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Case Report
A Case of Encephalopathy Presented with Motor Aphasia and Quadriplegia Following Intrathecal Methotrexate
Seon Woo Lee, Eun Hye Park, Hyun-Sang Cho, Jae Kook Cha, Hae Ran Lee
Clin Exp Pediatr. 2001;44(9):1066-1069.   Published online September 15, 2001
Intrathecal administration of methotrexate(IT-MTX) has constituted the standard approach to prophylaxis and treatment of central nevous system(CNS) leukemia. We experienced a quadriplegia and motor aphasia in a 14-year-old boy following repeated IT-MTX for the prophylaxis of meningeal leukemia. He was diagnosed as ALL without CNS involvement and treated by CCG- 1882 protocol. IT-MTX was administered for CNS prophylaxis. The patient began complaining of urinary incontinence,...
Original Article
Tumor Vaccine Effect by IL-16 Gene Transfer into Murine Neuroblastoma Model
Hyun-Sang Cho, Chong Young Park
Clin Exp Pediatr. 2001;44(1):68-74.   Published online January 15, 2001
Purpose : Interleukin(IL)-16 is a potent chemoattractant factor for CD4＋ T cells, monocytes, and eosinophils. It up-regulates IL-2R on CD4＋ T lymphocytes and regulates the function of antigen presenting cells. We used retrovirus-mediated gene transfer of the human IL-16 gene into the neuro-2a cells, which is the murine neuroblastoma cell lines, to investigate whether locally secreted IL-16 might generate anti-tumor...
Case Report
A Case of T-cell Acute Lymphoblastic Leukemia presented with Spontaneous Tumor Lysis Syndrome and Superior Vena Cava Syndrome
Eun Jung Shim, Hyun-Sang Cho, Jae Kook Cha, Jae Kook Cha, Chong Young Park
Clin Exp Pediatr. 2000;43(7):974-977.   Published online July 15, 2000
Acute spontaneous tumor lysis syndrome is a condition resulting from the rapid release of cellular breakdown products into the circulation due to massive cytolysis occurring before start of treatment. It occurs most often in Burkitt' s lymphoma and T-cell ALL, both of which have been well described, following cytotoxic chemotherpy and other single agent administrations. However, only a handful of spontaneous acute tumor lysis...
A Case of Inappropriate ADH Secretion Secondary to Vinblastine Therapy
Eun-Hye Park, Hyun-Sang Cho, Hae-Sook Yoo, Chuhl-Joo Lyu, Chang-Hyun Yang, Kir-Young Kim
Clin Exp Pediatr. 1998;41(10):1430-1432.   Published online October 15, 1998
Inappropriate secretion of antidiuretic hormone(ADH) secondary to vincristine therapy has been reported frequently. But there has been five previous reports of vinblastine associated SIADH in the world and in 4 reports, bleomycin and cis-platinum were used along with vinblastine together. Because penetration of vinka alkaloids into CSF of humans is known to be poor, it has been suggested that lowering...
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