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Review Article
Neonatal innate immunity and Toll-like receptor
Hye Sun Yoon
Clin Exp Pediatr. 2010;53(12):985-988.   Published online December 31, 2010

The innate immune response is the first line of defense against microbial infections. Innate immunity is made up of the surface barrier, cellular immunity and humoral immunity. In newborn, immunologic function and demands are different to adults. Neonatal innate immunity specifically suppresses Th1-type immune responses, and not Th2-type immune responses, which are enhanced. And the impaired response of macrophages is...

Case Report
A case of delayed hemorrhage of a subcapsular liver hematoma in a neonate
Soo Kyoung Moon, Tae Suk Lee, Hye Sun Yoon
Clin Exp Pediatr. 2008;51(1):89-92.   Published online January 15, 2008
A subcapsular liver hematoma (SLH) is a relatively common lesion in fetuses and neonates. Although an SLH ruptures rarely, it may be life threatening. We report on a term neonate with a delayed rupture of an SLH that occurred on day 7 of life. The infant had been resuscitated with intubation, positive pressure ventilation, and chest compression at birth because...
Original Article
Isolation rate of 4 type virus of acute gastroenteritis in full-term neonates during neonatal period
Soo Kyoung Moon, Jae In Lee, Hye Sun Yoon, Young Min Ahn
Clin Exp Pediatr. 2007;50(9):855-861.   Published online September 15, 2007
Purpose : The most common causes of acute viral gastroenteritis in newborn period are rotavirus, astrovirus, norovirus and enteric adenovirus. This study was designed to investigate the clinical characteristics, clinical symptoms, isolation rate and distribution of these viruses in full-term neonates during neonatal period. We also studied the influence on the viral isolation rate by postnatal care place and feeding...
Case Report
Two cases of Chryseobacterium meningosepticum infection in a neonatal intensive care unit
Hye Sun Yoon
Clin Exp Pediatr. 2007;50(7):698-701.   Published online July 15, 2007
We report on two premature infants who developed nosocomial infection caused by Chryseobacterium meningosepticum in a neonatal intensive care unit (NICU). One premature infant developed sepsis, meningitis, and hydrocephalus, and was treated successfully with ciprofloxacin plus trimethoprim-sulfamethoxazole combination therapy for 4 weeks and with a ventriculoperitoneal shunt. The other premature infant, who was in a chronically debilitated state, had infection...
Original Article
The factors associated with the efficacy of indomethacin treatment in premature infants with patent ductus arteriosus
Min Jeong Yoon, Hye Sun Yoon, Sung Hoon Chung, Mi Young Han, Chong Woo Bae
Clin Exp Pediatr. 2007;50(6):531-535.   Published online June 15, 2007
Purpose : Indomethacin treatment is successful in about 90% of patent ductus arteriosus (PDA) in premature infants, but in some, repeated administration or surgical closure is required. The object of the present study is to determine the factors affecting the efficacy of indomethacin treatment and to predict the treatment result. Method : The 29 preterm neonates, admitted to neonatal intensive...
Review Article
Post discharge care of prematurity
Hye Sun Yoon
Clin Exp Pediatr. 2007;50(1):14-19.   Published online January 15, 2007
Advances in neonatal care have been responsible for the improved survival of prematurity but have not resulted in decreased morbidity. Once the high-risk infants is discharged from the hospital, his or her many special care needs do not cease. A well-coordinated multidisciplinary approach is essential in the follow-up care of these infants. Special attention must be given to their growth...
Case Report
A Case of Infantile Hemangioendothelioma of the Liver Treated with Hepatic Embolization and Lobectomy
Jae Seon Kim, Soo Kyung Moon, Hye Sun Yoon, Tae Seok Lee
Clin Exp Pediatr. 2005;48(6):660-664.   Published online June 15, 2005
Infantile hemangioendothelioma(IHE) of the liver is the most common vascular tumor in infants before the age of 6 months. It is a histologically benign tumor with potentially life-threatening complications. The clinical manifestations are variable, ranging from asymptomatic forms to intractable high-output heart failure. In addition, abdominal mass, intraperitoneal hemorrhage due to rupture of mass, respiratory distress, hematologic abnormalities and jaundice...
A Case of Hallermann-Streiff Syndrome with Intra-Uterine Growth Retardation
Seung Yeoun Kim, Young Min Kim, Hye Sun Yoon
Accepted January 1, 1970  
Hallermann-Streiff syndrome is a rare disease; approximately 150 cases have been reported in the world literature. The syndrome consists of proportionate nanism; hypotrichosis; atrophy and extreme thinness of skin, particulary over the facial area; an usual "bird-like" face with mandibular hypoplasia; a prominent thin, pointed nose; congenital cataracts; and severe dental abnormalities. We report a case of Hallermann-Streiff syndrome in...
Case Report
A Case of Townes-Brocks Syndrome
Hong Seop So, Hyun Ju Choi, Hye Sun Yoon, Jin Soon Hwang, Keun Chan Sohn
Clin Exp Pediatr. 2003;46(4):382-384.   Published online April 15, 2003
Townes-Brocks syndrome is an uncommon autosomal dominant condition first described by Townes and Brocks in 1972. We experienced a newborn female who presented with clinical findings of Townes-Brocks syndrome in an otherwise unaffected family. The patient showed the full spectrum of anomalies including anterior placed anus, triphalangeal thumb, preaxial polydactyly, pre-auricular tags, microtia without opening, sensorineural hearing loss and unilateral...
Original Article
Comparison of Antimicrobial Susceptibility of Nosocomial and Community-Acquired Pathogens in Children of Medium-Sized Hospital
Kil Soo Joung, Jae Kook Cha, Kon Hee Lee, Hye Sun Yoon, Wonkeun Song
Clin Exp Pediatr. 1997;40(11):1537-1543.   Published online November 15, 1997
Purpose : We evaluated the identification and antimicrobial susceptibility patterns of nosocomial and community-acquired pathogens in children of the medium-sized hospital. Methods : The 357 bacterial strains isolated from Pediatric department of Dongsan Sacred Heart Hospital were examined the species identification and antimicrobial susceptibility test during the period of March to October 1996. Results : Fifty three strains(15%) of 357 strains were nosocomial pathogens. A...
Case Report
A Case of Congenital Acute Megakaryoblastic Leukemia with Down Syndrome
Nan Yee Kye, Kon Hee Lee, Jae Kook Cha, Hye Sun Yoon, Won Keun Song
Clin Exp Pediatr. 1997;40(4):578-583.   Published online April 15, 1997
We experienced a case of congenital acute megakaryoblastic leukemia with Down syndrome. The patient was admitted due to characteristic facial figure of Down syndrome and abdominal distension. Acute megakaryoblastic leukemia was diagnosed with abundant megakaryoblast in peripheral blood smear, severe myelofibrosis in bone marrow biopsy and positive platelet glycoprotein Ⅲa receptor. On third hospital day, the patient expired due to DIC...
Original Article
A Clinical Study on Infantile Spasms with Prednisolone Therapy
Hye Sun Yoon, Young Hoon Choi, Ho Suk Lee, Yong Mook Choi, Sa Jun Chung
Clin Exp Pediatr. 1996;39(4):522-529.   Published online April 15, 1996
Purpose : Infantile spasms are considered malignant epilepsy of infancy. Primary objectives of treatment are complete control of seizure attack and prevention of further brain damage. The aim of this study is to assess prednisolone(PDL) efficacy in infantile spasms. Methods : From June 1985 to July 1994, 20 children with infantile spasms who were diagnosed at Kyung Hee University Hospital and were...
Changes of Clinical Patterns of the Acute Rheumatic Fever in Korea(Compared report of 1973-1985 with that of 1986-1992)
Hye Sun Yoon, Min Young Park, Wan Young Shin, Byong Soo Sco, Sung Ho Cho
Clin Exp Pediatr. 1995;38(4):470-481.   Published online April 15, 1995
Purpose : The annual incidence of acute rheumatic fever in Korea was not changing during 1980 to 1989 from Nationwide survey in 1991 in spite of talking about scanty outbreak among doctors in recent year.The proportion of patients with acute rheumatic fever among the entire pediatirc inpatients each year was approximately 0.3% and did not change significantly throughout the...
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