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Original Article
Serum Vascular Endothelial Growth Factor as a Predictive Risk Factor for the Occurrence of Coronary Artery Lesions in Kawasaki Disease
Min Hyuk Park, Hye Lim Jung, Ju Hee Yang, Jung-Yeon Shim, Deok Soo Kim, Jae Won Shim, Moon Soo Park
Clin Exp Pediatr. 2003;46(8):811-816.   Published online August 15, 2003
Purpose : Kawasaki disease is an acute systemic vasculitis of unknown etiology with a predilection for the coronary arteries. Vascular endothelial growth factor(VEGF) is a cytokine which promotes vascular permeability and angiogenesis. We investigated serum VEGF(sVEGF) levels in Kawasaki disease to determine whether sVEGF level can be used as a risk factor to predict the occurrence of coronary artery lesions(CAL)...
Increased Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Levels in the Cerebrospinal Fluid from Children with Aseptic Meningitis
Ju Hee Yang, Min Hyuk Park, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuck Keum
Clin Exp Pediatr. 2003;46(6):548-553.   Published online June 15, 2003
Purpose : Matrix metalloproteinase(MMP)-9 is known to breakdown the blood-brain barrier by degrading the extracellular matrix of the subendothelial basement membrane in meningitis. Tissue inhibitor of metalloproteinase(TIMP)-1, a known inhibitor of MMP-9, has been postulated to inhibit the proteolytic activity of MMP-9 by bindng to MMP-9, but their interaction has not been fully understood yet. So far, there have been...
Case Report
Two Cases of Gitelman's Syndrome Diagnosed by Renal Clearance Study
Tae Hwa Kim, Seung Jun Kim, Yu Kyung Seo, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuk Kum
Clin Exp Pediatr. 2002;45(3):413-417.   Published online March 15, 2002
Gitelman's syndrome is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria that has recently been reported to be linked to thiazide-sensitive Na-Cl cotransporter gene mutation. In this study, we performed renal clearance studies to differentiate Gitelman's from Bartter's syndrome and to confirm the diagnosis in two patients clinically diagnosed with Gitelman's syndrome. Each patient was hydrated...
Original Article
Changes of Interleukin-10 and Granulocyte Colony-Stimulating Factor in Cerebrospinal Fluid of Children with Aseptic Meningitis
Byeong Chan Park, Jung-Yeon Shim, Jeong Mi Lee, Jin-Young Park, Myung Ja Yoon, Hye Rim Jung, Moon Soo Park, Dong Hyeuk Keum, Dong Keug Keum
Clin Exp Pediatr. 1999;42(12):1676-1682.   Published online December 15, 1999
Purpose : Interleukin(IL)-10 is an antiinflammatory cytokine produced by monocytes/macrophages. Granulocyte colony-stimulating factor(G-CSF) plays an important role, not only as a hemopoietic factor but also as a regulating factor for a biologic defense system by neutrophils, in the foci of infection. We studied G-CSF and IL-10 levels in the serum and cerebrospinal fluid(CSF) of patients with aseptic meningitis and investigated...
Clinical and MRI Findings of Acute Disseminated Encephalomyelitis Associated with Preceding Infections Confirmed Serologically
Jung-Yeon Shim, Tae-Sung Ko, Hyung-Nam Moon, Chang-Yee Hong, Choong-Gon Choi,, Shi-Joon Yoo, Dae-Chul Suh
Clin Exp Pediatr. 1998;41(4):505-513.   Published online April 15, 1998
Purpose : Acute disseminated encephalomyelitis(ADEM) is an inflammatory demyelinating disease of the central nervous system. The pathogenesis is not well known, but it is thought to be an immune-mediated disease and may follow a viral infection or vaccinations. MRI demonstrates decreased signal on T1 weighting and increased signal on T2-weighted image. We report clinical features and characteristic MRI findings in seven patients with ADEM...
Molecular Genetic Screening for the SRY(Sex Determining Region of the Y chromosme) Gene in Turner Syndrome Patients
Jung-Yeon Shim, Han-Wook Yoo
Clin Exp Pediatr. 1996;39(7):915-923.   Published online July 15, 1996
Purpose : Turner syndrome is among the most common cytogenetic abnormalities associated with X chromosome. In only 40-60% of Turner syndrome, 45,X monosomy is found and the high prenatal mortality of non-mosaic 45,X has led to the hypothesis that liveborn 45,X individuals may be cryptic mosaics. The presence of Y chromosome is significant because it predisposes affected individuals with Turner syndrome to gonadoblastoma formation....
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