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Original Article
Correlation between the morning hypertension on ambulatory blood pressure monitoring and the left ventricular mass in children
Hyun Jung Kim, Kyung Hee Kim, Hong Ryang Kil
Clin Exp Pediatr. 2014;57(9):403-409.   Published online September 30, 2014
Purpose

Although high morning blood pressure (BP) is known to be associated with the onset of cardiovascular events in adults, data on its effects in children with hypertension are limited. Our retrospective study aimed to define the clinical characteristics of children with morning hypertension (MH) and to determine its associated factors.

Methods

We reviewed 31 consecutive patients with hypertension, confirmed by the ambulatory...

Cardiovascular risk factors of early atherosclerosis in school-aged children after Kawasaki disease
Hyun Jeong Cho, Soo In Yang, Kyung Hee Kim, Jee Na Kim, Hong Ryang Kil
Clin Exp Pediatr. 2014;57(5):217-221.   Published online May 31, 2014
Purpose

The aim of this study was to determine whether school-aged children with Kawasaki disease (KD) have an increased risk for early atherosclerosis.

Methods

The study included 98 children. The children were divided into the following groups: group A (n=19), KD with coronary arterial lesions that persisted or regressed; group B (n=49), KD without coronary arterial lesions; and group C (n=30), healthy children....

Antithrombin III in the Diagnosis and Treatment of Disseminated Intravascular Coagulation in Premature Infants
Su Jin Cho, Hye Ryung Choi, Young Mi Hong, Kyung Hee Kim, Keun Lee, Eun Ae Park
Clin Exp Pediatr. 2004;47(7):740-745.   Published online July 15, 2004
Purpose : We evaluated the diagnostic implications and therapeutic efficacy of antithrombin III(AT III) in the disseminated intravascular coagulation(DIC) of premature infants. Methods : Ninety-two premature infants diagnosed with DIC and treated with AT III from March, 2000 to May, 2003 were retrospectively reviewed. Clinical manifestations, complete blood counts, coagulation tests, and AT III levels were compared between the two groups...
The Separate and Combined Effects of Insulin, Dexamethasone and Growth Hormone on the OB Gene Expression and Leptin Secretion from Cultured Human Visceral Adipose Tissue
Il Tae Hwang, Kyung Hee Kim, Jin Soon Hwang, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2003;46(8):795-802.   Published online August 15, 2003
Purpose : We investigated the hormonal control of OB gene expression and leptin secretion in cultured human visceral adipose tissue. Methods : Visceral adipose tissues were cultured for up to 48 hrs in modified Eagle's medium with varying concentration of hormones : Control(no hormone), bovine insulin(100 nM), Dexamethasone(DEX, 100 nM), growth hormone(GH, 40 ng/mL), insulin+DEX(100 nM each), insulin+DEX+GH(100 nM insulin...
The Changes of Biochemical Bone Markers in Pediatric Epileptic Children Who Received Long-term Antiepileptic Drugs and Usefullness Thereof
Eun Kyung Choi, Kyung Hee Kim, Sun Jun Kim
Clin Exp Pediatr. 2001;44(7):778-785.   Published online July 15, 2001
Purpose : Long-term administration of anticonvulsants for pediatric epileptic patients may cause changes of bone metabolism. This study was performed to evaluate the influence of antiepileptics on the bone metabolism and growth in pediatric patients who received antiepileptics. Methods for early detection of adverse bone metabolism were also evaluated. Methods : Forty-eight epileptic patients were enrolled in this study....
The Changes of Apoptosis and Viability in Stem Cells after Thawing with Lapse of the Time
Seun Joo Park, Sang Young Bae, Kyung Ha Ryu, Il Tae Whang, Kyung Hyo Kim, Young Mi Hong, Kyung Hee Kim, Keun Lee, Joo Young Seoh
Clin Exp Pediatr. 2000;43(12):1576-1582.   Published online December 15, 2000
Purpose : Thawed stem cells should be infused as early as possible because delay of infusion leads to decrease of cell viability and formation of DNA clumping. The procedure of 10% Dimethyl sulfoxide(DMSO) removal and a long distance from the thawing location to the patient are the main causes of delay of infusion that results in the loss of cell...
Case Report
A Case of Multicystic Encephalomalacia in a Liveborn Twin with a Stillborn Co-twin
Mi Ya Park, Kyung Hee Kim, Jae Seung Yang, Baek Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 1997;40(3):429-433.   Published online March 15, 1997
Multicystic encephalomalacia is the condition defined anatomically by the presence of multiple cavities in the great part of both cerebral hemispheres. The most common cause of the condition was regarded as the circulatory disturbance during the perinatal period. Also,neonatal asphyxia was the most important cause of the circulatory disturbance. But we experienced a case of multicystic encephalomalacia in a liveborn twin with a stillborn...
Original Article
Varicella Zoster Virus Spicific IgG Antibody Titer in Vaccinated and Infected Children
Young Eun Lee, Eun Ae Park, Kyung hee Kim
Clin Exp Pediatr. 1996;39(7):934-942.   Published online July 15, 1996
Purpose : Varicella is mild self limited disease with vesicular skin eruption but highly contagious and accompanied many complications. Especially, varicella is fatal in leukemic children and immunocompromised children. The live varicella zoster virus was first developed by Takahashi et al. in the 1974. This vaccine has now been licensed for general use in Europe and the United States as well as in Korea.. The...
Case Report
A Case of Cystic Pancreatoblastoma Associated with Congenital Hemihypertrophy
Hyun Joo Lee, Kyuong Ha Yoo, Young Mi Hong, Kyung hee Kim, Kum Ja Choi, Joung Hyun Yoo, Sung Sook Kim
Clin Exp Pediatr. 1996;39(6):861-865.   Published online June 15, 1996
We experenced a case of cystic pancreatoblastoma associated with congenital hemihypertrophy in a 4months old male. The mass was located on the anterior side of pancreatic head without any connection to the pancreas. After exision of cystic pancreatoblastoma, chemotherapy(FAM regimen) was performed 15 times due to capsular tumor invasion. Until this time there was no drug side effect and metastasis....
Original Article
Changes of Cerebral Blood Flow Velocity before and after Closure of Ductus Arteriosus using Doppler Ultrasound in Normal Full-term Newborns
Myung Su Lee, Young Mi Hong, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(12):1620-1628.   Published online December 15, 1995
Purpose : With PDA, major fluctuations of blood flow are noted between opening and closure of ductus arteriosus and there is an increase in the amplitude of each pulse of blood flow. The purpose of this study was to evaluate the changes of cerebral blood flow before and after closure of ductus arteriosus in healthy term newborns. Methods : Forty-two normal term...
Auditory Brainstem Responses in Premature and Fullterm Infants
Hyun Mi Kim, Tae Sung Ko, Ki Soo Kim, Moo Song Lee, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(8):1036-1045.   Published online August 15, 1995
Purpose : We tried to know normal range of auditory brainstem responses in premature and fullterm infants who have no rksk factor during perinatal period and to determine that the abnormal ABR in premature and fullterm infants may predict developmental delay. Methods : ABR evaluations were performed on 283 premature and fullterm infants from NICU of the Asan Medical Center during...
Diagnostic Value of Stable Microbubble Rating test and Efficacy of Surfactant Replacement Therapy in Neonates with Respiratory Distres syndroems
Jeong Hee Kim, Eun Ae Park, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(6):760-770.   Published online June 15, 1995
Purpose : Stable microbubble rating test(SMR) plays an important role in the clinical course and the prognosis of respiratory distress syndrome(RDS) patients, because SMR can be easily performed and it can predict quickly the neonatal RDS. After the success of the pulmonary surfactant replacement therapy in RDS infants by Fujiwara and co-workers in 1980, many supporting studies were presented and...
Case Report
A Case of Glycogen Storage Disease Type Ⅰb
Ji Young Rhou, Eun Yae Park, Kyung Hee Kim, Su Yeun Jo, Hye Su Koo
Clin Exp Pediatr. 1995;38(4):545-551.   Published online April 15, 1995
Glycogen storage disease(GSD) type Ⅰis due to defect of glycose-6-phosphatase at the membrane of the endoplasmic reticulum in liver. Clinical presentations of GSD 1 are massive hepatomegaly without splenomegaly, failure to thrive, bleeding tendency, hypoglycemia, fasting ketosis and hyperlipidemia. The appearance of patient is short and fat with particularly fat cheeks. Mental development is usually normal. It was diagnosed by...
Original Article
Varicella-zoster Antibody Titer in Neonates according to Gestational Age
Ji Young Rhou, Eun Yae Park, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(3):311-318.   Published online March 15, 1995
Purpose : Acquisition of varicella by the neonate as a result of congenital varicella-zoster infection or exposure during delivery is well known. And it generaly believed that infants under 6 months of age may acquire varicella more frequently than other viral infections such as measles. However, little if known about immune mechanism of varicella-zoster infection. Transfer maternal antibodies to this...
Airway Resistance after Exercise Loading Test in Asthmatic Children
Ji Eun Lee, Young Mi Hong, Kyung Hee Kim
Clin Exp Pediatr. 1994;37(10):1333-1339.   Published online October 15, 1994
Exercise induced asthma(EIA) is defined as acute, reversible, usually self-immiting airway obstruction which develop after strenous exercise in patients with asthma. EIA is a bigger problem in children than adults due to more active and smaller airways which obstruct more easily when bronchospasm develops. The exercise elicited amny change in pulmonary function of asthmatic children. These change could be measured...
Case Report
A Case of Congenital T Cell Lymphoblastic Lymphoma
Eun Sun Yoo, Young Mi Hong, Kyung Hee Kim, Hae Soo Gyu, Eun Chul Chung
Clin Exp Pediatr. 1994;37(9):1296-1304.   Published online September 15, 1994
T cell lymphoblastic lymphoma is characterized by immature lymphoid cells that are indistinguishable from the lymphoblasts and prolymphocytes of acute lymphoblastic leukemia. Several characteristic clinical features of lymphoblastic lymphoma, with include a high male-to-female ratio, a relatively high incidence in older children and young adults, the frequent presence of mediastinal involvement at the time of diagnosis. Also, this disease is...
Original Article
A Study on Serum Immunoglobulins and Complements in Newborn Infants by Gestational Weeks
Ji Eun Lee, Kyung Hyo Kim, Kyung Hee Kim
Clin Exp Pediatr. 1993;36(11):1555-1561.   Published online November 15, 1993
The author investigated serum immunoglobulin (IgG, IgA, and IgM) and complements (C3) of cord blood in 74 cases of normal fulterm infants and 50 cases of premature infants. Serum immunolglobulin and complement levels were measured by the single radial immunodiffusion method. The following results were obtained ; 1) The mean serum IgG levels of cord blood in 74 cases of the normal...
Anemia due to Prolonged Breast Feeding without Weaning Diet or Supplement Food
Kyung Hee Kim, Kun Rae Lee, Hyun Lee, Yoon Suck Suh, Baek Lin Eun
Clin Exp Pediatr. 1993;36(4):528-536.   Published online April 15, 1993
The paramount importance of breast feeding for the health of the infants has been recognized by nutritionists and physicians. Although many advantages of the breast feeding, exclusive breast feeding without weaning diet or supplement food during prolonged period in infants may produce iron deficiency anemia. This study was conducted to find out the hematologic state in exclusively prolonged breast-fed infants among...
Follow up Study of Urinary Tract Infection Associated with Vesicoureteral Reflux
Kyung Hee Kim, Young Jin Hong, Soon Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1992;35(12):1713-1721.   Published online December 15, 1992
The authors studied 25 cases with urinary tract infection associated with vesicoureteral reflux who were admitted to department of pediatrics, National Medical Center. The patients were managed medically or surgically and followed up. The results were summarized as follows; 1) There were no difference in age and sex distributions of the 25 cases with vesicoureteral reflux. 2) The degree of reflux classified by International...
Case Report
A Case of Agenesis of the Right Lung with H-type Tracheoesophageal Fistula
Yong Seok Choi, Kyung Hee Kim, Young Chul Ahn, Baik Lin Eun, Kwang Je Beck
Clin Exp Pediatr. 1992;35(6):816-821.   Published online June 15, 1992
Agenesis of the lung is a developmental defect with complete absence or profound hypoplasia of one or both lung : absence of one lung is more common. Absence of both lung is very rare and is incompatible with life. Unilateral or bilateral agenesis of the lung often associated with the skeletal, cardiovascular, gastrointestinal and genitourinary anomalies. H-type tracheoesophageal fistula in...
Original Article
Clinical Observation on Reye syndrome According to the Onset of Age in Children
Kyung Hee Kim, Baik Hee Lee, Myung Ik Lee, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1992;35(6):788-794.   Published online June 15, 1992
A clinical observation according to the age of onset was made on 40 children with Reye syndrome who had been admitted to pediatric department of National Medical Center during 11 year period from January 1979 to December 1989. 1) Annual distribution showed the largest number in 1982. There was no significant difference in seasonal distribution. 2) Cases of infant comprised 22 (55.0%)...
A measurement of measles antibody titer in pediatric age group.
Min Hyea Kim, Jee Eun Lee, Jung Weon Seo, Young Mee Hong, Kyung Hee Kim
Clin Exp Pediatr. 1991;34(11):1519-1525.   Published online November 30, 1991
We measured the degree of immunity of 155 childrens with the age from birth to 12 years to measles antibody titer by enzyme-linked immunosorbent assay (ELIZA) for determine the proper age the Measles vaccination. The results were as follows; 1) By age group, 64% of the children was positive for Measles IgG antibody with the age between 1 and 2 months and 17% of the children with...
Prevalence of hepatitis B surface antigen in pediatric in patients.
Kyung Hee Kim, Myung Ik Lee, Young Jin Hong, Keun Chan Sohn
Clin Exp Pediatr. 1991;34(3):355-362.   Published online March 31, 1991
Thirty three from 689 children (4.79%) who were screened among hospitalized patients from July, 1986 to June, 1988, were positive for hepatitis B surface antigen in their serum sample tested by radioimmunoassay. The positive rate of hepatitis B surface antigen was 3.04% when the hepatitis patients were excluded. The incidence of hepatitis B surface antigen was higher (5.18%) in male than in famale (4.17%)...
The Apgar Score and Umbilical Arterial pH in the Newborn.
Hoo Jae Hann, Eun Ae Park, Kyung Hee Kim
Clin Exp Pediatr. 1990;33(8):1048-1056.   Published online August 31, 1990
In this prospective study, the relation between the Apgar scores and umbilical arterial pH at birth was assessed. 314 newborns of gestational age 24 to 42 weeks were included in this study; (95 were preterm and 219 were full-term) The l and 5-minute Apgar scores were directly related to gestational age. In preterm babies, the Apgar scores tend to be low in spite...
Pulmonary Air Leaks in the Newborn.
Soon Wha Kim, Kyung Hee Kim, Young Jin Hong, Don Hee Ahn
Clin Exp Pediatr. 1990;33(7):907-914.   Published online July 31, 1990
A clinical study was performed on 26 cases of pulmonary air leaks in the newborn who were admitted to the NICU of National Medical Center from Jan. 1984 to Aug. 1988 The results were as follows: 1) Spontaneous air leaks were 2 cases (7.7%)and secondary air leaks were 24 cases (92.3%). 2) Of the 26 cases of pulmonary air leaks, 13 cases (50.0%) had meconium aspiration...
Clinical Studies on Congenital Anomalies.
Hyeon Joo Chai, Kyung Hee Kim
Clin Exp Pediatr. 1990;33(6):754-761.   Published online June 30, 1990
Modem medical science has been developed advanced rapidly in the past years, but congenital anomalies are known as a major cause of neonatal death. So, we studied the incidence of congenital malformations among 11,119 babies deliveried or admitted at EWUH during a period of five years starting from June 1983. The results were as follows: 1) The incidence of congenital malformations among 11,119 deliveries was 1.5%(1.5%...
A Case of Transient Myeloproliferative Disorder in Down's Syndrome.
Ji Hye Kang, Young Mi Hong, Kyung Hee Kim, Seung Joo Lee, Ki Sook Hong, Ok Kyung Kim, Je Geun Chi
Clin Exp Pediatr. 1990;33(2):252-258.   Published online February 28, 1990
Transient myeloproliferative disorder has been reported in infant with Down's syndrome during neonatal period. This is clinically and hematologically indistinguishable from congenital acute leukemia. In contrast to congenital leukemia, complete clinical and hematological recovery occurs within weeks to months of diagnosis without antileukemic treatment. A neonate presented with jaundice, hepatosplenomegaly and mongoloid face was diagnosed as Transient myeloproliferative disorder. We report this case with a review of...
Factors Associated with Pneumothorax in Hyaline Membrane Disease In fants Receiving Mechanical Ventilation.
Oh Kyung Lee, Kyung Hee Kim, Kyu Sun Choi, Wan Seoub Kim
Clin Exp Pediatr. 1989;32(12):1642-1649.   Published online December 31, 1989
We observed 42 cases of neonates, who were diagnosed as having Hyaline membrane disease and had been received mechanical ventilation in neonatal intensive care unit of Presbyterian medical center from July 1984 to July 1988. In order to observe the factors associated with pneumothorax, we devide these cases in two groups. First group was consists of infants with pneumothorax, second group was consists of...
A case of Dandy-Walker syndrome.
Kyung Hee Kim, Jong Leam Choi, Hyo Sook Hong, Wan Seop Kim
Clin Exp Pediatr. 1989;32(11):1586-1591.   Published online November 30, 1989
Dandy-Walker syndrome is a developmental disorder of the brain associated with hydrocephalus, possterior fossa cyst and maldevelopment of the cerebellar vermis and is a result of outlet obstruction of the fourth ventricle. We experienced a case of a 6 day old male neonate who presented macrocephaly which revealed marked dilated fourth & lateral ventricle, large posterior fossa cyst and hypoplastic cerebellum, no vermis on Brain...
A Case of Cockayne Syndrome.
Jong Leam Choi, Kyung Hee Kim, Hyo Sook Hong, Wan Soeb Kim
Clin Exp Pediatr. 1989;32(10):1422-1427.   Published online October 31, 1989
We experienced a case of Cockayne syndrome in a 12 10/12 year-old male who had characteristic manifestations with cachectic dwarfism, severe mental retardation, intracranial calcifications, an unusal face, photo-sensitive dermatitis and joint flexion contractures. Laboratory investigations have not revealed any consistent abnormality. We report this case with brief review of some related literatures.
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