Clinical and Experimental Pediatrics

Review Article

Infection

Updates on the coronavirus disease 2019 vaccine and consideration in children

Hyun Mi Kang, Eun Hwa Choi, Yae-Jean Kim

Clin Exp Pediatr. 2021;64(7):328-338. Published online June 21, 2021

· The number of coronavirus disease 2019 cases has exponentially increased worldwide, and children ≤19 years old account for 11.0% of all confirmed cases.
· mRNA vaccines, BNT162b2 and mRNA-1273, and adenoviral vector vaccines, AZD1222 and Ad26.COV2.S, authorized for emergency use in the Emergency Use Listing of the World Health Organization are reviewed.
· Clinical trials of these vaccines have shown that they are safe and serious adverse reactions are rarely observed.

DOI: https://doi.org/10.3345/cep.2021.00696

Effects of nasopharyngeal microbiota in respiratory infections and allergies

Hyun Mi Kang, Jin Han Kang

Clin Exp Pediatr. 2021;64(11):543-551. Published online April 15, 2021

Web of Science 7 Crossref 8

· The nasal microbiota varies with age and is shaped by various factors in healthy individuals.
· The pathological condition of the respiratory tract appears to be associated with reduced nasal microbiota biodiversity, while dysbiosis is involved in the pathophysiology of many respiratory diseases, including otitis, sinusitis, allergic diseases, and lower respiratory infections.

DOI: https://doi.org/10.3345/cep.2020.01452

Original Article

Infection

Febrile urinary tract infection in children: changes in epidemiology, etiology, and antibiotic resistance patterns over a decade

Woosuck Suh, Bi Na Kim, Hyun Mi Kang, Eun Ae Yang, Jung-Woo Rhim, Kyung-Yil Lee

Clin Exp Pediatr. 2021;64(6):293-300. Published online October 14, 2020

Web of Science 5 Crossref 6

Question: How has the antibiotic susceptibility of urinary pathogens changed and what does it imply?
Finding: A yearly increase in multidrug-resistant and extended-spectrum β-lactamase (ESBL)–producing pathogens was observed. A higher recurrence rate was observed in cases of febrile urinary tract infection caused by ESBL producers in patients with underlying vesicoureteral reflux (VUR).
Meaning: The initial empirical antibiotic should reflect the changing susceptibility patterns and underlying VUR status.

DOI: https://doi.org/10.3345/cep.2020.00773

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