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Original Article
Nephrology (Genitourinary)
Is vaginal reflux associated with urinary tract infection in female children under the age of 36 months?
Yu Bin Kim, Chih Lung Tang, Ja Wook Koo
Clin Exp Pediatr. 2018;61(1):17-23.   Published online January 22, 2018

To determine the relationship between vaginal reflux (VR) and urinary tract infection (UTI) in female children aged <36 months.


A single center retrospective study was performed for 191 girls aged <36 months, with a diagnosis of febrile UTI, who underwent a voiding cystourethrography (VCUG) for assessment of vesicoureteral reflux (VUR) at Sanggye Paik Hospital. Fifty-one girls, who underwent VCUG for assessment...

Intravenous fluid prescription practices among pediatric residents in Korea
Jiwon M. Lee, Younghwa Jung, Se Eun Lee, Jun Ho Lee, Kee Hyuck Kim, Ja Wook Koo, Young Seo Park, Hae Il Cheong, Il-Soo Ha, Yong Choi, Hee Gyung Kang
Clin Exp Pediatr. 2013;56(7):282-285.   Published online July 19, 2013

Recent studies have established the association between hypotonic fluids administration and hospital-acquired hyponatremia in children. The present paper investigated the pattern of current practice in intravenous fluid prescription among Korean pediatric residents, to underscore the need for updated education.


A survey-based analysis was carried out. Pediatric residents at six university hospitals in Korea completed a survey consisting of four questions. Each...

ERRATUM: Is routine screening examination necessary for detecting thromboembolism in childhood nephrotic syndrome?
Mun Sub Kim, Ja Wook Koo, Soung Hee Kim
Clin Exp Pediatr. 2008;51(8):897.   Published online August 15, 2008
Original Article
Is routine screening examination necessary for detecting thromboembolism in childhood nephrotic syndrome?
Mun Sub Kim, Ja Wook Koo, Soung Hee Kim
Clin Exp Pediatr. 2008;51(7):736-741.   Published online July 15, 2008
Purpose : The incidence of thromboembolic episodes in children with nephrotic syndrome (NS) is low; however, these episodes are often severe. Moreover, both pulmonary thromboembolism (PTE) and renal vein thrombosis (RVT) rarely show clinical symptoms. This study was performed to determine the benefits of routine screening in the detection of thrombosis in childhood NS. Methods : Among 62 children with...
Necessity of 99mTc-dimercaptosuccinic acid scan in infants with low grade vesicoureteral feflux
Ji Yeon Koh, Ja Wook Koo
Clin Exp Pediatr. 2006;49(6):648-652.   Published online June 15, 2006
Objective : 99mTc-dimercaptosuccinic acid(DMSA) scan is considered to be the most sensitive examination for detection of renal scars. However, because of its high radiation exposure to the kidney and its limited usefulness for patients with low grade vesicoureteral reflux(VUR), some authors have suggested that DMSA scans should be reserved primarily for children with VUR grade 3 and above. The aim...
Case Report
Steroid and enalapril therapy - possible cause of toxic epidermal necrolysis
Dong Wook Kim, Da Eun Jung, Ja Wook Koo
Clin Exp Pediatr. 2006;49(3):332-336.   Published online March 15, 2006
Toxic epidermal necrolysis (TEN) is a rare, acute and life-threatening cutaneous drug reaction. TEN is characterized by the sudden onset of extensive necrosis in the epidermis and frequent mucous membrane involvement. The pathogenesis has not yet been elucidated. In addition, no particular treatment for TEN has been established. We report a case of TEN in a 14-year-old-boy, which might have...
A case of a child with non-parasitic chyluria
Da Eun Jung, Ja Wook Koo, Sang Woo Kim, Hae Il Cheong
Clin Exp Pediatr. 2006;49(3):326-328.   Published online March 15, 2006
Chyluria is the passage of milky urine due to the leakage of lymph into the urinary tract. Chyluria occurs predominantly in adults and is rare in children. We present an unusual case in which a child with proteinuria, hematuria and milky urine was subsequently diagnosed with non-parasitic chyluria. Retrograde cystogram confirmed a lymphatico-calyceal communication. This case showed spontaneous remission. The...
Original Article
Usefulness of serum procalcitonin test for the diagnosis of upper urinary tract infection in children
Dong Wook Kim, Ju Young Chung, Ja Wook Koo, Sang Woo Kim, Tae Hee Han
Clin Exp Pediatr. 2006;49(1):87-92.   Published online January 15, 2006
Purpose : It is difficult to make a distinction between lower urinary tract infection(UTI) and acute pyelonephritis(APN) during the acute phase of febrile UTI due to nonspecific clinical symptoms and laboratory findings, especially among young children. We measured the serum procalcitonin(PCT) in children with UTI to distinguish between acute pyelonephritis and lower UTI, and to determine the accuracy of PCT...
Case Report
A Case of Cat Scratch Disease Confirmed by Polymerase Chain Reaction for Bartonella henselae DNA
Ju-Young Chung, Ja Wook Koo, Sang Woo Kim, Young Sam Yoo, Tae Hee Han, Seong Jig Lim
Clin Exp Pediatr. 2005;48(7):789-792.   Published online July 15, 2005
We report a case of cat scratch disease (CSD) caused by Bartonella henselae in a 14-year-old boy who developed lymphadenopathy in the right cervical area, after a raising canine pet for 10 months. The cervical lymphadenopathy persisted for 14 days. Immunofluorescent antibody testing for B. henselae with the patient's serum was 1:64 positive. Polymerase chain reaction (PCR) analysis using the...
Clinical Lecture
Hematuria in Children
Ja Wook Koo
Clin Exp Pediatr. 2004;47(12):1255-1261.   Published online December 15, 2004
The detection of even microscopic amounts of blood in a child's urine, whether accompanied by symptoms or asymptomatic, alarms the patient, parents, and physician, and often prompts the performance of many laboratory studies. Hematuria is one of the most important signs of renal or bladder disease, but proteinuria is a more important diagnostic and prognostic finding, except in the case...
Case Report
Atypical Hemolytic Uremic Syndrome Associated with Streptococcus pneumoniae Infection
Hyun Sug Lee, Ja Wook Koo, Sang Woo Kim, Hyun Soon Lee
Clin Exp Pediatr. 2004;47(2):217-222.   Published online February 15, 2004
Hemolytic uremic syndrome is the most common cause of acute renal failure in childhood. Atypical hemolytic uremic syndrome which is not usually associated with prodromal symptoms has a higher mortality rate and more tendency to progress to chronic renal failure. Children younger than two years of age are a more susceptible to pneumococcal infection and can develop more serious disease....
Original Article
Urinary Excretion of Various Urinary Proteins in Children with Vesicoureteral Reflux
Da Eun Jung, Ja Wook Koo
Clin Exp Pediatr. 2003;46(10):977-982.   Published online October 15, 2003
Purpose : This study aimed to examine the excretion of various urinary proteins in children with a history of urinary tract infection(UTI), with or without vesicoureteral reflux(VUR) or reflux nephropathy, and to identify means of predicting the severity of VUR or the presence of reflux nephropathy as indicated by these markers, and to know how these markers are changed after...
Incidence of Vesicoureteral Reflux in Asymptomatic Siblings of Patients with Reflux
Jong Shik Kim, Ja Wook Koo
Clin Exp Pediatr. 2002;45(12):1540-1545.   Published online December 15, 2002
Purpose : Vesicoureteral reflux(VUR) is defined as a retrograde flow of urine from the bladder into the upper urinary tract. It has been shown to predispose patients to hypertension, renal scarring, and end-stage renal failure if not recognized and treated. The observation that VUR occurs in siblings of children with reflux at a significantly higher rate than the general pediatric...
Medical Lecture Course
Renal Interstitial Fibrosis and Renin Angiotensin System Inhibition
Ja Wook Koo
Clin Exp Pediatr. 2001;44(3):292-296.   Published online March 15, 2001
Case Report
A Case of Q Fever : Person-to-Person Transmission
So Jung An, Ja Wook Koo, Chul Young Chung, Won Young Lee
Clin Exp Pediatr. 1998;41(1):120-124.   Published online January 15, 1998
Q fever is an important zoonosis caused by the rickrttsial organism, Coxiella burnetii. It is a very contagious organism which humans can contact by inhaling aerosolized organisms. Most commonly it leads to an acute flu-like illness. The diagnosis is usually confirmed serologically using a complement fixation or microimmunofluorescence test. Previous reports suggest that case -to - case in men is rare. We report person-to-person...
A Case of Q Fever with Agranulocytosis
Seong Woo Choi, Ja Wook Koo, Heung Dong Kim, Churl Young Chung, Won Young Lee
Clin Exp Pediatr. 1995;38(6):848-852.   Published online June 15, 1995
A 9-year old boy suffered from fever 20 days. He lived in rural area near farms rearing cows, goats, sheep. He had fever for 20 days with mild respiratory symptom, hepatosplenomegaly and agranulocytosis. Coxiella burnetii infection was confirmed by the blood culture and demonstration of the specific antibodies in the indirect fluorescent antibody test. Four weeks later, agranulocytosis was improved...
Original Article
Yersinia pseudotuberculosis Infection Confirmed by Stool Culture in Children
Seung Nam Park, Kyeong Mi Jung, Ja Wook Koo, Churl Young Chung, Chong Rae Cho
Clin Exp Pediatr. 1995;38(2):189-194.   Published online February 15, 1995
Purpose : The clinical significance of Y. pseudotuberculosis infection has recently recognizd in various part of the world, because it can cause a wide range of clinical problems such as mesenteric lymphadenitis, septicemia, reactive arthritis, terminal ileitis, erythema nodosum, and a cute renal failure. We have experienced 19 children with Y. pseudotuberculosis infection confirmed by stool culture. Our aim in...
Serum Alkaline Phosphatase Activity after Intravenous Administration of Albumin Preparation
June Huh, Kang Mo Ahn, Ja Wook Koo, Il Soo Ha, Hae Il Cheong, Yong Choi
Clin Exp Pediatr. 1993;36(6):830-836.   Published online June 15, 1993
Serum alkaline phosphatase(AP) activity is elevated in hepatobiliary disease, bone disease, pregnancy and certain neoplasms. Recently we experienced marked elevation of serum AP activity after administration of ablumin preparation in nephrotic patients who suffered from hypovolemic symptoms. So serum AP activity and the isoenzymes in the albumin preparations & patient뭩 serum after the administration of albumin preparation were studied. Serum...
Production and characterization of monoclonal antibodies against human albumin.
Ja Wook Koo, Dong Kyu Jin, Yong Choi, Kwang Wook Ko, Suhnggwon Kim, Jung Sang Lee, Chung Gyu Park, Chang Yong Cha
Clin Exp Pediatr. 1991;34(8):1070-1079.   Published online August 31, 1991
Hybridoma technology를 이용하여 human albumin에 선택적으로 반응하는 4 종류의 단세포군 항 처 1(HSA-1,HSA-2, HSA-3, HSA-4) 를 개발하였다. 단세포군의 isotype 및 subclass를 효소 결합 면역 측정법으로 검색한 결과 IgGi 이었다. 단세포군 항체 HSA-1 을 제외한 HSA-2, HSA-3, HSA-4 모두 human albumin에 선택적으로 반 응함을 효소 결합면역 측정 법과 Western blot immunoassay로 알아내 었다. HSA-1, HSA-2, HSA-3는 albumin의 reduction 여부와 관계 없이 albumin molecule과 반응하였 으나,HSA-4는 albumin을 reduction하지...
A clinical study of continuous ambulatory peritoneal dialysis in childhood.
Tae Sun Ha, Hye Won Park, Ja Wook Koo, In Seok Lim, Hae Il Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1991;34(3):363-370.   Published online March 31, 1991
A retrospective analysis of clinical with findings in 24 children continuous ambulatory peritoneal dialysis (CAPD) who were admitted to the Department of Pediatrics, Seoul National University Children’s Hospital from March, 1987 till August, 1990 was performed and the results were as follows; 1) The male to female ratio was 16:8, and the age distribution at the beginning of CAPD was from 59 days to 16.5...
IgA Nephropathy in Childhood.
Yong Choi, Dong Woo Son, Ja Wook Koo, Dong Kyu Jin, Hae Il Cheong, Kwang Wook Ko, Hyun Soon Lee, Yong Il Kim
Clin Exp Pediatr. 1990;33(9):1237-1243.   Published online September 30, 1990
In this study we compared between the patients with recurrent gross hematuria (group 1, n=45) and * with nephrotic range proteinuria (group 2, n=21) in IgA nephropathy who were admitted to Seoul National University Children’s Hospital during the period from January, 1980 to December, 1989. The results of the study were as follows. 1) Age of onset and sex ratio were not different between the...
A Clinical Study on the Posterior Subcapsular Cataracts in Childhood Nephrotic Syndrome.
Dong Kyu Jin, Ja Wook Koo, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Jong Hoon Lee, Young Suk Yu
Clin Exp Pediatr. 1990;33(8):1097-1103.   Published online August 31, 1990
A clinical study was carried out in 73 children with nephrotic syndrome who had had regular ophthalmologic examination annually at Seoul National University Children’s Hospital from March 1976 to February 1990 with the aim of finding the relationship between the posterior subcapsular cataract (PSC) and the effect of corticosteroids. The results were summarized as follows: 1) The number of patients with PSC were 23 cases...
The Clinical Observation on Mucocutaneous Lymph Node Syndrome.
Sang Yun Ahn, Ja Wook Koo, Ha Baik Lee, Soo Jee Moon, Hahng Lee
Clin Exp Pediatr. 1990;33(2):196-204.   Published online February 28, 1990
The one-hundred-forty nine children with mucocutaneous lymph node syndrome who were diagnosed and treated through admission at the Department of Pediatrics, Hanyang University Hospital from July 1977 to January 1989, were investigated for clinical patterns and laboratory , correlations. The results are as follows: 1) Most patients (84.5%) were under 4 years of the age. 2) Boys were more prevalent than girls, as a ratio of 1.9:1. 3) Seasonal incidence...
A Case of Malignant Ependymoma.
Ja Wook Koo, Sun Ho Lee, In Joon Seol, Hahng Lee
Clin Exp Pediatr. 1989;32(1):130-136.   Published online January 31, 1989
Intracranial tumors presenting in the first year of life are uncommon. Brain tumors in infancy are predominantly supratentorial, whereas in older children the majority are infratentorial. Malignant ependymoma is a rare type of primitive ependymal tumor with clinically high malignancy. We experienced a malignant ependymoma in a 5 month old girl who had progressive enlargement of head circumference with vomiting. Brain computed tomography revealed...
Lateral Ventricular Indices in tuberculous Meningitis.
Ja Wook Koo, Hang Bo Cho, In Joon Seol, soo Jee Moon, Hahng Lee, Keun Soo Lee
Clin Exp Pediatr. 1988;31(8):984-991.   Published online August 31, 1988
Computed tomography is a very valuable method by which the pathogenic evolution of tuberculous meningitis may be followed, thereby facillitating its differential diagnosis and controlling the effi- ciency of therapy, and assessing the degree of hydrocephalus. Fifteen cases of clinically proven intracranial tuberculosis were studied by lateral ventricular indices of brain computed tomography in our hospital during last 3 years. The results were as follows: 1)...
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