades, and central venous catheters play an important role in the intensive medical treatment of these neonates. Unfortunately, these indwelling catheters increase the risk of intracardiac thrombosis, and they provide a nidus for microorganisms during the course of septicemia. Herein, we report a case of persistent bacteremia due to...

Original Article
The efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia
Sang Bum Kim, Jang Hoon Lee, Juyoung Lee, Seung Han Shin, Ho Sun Eun, Soon Min Lee, Jin A Sohn, Han Suk Kim, Byung Min Choi, Min Soo Park, Kook In Park, Ran Namgung, Moon Sung Park
Clin Exp Pediatr. 2015;58(9):347-353.   Published online September 21, 2015
Purpose

The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD).

Methods

The Interventional study was designed as a multicenter, prospective, and randomized trial, with open labeled and parallel-experimental groups, 66 infants were enrolled and allocated to either the case group (n=30) or the control group (n=36) based on gestational age (GA)....

The control of invasive Candida infection in very low birth weight infants by reduction in the use of 3rd generation cephalosporin
Yu Jin Chang, Il Rak Choi, Won Sub Shin, Jang Hoon Lee, Yun Kyung Kim, Moon Sung Park
Clin Exp Pediatr. 2013;56(2):68-74.   Published online February 25, 2013
Purpose

To evaluate the effectiveness of new management policies on the incidence of invasive Candida infections

Methods

This observational study involved a retrospective analysis of the patients' medical records. In total, 99 very low birth weight infants, who were admitted to the neonatal intensive care unit at Ajou University Hospital from January 2010 to December 2011, were enrolled for the study. Period I,...

Early neurodevelopment in very low birth weight infants with mild intraventricular hemorrhage or those without intraventricular hemorrhage
Il Rak Choi, Jang Hoon Lee, Moon Sung Park, Ji Yeon Kim, Kyu Hee Park, Gun-Ha Kim, So-Hee Eun
Clin Exp Pediatr. 2012;55(11):414-419.   Published online November 23, 2012
Purpose

This study aimed to assess early development in very low birth weight (VLBW) infants with mild intraventricular hemorrhage (IVH) or those without IVH and to identify the perinatal morbidities affecting early neurodevelopmental outcome.

Methods

Bayley Scales of Infant Development-II was used for assessing neurological development in 49 infants with a birth weight <1,500 g and with low grade IVH (≤grade II) or...

Pharmacokinetics of Cyclosporine A and Its Therapeutic Effect in Children with Renal Diseases
Woo Sung Chun, Min-Soo Park, Jae Seung Lee, Juyun Yu, Moon Sung Park, Ki-Soo Pa
Clin Exp Pediatr. 2004;47(2):193-203.   Published online February 15, 2004
Purpose : To know the body handling properties and anti-proteinuric effect of cyclosporine A(CsA) in children with renal diseases, 34 patients with nephrotic syndrome or glomerular diseases were included to treatment trials and evaluated. Methods : Microemulsion formula CsA, 5 mg/kg/day was administered orally in two divided doses for 9.3?.6 months. Pharmacokinetic studies of CsA were done twice at beginning and...
Medical Lecture Course
Clara Cell Secretory Protein
Moon Sung Park
Clin Exp Pediatr. 2002;45(12):1477-1483.   Published online December 15, 2002
Original Article
Clinical Trial of Domestically Developed Bovine Lung Surfactant YY-38 in Neonatal Respiratory Distress Syndrome
Chul Lee, Jeong Nyun Kim, Min-Soo Park, Moon Sung Park, Shin Won Yoon, Wook Chang, Ran Namgung, Kook In Park, Dong-Gwan Han
Clin Exp Pediatr. 1999;42(4):472-483.   Published online April 15, 1999
Purpose : We previously reported modified bovine lung surfactant YY-38(NewfactanⓇ) had a low surface tension, good hysteresis, and exhibited good pressure-volume curve in animal experiment (J Korean Pediatr Asso 1997;40:771-85). We performed multicenter clinical trial of NewfactanⓇ in neonatal RDS. Methods : Seventy-seven infants with RDS(GA 31.8¡¾2.9 wks and BW 1,809¡¾592 gm) in 4 NICU were enrolled. After administration of...
Case Report
A Case of FGFR2 Exon Ⅲc Mutation in Crouzon Syndrome
Seon Chan Bae, Eun Ha Lee, Moon Sung Park, Si Houn Hah, Chang Ho Hong
Clin Exp Pediatr. 1998;41(12):1717-1721.   Published online December 15, 1998
Crouzon syndrome, an autosomal dominant disorder, has characteristic features of craniosynostosis, hypertelorism, exophthalmos, maxillary hypoplasia and relative mandibular prognathism. Mutations of fibroblast growth factor receptor 2(FGFR2) gene are associated with craniosynostotic conditions, such as Crouzon syndrome, Jackson-Weiss syndrome, Pfeiffer syndrome, Apert syndrome and Beare-Stevenson cutis gyrata. We found one child with common morphological features of Crouzon syndrome. Interestingly, she...
Meckel-Gruber syndrome
Jung Seo Park, Ji Yoen Lee, Sun Chan Bae, Moon Sung Park, Jung Seon Kim, Si Houn Hahn, Chang Ho Hong
Clin Exp Pediatr. 1998;41(6):856-860.   Published online June 15, 1998
Meckel-Gruber syndrome is a multiple malformation syndrome featuring occipital meningoencephalocele, multicystic dysplasia of kidney, cystic and fibrotic change of liver, polydactyly, and other characteristics inherited by the autosomal recessive trait. We exprienced a case of Meckel-Gruber syndrome in a newborn male diagnosed clinically and confirmed pathologically. Abnormalities of the fetus were found prenataly by ultrasonogram, and subsequently the baby was...
Original Article
Physical and Biological Activity of Domestic Product of Modified Bovine Lung Surfactant
Chul Lee, Min Soo Park, Moon Sung Park, Jung Nyeon Kim, Jong Wook Lee, Kwang Hyun You, Won Jae Kwag, Kook In Park, Ran Nam gung, Dong Gwan Han
Clin Exp Pediatr. 1997;40(6):771-785.   Published online June 15, 1997
Purpose : Neonatal respiratory distress syndrome is caused by the deficiency of lung surfactant in premature babies. For the treatment of RDS at present surfactants such as Surfacten․ (Tokyo-Tanabe Co., Japan) and Exosurf․ (Wellcome Co., USA) are used. As awarded the grant from the Ministry of Science and Technology for a model research project of Medium-Technology program, we have modified (supplemented) the bovine lung...
Case Report
A Case of Tethered Cord Syndrome
Sook Yeong Jeon, Ki Hyoung Lee, Moon Sung Park, Ok Wha Kim
Clin Exp Pediatr. 1996;39(11):1636-1640.   Published online November 15, 1996
Tethered cord syndrome is one of the spinal dysraphism with low-lying conus medullaris frequently associated with spinal lipoma, diastematomyelia and thick filum. The clinical manifestation is variable from no overt symptoms for a long time to back pain, scoliosis, progressive neurological deficit of legs and incontinence. Therefore the diagnosis requires a strong clinical suspicion and aggressive investigation. We experienced a case of 1 day-old male...
Original Article
The Therapeutic Effects of Dexamethasone Therapy in Neonate with Bacterial Meningitis
Eun Gyung Lee, Kook In Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Kwan Han
Clin Exp Pediatr. 1995;38(5):602-611.   Published online May 15, 1995
Purpose : In experimental models of meningitis and in children with meningitis, dexametha-sone has been shown to reduce meningeal inflammation and to improve the outcome of disea-se. We studied the effects of dexamethasone administration in neonates(<2 month-old) with b-acterial meningitis. Methods : We retrospectively reviewed the medical records of 30 neonates admitted to the nursery, the Yonsei University College of Medicine...
Case Report
A Case of Hemimegalencephaly with Intraventricular Hemorrhage and Multifocal Intraparenchymal Hemorrage on Deep White Matter of Periventricular Area
Jin Sung Ko, Kook In Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwang Han, Choon Sik Yoon
Clin Exp Pediatr. 1995;38(4):561-566.   Published online April 15, 1995
Hemimegalencephaly is a rare congenital anomaly characterized by a intractable seizure an infantile death. This disease is a migrational disorder with enlargement of unilateral hemisphere, abnormal gyration of the cortex, the presence of large and atypical neuron, hetero trophic neuron at subcortical area and proliferation of astrocyte ect. We observed a neonate with neonatal seizure, and the radiological evaluation revealed abnormal...
Original Article
Neonatal Neurosonographic Findings, Cerebral Doppler and Electrophysiological Findings in Infants with Motor Idsturbance
Jae Kwang Kim, Kook In Park, Chang Il Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Kwan Han
Clin Exp Pediatr. 1995;38(4):445-460.   Published online April 15, 1995
Purpose : Neurosonography, cerebral doppler and electrophysiological study are valuable in predicting neurodevelopmental outcome. The purpose of this study was to analyze characteristics of neonatal neurosonographic findigs, cerebral doppler and electrophysiological findings in infants withmotor disturbance. Methods : The subjects were 33 infants hospitalized at Yonsei Severance Medical Center NICU from January, 1990 to December, 1992. 19 of these patients underwent...
Risk Factors of Bronchopulmonary Dysplasia in Premature Infants Treated with Mechanical Ventilation and Restrictive Fluid Therapy
Min Soo Park, Kook In Park, Hye Jung Choo, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(10):1357-1363.   Published online October 15, 1994
In addition to many of the widely accepted risk factors of bronchopulmonary dysplasia(BPD), such as prematurity, oxygen toxicity, barotrauma, and infection, the amount of fluid intake during the early phase of life has recently been reported to be an important factor, especially the amount of colloid. Forty-one premature infants who were admitted to the NICU of Severance Hospital, Yonsei University...
Effect of Glucocorticoid-Induced Hyperglycemia on Preventing Hypoxic-Ischemic Brain Damage by Dexamethasone in Neonatal Rat
Kook In Park, Tae Seung Kim, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(8):1035-1047.   Published online August 15, 1994
Purpose : We evaluated the protective effect of dexamethasone (DX) administration on brain damage produced in a perinatal model of cerebral hypoxia-ischemia in the rat. Since hyperglycemia has been shown to reduce hypoxic-ischemic brain injury (HI) in immature rat, we investigated the role of glucocorticoid-induced hyperglycemia in the neuroprotective mechanism of DX. Methods : Hypoxic-ischemic brain injury in 7-day-old rats was...
Mechanism of Impaired Growth Hormone Response in Children with Simple Obesity
Moon Sung Park, Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1994;37(4):457-463.   Published online April 15, 1994
Obesity is associated with an impairment of the hormone secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown, To determine whether obesity is associated with a chronic state of tonic somatostatin, several tests with growth hormone stimuli such as GHRH (1㎍/kg), clonidine (150㎍/m2) and Resular insulin (0.1U/kg, subcutaneously), to obese subjects and...
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