Clinical and Experimental Pediatrics

Original Article

The Association of Neonatal Hyperbilirubinemia with UGT1A1 and CYP1A2 Gene Polymorphism in Korean Neonates

Hoon Kang, Jun Ho Lim, Ji Sook Kim, Eun Ryoung Kim, Sung Do Kim, Hee Jae Lee, Joo Ho Chung

Clin Exp Pediatr. 2005;48(4):380-386. Published online April 15, 2005

Purpose : The incidence of nonphysiologic neonatal hyperbilirubinemia is twice as high in East Asians as in whites. Recently, UGT1A1 mutation was found to be a risk factor for neonatal hyperbilirubinemia. In congenitally-jaundiced Gunn rats, which lack expression of UDP-glucuronosyltransferase, alternative pathways can be stimulated by inducers of CYP1A1 and CYP1A2 enzymes. CYP1A2 plays a major role in bilirubin degradation...

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Study of Exchange Phenomenon of Mycoplasma pneumoniae in Children from 1997-2002

Sung Seok Kim, Hoon Kang, Byung Moon Ahn, Won Wook Lee, Eun Ryoung Kim, Soo Yeon Kim, Hyun Pil Cho

Clin Exp Pediatr. 2004;47(1):24-30. Published online January 15, 2004

Methods : We enrolled 504 patients out of 547 patients, who were admitted to the Department of Pediatrics, Sung-Ae and Kwangmyung Sung-Ae General Hospital from November 1996 to October 2002. They were diagnosed as M. pneumoniae pneumonia by clinical characteristics and indirect particle agglutination test of M. pneumoniae. To classify into two groups, the group specific polymerase chain reaction amplification...

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Polymorphism of UDP-glucuronosyltransferase Gene(UGT1A1) of Neonatal Hyperbilirubinemia in Korea

Ki Woong Hong, Hoon Kang, Soo Kim, Ji Sook Kim, Eun Ryoung Kim, Hee Jae Lee, Sheng-Yu Jin, Joo Ho Chung

Clin Exp Pediatr. 2004;47(1):18-23. Published online January 15, 2004

Purpose : The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in whites and its metabolic basis has not been clearly explained. Recently, UDP-glucuronosyltransferase gene (UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia in Japanese and Taiwanese Chinese. We studied whether neonatal hyperbilirubinemia is associated with mutation of UGT1A1, which is a...

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