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Original Article
Infection
Usefulness of the procalcitonin test in young febrile infants between 1 and 3 months of age
In Sul Lee, Young Jin Park, Mi Hyeon Jin, Ji Young Park, Hae Jeong Lee, Sung Hoon Kim, Ju Suk Lee, Cheol Hong Kim, Young Don Kim, Jun Hwa Lee
Clin Exp Pediatr. 2018;61(9):285-290.   Published online September 15, 2018

Purpose: To study the usefulness of the procalcitonin (PCT) test in young febrile infants between 1 and 3 months of age. Methods: We evaluated the medical records of 336 febrile infants between 1 and 3 months of age who visited the Emergency Department or outpatient department of Samsung Changwon Hospital from May 2015 to February 2017, and analyzed the clinical characteristics...
Case Report
Neurology
A young child of anti-NMDA receptor encephalitis presenting with epilepsia partialis continua: the first pediatric case in Korea
Eun-Hee Kim, Yeo Jin Kim, Tae-Sung Ko, Mi-Sun Yum, Jun Hwa Lee
Clin Exp Pediatr. 2016;59(Suppl 1):S133-S138.   Published online November 30, 2016

Anti-N-methyl D-aspartate receptor (anti-NMDAR) encephalitis, recently recognized as a form of paraneoplastic encephalitis, is characterized by a prodromal phase of unspecific illness with fever that resembles a viral disease. The prodromal phase is followed by seizures, disturbed consciousness, psychiatric features, prominent abnormal movements, and autonomic imbalance. Here, we report a case of anti-NMDAR encephalitis with initial symptoms of epilepsia partialis...

Genetics and Metabolism
Maternal 3-methylcrotonyl-coenzyme A carboxylase deficiency with elevated 3-hydroxyisovalerylcarnitine in breast milk
Kyung Lae Cho, Yeo Jin Kim, Song Hyun Yang, Gu-Hwan Kim, Jun Hwa Lee
Clin Exp Pediatr. 2016;59(Suppl 1):S41-S44.   Published online November 30, 2016

We report here a case of maternal 3-methylcrotonyl-coenzyme A carboxylase (3-MCC) deficiency in a Korean woman. Her 2 infants had elevated 3-hydroxyisovalerylcarnitine (C5-OH) on a neonatal screening test by liquid chromatography-tandem mass spectrometry (LC-MS/MS), but normal results were found on urine organic acid analysis. The patient was subjected to serial testing and we confirmed a maternal 3-MCC deficiency by blood...

Long-term clinical course of a patient with mucopolysaccharidosis type IIIB
Ja Hye Kim, Yang Hyun Chi, Gu-Hwan Kim, Han-Wook Yoo, Jun Hwa Lee
Clin Exp Pediatr. 2016;59(Suppl 1):S37-S40.   Published online November 30, 2016

Mucopolysaccharidosis type III (MPS III) is a rare genetic disorder caused by lysosomal storage of heparan sulfate. MPS IIIB results from a deficiency in the enzyme alpha-N-acetyl-D-glucosaminidase (NAGLU). Affected patients begin showing behavioral changes, progressive profound mental retardation, and severe disability from the age of 2 to 6 years. We report a patient with MPS IIIB with a long-term follow-up...

A case of idiopathic isolated hypoglossal nerve palsy in a Korean child
Ji Hoi Yoon, Kyung Lae Cho, Hae Jung Lee, Seo Hui Choi, Kyung Yul Lee, Sung Koo Kim, Jun Hwa Lee
Clin Exp Pediatr. 2011;54(12):515-517.   Published online December 31, 2011

Hypoglossal nerve palsy (HNP) is an uncommon neurological abnormality that can provoke characteristic clinical signs, including unilateral atrophy of the tongue musculature. We present the case of a healthy 11-year-old Korean male who was admitted to the outpatient department of our institution with acute onset dysarthria, tongue fasciculations, and right-sided tongue weakness upon awakening. His evaluation included a virology work-up,...

Original Article
A study on the therapeutic effects of Topiramate according to the types of migraine
Jun Hwa Lee, Kyung Lae Cho
Clin Exp Pediatr. 2010;53(4):554-559.   Published online April 15, 2010
Purpose : The purpose of this study was to evaluate whether the therapeutic effects of topiramate differ according to the types of migraine. Methods : We recruited 38 children and adolescents with migraine who had been treated with topiramate. The effect of topiramate was evaluated on the basis of the change in the frequency of migraine attacks after treatment. Results : Among...
Clinical analysis of pediatric patients who visited Masan Samsung Emergency Center
Jae Wook Yoo, Jun Hwa Lee
Clin Exp Pediatr. 2010;53(3):314-322.   Published online March 15, 2010
Purpose : Through a clinical and retrospective analysis of pediatric patients who visited the Regional Emergency Medical Center of Masan Samsung Hospital from January 2007 to December 2008, we characterized pediatric and adolescent emergency patients to improve emergency care in future. Methods : We reviewed the medical records of 14,065 pediatric patients below 19 years of age. Results : The...
Case Report
A Korean familial case of hereditary complement 7 deficiency
Moon Kyu Ki, Kyung Yul Lee, Jun Hwa Lee
Clin Exp Pediatr. 2009;52(6):721-724.   Published online June 15, 2009
Meningococcal infections can be associated with abnormalities of the complement system, which contains 5 terminal complement proteins. Furthermore, deficiencies in 1 of these 5, complement component 7 (C7), leads to the loss of complement lytic function, and affected patients show increased susceptibility to recurrent meningococcal meningitis and systemic Neisseria gonorrhoeae infection. In September 2003, an 11-year-old female patient presented at...
Original Article
Assessment of parental understanding of epilepsy and effects of educational programs in an epilepsy camp
Sung Min Cho, Soon Hak Kwon, Doo Kwun Kim, Jun Sik Kim, Han Koo Moon, Hye-Eun Se, Kye Hyang Lee, Eun Ju Lee, Jun Hwa Lee, Nho Eun Kim
Clin Exp Pediatr. 2009;52(5):549-556.   Published online May 15, 2009
Purpose : To assess parental knowledge and understanding of epilepsy including social stigma and evaluate the effects of educational programs on parents in an epilepsy camp. Methods : We conducted an epilepsy camp on August 23-24, 2008, at Gyeongsan. Twenty families with an epileptic child each participated in the camp. We performed a survey before and after the camp to...
Case Report
A case of fatal pneumococcal 19A meningoencephalitis despite administration of seven-valent pneumococcal conjugate vaccines
Ah Rum Heo, Jun Hwa Lee
Clin Exp Pediatr. 2009;52(4):508-511.   Published online April 15, 2009
Streptococcus pneumoniae is a major cause of serious invasive diseases in children, especially in young infants, but seven- valent pneumococcal conjugate vaccine (PCV7) is believed to prevent invasive pneumococcal pneumonia and meningitis in young children. However, recently, the incidence of non-PCV7 serotype has increased after PCV7 vaccination. A 14-month- old female patient presented at our emergency room with mental change...
Original Article
Neuroprotective effects of resveratrol via anti-apoptosis on hypoxic-ischemic brain injury in neonatal rats
Jin Young Shin, Min Ae Seo, Eun Jin Choi, Jin Kyung Kim, Eok Su Seo, Jun Hwa Lee, Hai Lee Chung, Woo Taek Kim
Clin Exp Pediatr. 2008;51(10):1102-1111.   Published online October 15, 2008
Purpose : Resveratrol, extracted from red wine and grapes, has an anti-cancer effect, an antiinflammatory effect, and an antioxidative effect mainly in heart disease and also has neuroprotective effects in the adult animal model. No studies for neuroprotective effects during the neonatal periods have been reported. Therefore, we studied the neuroprotective effect of resveratrol on hypoxic-ischemic brain damage in neonatal...
Clinical review of acute seizures among children who visited the emergency room in Masan Samsung hospital from 2004 to 2006
Won Deok Lee, Jae Wook Yoo, Ju Suk Lee, Jun Hwa Lee, Kyung Lae Cho
Clin Exp Pediatr. 2008;51(4):420-425.   Published online April 15, 2008
Purpose : The purpose of this study was to evaluate acute childhood seizures, one of the most important causes of emergency room visits, to provide appropriate medical services. Methods : We reviewed the medical records of 433 (4.6%) pediatric patients with acute seizures that visited the emergency room at Masan Samsung hospital from 2004 to 2006. Results : The male to...
Case Report
A familial case report of paroxysmal kinesigenic dyskinesia in three brothers
Oh Dae Kwon, Sung Jin Hwang, Jun Hwa Lee, Ji Eun Kim, Kyung Jib Kim, Eul Ju Seo
Clin Exp Pediatr. 2007;50(7):694-697.   Published online July 15, 2007
Paroxysmal kinesigenic dyskinesia (PKD), previously referred to as movement-provoked seizures, is a rare neurological condition that is characterized by short duration dystonic or choreoathetotic movements precipitated by sudden movement, a change in position or hyperventilation. It can be difficult to distinguish this syndrome from seizures. We reported on three brothers in one family all of whom developed abnormal involuntary dystonic...
A case of childhood relapsing/remitting multiple sclerosis and interferon β-1b treatment in a Korean patient
Hyun Seok Kim, Won Deok Lee, Jun Hwa Lee, Kyung Lae Cho
Clin Exp Pediatr. 2007;50(6):580-584.   Published online June 15, 2007
Multiple sclerosis (MS) is a demyelinating disorder that affects discrete areas of the CNS, including the optic nerves, in a quite variable relapsing-remitting fashion over a prolonged period of time. Although MS is usually considered to be a disease that affects peoples in early to middle adulthood, children do develop multiple sclerosis. The frequency of MS onset before the age...
A case of Dyke-Davidoff-Masson syndrome in Korea
Jun Hwa Lee, Zee Ihn Lee, Ho Kyun Kim, Soon Hak Kwon
Clin Exp Pediatr. 2006;49(2):208-211.   Published online February 15, 2006
Dyke-Davidoff-Masson Syndrome (DDMS) is a rare condition characterized by asymmetry of cerebral hemispheric growth with atrophy on one side, ipsilateral compensatory osseous hypertrophy, and contralateral hemiparesis. We experienced a 17 month-old male who presented with left focal clonic or tonic-clonic seizures accompanied by left hemiparesis and developmental delay. Brain MRIs demonstrated progressive atrophy of the right cerebral hemisphere with dilatation...
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