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Original Article
Clinical experience with 18F-fluorodeoxyglucose positron emission tomography and 123I-metaiodobenzylguanine scintigraphy in pediatric neuroblastoma: complementary roles in follow-up of patients
Tae Young Gil, Do Kyung Lee, Jung Min Lee, Eun Sun Yoo, Kyung-Ha Ryu
Clin Exp Pediatr. 2014;57(6):278-286.   Published online June 30, 2014
Purpose

To evaluate the potential utility of 123I-metaiodobenzylguanine (123I-MIBG) scintigraphy and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) for the detection of primary and metastatic lesions in pediatric neuroblastoma (NBL) patients, and to determine whether 18F-FDG PET is as beneficial as 123I-MIBG imaging.

Methods

We selected 8 NBL patients with significant residual mass after operation and who had paired 123I-MIBG and 18F-FDG PET images...

Review Article
Recent advances in the diagnosis and management of childhood acute promyelocytic leukemia
Eun Sun Yoo
Clin Exp Pediatr. 2011;54(3):95-105.   Published online March 31, 2011

Since the successful introduction of all-trans-retinoic acid (ATRA) and its combination with anthracycline-containing chemotherapy, the prognosis for acute promyelocytic leukemia (APL) has markedly improved. With ATRA and anthracycline-based-chemotherapy, the complete remission rate is greater than 90%, and the long-term survival rate is 70-89%. Moreover, arsenic trioxide (ATO), which was introduced for APL treatment in 1994, resulted in excellent remission rates...

Neutropenia in children
Eun Sun Yoo
Clin Exp Pediatr. 2009;52(6):633-643.   Published online June 15, 2009
Neutropenia is defined as an absolute neutrophil count (ANC) of ＜1,500/µL, and the severity of neutropenia generally can be graded as mild (1,000-1,500/µL), moderate (500-1,000/µL), or severe (＜500/µL). This stratification aids in predicting the risk of pyogenic infection because the susceptibility to life-threatening infections is significantly increased in patients with prolonged episodes of severe neutropenia. Especially cancer-related neutropenia carry significant...
Original Article
Weaning food practice in children with iron deficiency anemia
Joo Hee Chang, Woo Sik Cheong, Yong Hoon Jun, Soon Ki Kim, Hung Sik Kim, Sang Kyu Park, Kyung Ha Ryu, Eun Sun Yoo, Chuhl Joo Lyu, Kun soo Lee, Kwang Chul Lee, Jae Young Lim, Du Young Choi, Byung Kyu Choe, Eun Jin Choi, Bong Soon Choi
Clin Exp Pediatr. 2009;52(2):159-166.   Published online February 15, 2009
Purpose : Iron deficiency anemia (IDA) is one of the most common nutritional deficiencies in children on a weaning diet. We investigated weaning practices in infants and children, as well as their mothers' knowledge about weaning. Methods : We investigated 129 children with IDA and 166 without IDA (aged 6-36 months) who had visited 10 university hospitals between March 2006...
Bacterial meningitis in children experienced at a university hospital, 1993-2006
Sung Yoon Cho, Tae Yeon Kim, Hyunju Lee, Kyung Hyo Kim, Eun Sun Yoo, Hae Soon Kim, Eun Ae Park, Kyung Ha Ryu, Jeong Wan Seo, Sejung Sohn, Seung Joo Lee
Clin Exp Pediatr. 2008;51(10):1077-1084.   Published online October 15, 2008
Purpose : Despite the seriousness of bacterial meningitis in children, there is little information on the incidence, causative organisms, mortality rate and age distribution. We studied the frequency by age group and causal pathogens, and clinical characteristics in children with bacterial meningitis in the private sector in Korea. Methods : The medical records containing the data on bacterial meningitis patients...
Usefulness of Low Risk Criteria for Serious Bacterial Infection Among Febrile Infants Younger than Three Months of Age
So Hyun Kim, Ji Ah Jung, Hae-Soon Kim, Eun Sun Yoo, Sejung Sohn, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 2002;45(8):967-972.   Published online August 15, 2002
Purpose : A retrospective study was undertaken to evaluate the usefulness of low risk criteria for identifying febrile infants younger than three months unlikely to have serious bacterial infection. Methods : We conducted a retrospective study of 527 infants younger than three month with a axillary temperature ≥37.4℃. If they met the following all four criteria, appear well, WBC 5,000- 20,000/mm3,...
A Clinical Manifestation of Meckel's Diverticulum
Jin Beom Lee, Yong Soon Lee, Eun Sun Yoo, Hae Soon Kim, Se Jeong Son, Eun Ae Park, Seung Joo Lee, Sun Hee Sung, Jeong Wan Seo
Clin Exp Pediatr. 2002;45(4):466-472.   Published online April 15, 2002
Purpose : The diagnosis of Meckel's diverticulum is difficult and delayed because it presents with various clinical symptoms. We evaluated clinical, imaging and pathologic findings of Meckel's diverticulum to facilitate detection of Meckel's diverticulum in children. Methods : Review of clinical, imaging, surgical and pathological findings in 10 children aged 7 days to 14 years with Meckel's diverticulum during an 8-year...
Erratum
Recent Advance of Hematopoietic Stem Cell Gene Therapy
Eun Sun Yoo
Clin Exp Pediatr. 2001;44(3):326-333.   Published online March 15, 2001
Case Report
A Case of Hepatoblastoma with Precocious Puberty
Chang Won Choi, Hyun Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Sei Won Yang, Hyo Seop Ahn
Clin Exp Pediatr. 2000;43(2):288-293.   Published online February 15, 2000
Hepatoblastoma is the most common primary malignant liver tumor in childhood. Most cases are boys generally below three years of age. Hepatoblastoma are associated with various non-metastatic syndromes. Rarely, human chorionic gonadotropin may be produced by the tumor. Ectopic gonadotropin production from this source is a rare cause of precocious puberty in boys. Since a report by Behrendt in 1931,...
Two Cases of Thymic Carcinoma in Childhood
Young Ah Lee, Jin Young Park, Hye Lim Jung, Moon Soo Par, Hyoung Soo Choi, Eun Sun Yoo, Hyo Seop Ah
Clin Exp Pediatr. 1999;42(3):424-429.   Published online March 15, 1999
Thymic carcinoma is a malignant neoplasm arising from the thymic epithelium, and is known to be extremely uncommon in the pediatric population. The tumor is clinically highly aggressive with frequent local intrathoracic spread and extrathoracic metastases detected in the majority of patients at initial diagnosis and often shows minimal or no response to conventional chemotherapy. We experienced two pediatric patients...
Original Article
Immunomodulation Therapy in Aplastic Anemia : Relapse Rate, Complications and Long-term Survival During Follow-up for More than 1 Year
Jun Ah Lee, Hyoung Jin Kang, Hyo Jeong Han, Hyoung Soo Choi, Eun Sun Yoo, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(6):775-784.   Published online June 15, 1998
Purpose : We evaluated the response to immunomodulation therapy, long-term survival and relapse rate of aplastic anemia during follow-up for more than 1 year. Methods : Twenty-eight children, with moderate to severe aplastic anemia were followed for more than one year and 7 children expired after therapy, were analyzed. Antilymphocyte globulin(ALG) or antithymocyte globulin(ATG) by itself was given to 27 patients, and cyclosporine A(CsA)...
Random Urine Ca/Cr Ratio in Healthy Neonates
Hea Young Lee, So Young Park, Eun Sun Yoo, Eun Ae Park, Seung Joo Lee
Clin Exp Pediatr. 1998;41(3):378-382.   Published online March 15, 1998
Purpose : Recently, in high risk preterm infants, we experienced high incidence of hypercalciuria, nephrolithiasis & nephrocalcinosis. To screen hypercalciuria, we need the normal value of random urine Ca/Cr ratio in healthy neonates according to gestational age, postnatal age, milk and calcium intake. Methods : Random urine Ca/Cr ratio was checked in 260 healthy full-term infants at the 2-7th day, and...
Induction Chemotherapy with BH-AC, Idarubicin, and 6-Thioguanine in Childhood Acute Myelogenous Leukemia
Hyo Jeong Han, Hyoung Jin Kang, Jun Ah Lee, Hyoung Soo Choi, Hyeon Jin Park, Ki Woong Seong, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(2):209-215.   Published online February 15, 1998
Purpose : We have undertaken this study to evaluate the effects of induction chemotherapy involving BH-AC, idarubicin, and 6-thioguanine(6-TG). Methods : BH-AC 300mg/m2/day was administered intravenously over three hours for seven consecutive days. Idarubicin 12mg/m2/day was administered intravenously for three days. 6-TG 100 mg/m2/day was administered orally for seven days. Intrathecal ara-C was administered on the first day of treatment. Results...
A Result of Treatment of Malignant Germ Cell Tumors in Childhood
Hyoung Jin Kang, Jun Ah Lee, Hyo Jeong Han, Hyoung Su Choi, Hyeon Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn, Kwi Won Park, Byung Keu Cho, Hwang Choi, Chul Woo Kim
Clin Exp Pediatr. 1997;40(12):1707-1718.   Published online December 15, 1997
Purpose : Germ cell tumors have variable clinical characteristics according to the age, sex, primary site, and pathologic diagnosis. To provide the therapeutic principle, the clinical characteristics, response to the treatment, and prognostic factors were analyzed. Methods : Medical records of 57 children who were diagnosed as malignant germ cell tumor in Seoul National University Children' s Hospital from January 1986 till June 1996 were...
The Risk Factors related to Recurrent Intussusception by Ultrasonography
Eun sun Yoo, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 1996;39(12):1707-1716.   Published online December 15, 1996
Purpose : We investigate the risk factors of recurrence after first intussusception. Methods : We have studied the relationship of the clinical features and ultrasonographic findings and the risk of recurrent intussusception in 97 patients with reduced intussusception including 22 recurrent intussusception who admitted at the department of pediatrics at Ewha Womans University Mok-dong hospital from September 1993 to Feburary 1996. Results...
Arterial Oxygen Desaturation after Salbutamol Nebulization in Wheezy Infants and Children
Eun Sun Yoo, Jung Won Seo, Seung Joo Lee
Clin Exp Pediatr. 1996;39(7):953-961.   Published online July 15, 1996
Purpose : Nebulized selective β2-adrenoreceptor agonists have been widely used in acute asthma and selectively in acute bronchiolitis. However, nebulized salbutamol have been reported to cause arterial oxygen desaturation in some of the acute bronchiolitis and severe asthma patients. This may be the results of a paradoxical bronchoconstriction linked to acidic and hyper-osmolar nebulized salbutamol solution and etc. We assessed the changes in arterial...
Serum IgE Standardized for Age in Korean Children and Its Diagnostic Reliability in Childhood Asthma
Myung Su Lee, Eun Sun Yoo, Hye Sun Kim, Eun Ae Park, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 1996;39(3):397-403.   Published online March 15, 1996
Purpose : IgE was identified by Ishizaka as an antibody that is reacted at Type I hypersensitivity reaction, and has been used in the diagnosis of allergic disease and the differential diagnosis of extrinsic and intrinsic asthma. But there was some confusing in the diagnosis because of the broad range of measured serum IgE. Recently it was reported that serum IgE...
Natural Anti-PRP Antibody Levels to Haemophilus Influenzae Type b(Hib) and Changes of Antibody Levels after Three Doses of Vacination
Eun Sun Yoo, Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1995;38(9):1201-1209.   Published online September 15, 1995
Purpose : The Haemophilus influenzae type b(Hib) was the most common cause of meningitis and invasive bacterial disease mainly in children 2 months to 5 years old in the United States. The conjugated Hib vaccines have recently been licensed by the US Food and Drug Administration for routine use in infants beginning at 2 months of age, and the Infectious...
Case Report
A Case of Congenital T Cell Lymphoblastic Lymphoma
Eun Sun Yoo, Young Mi Hong, Kyung Hee Kim, Hae Soo Gyu, Eun Chul Chung
Clin Exp Pediatr. 1994;37(9):1296-1304.   Published online September 15, 1994
T cell lymphoblastic lymphoma is characterized by immature lymphoid cells that are indistinguishable from the lymphoblasts and prolymphocytes of acute lymphoblastic leukemia. Several characteristic clinical features of lymphoblastic lymphoma, with include a high male-to-female ratio, a relatively high incidence in older children and young adults, the frequent presence of mediastinal involvement at the time of diagnosis. Also, this disease is...
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