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Original Article
Infection
Viral load and rebound in children with coronavirus disease 2019 during the first outbreak in Daegu city
Mi Ae Chu, Yoon Young Jang, Dong Won Lee, Sung Hoon Kim, Namhee Ryoo, Sunggyun Park, Jae Hee Lee, Hai Lee Chung
Clin Exp Pediatr. 2021;64(12):652-660.   Published online October 12, 2021
Question: What is the natural course of viral load in children with coronavirus disease 2019 (COVID-19)?
Finding: A significant number of patients still had a relatively high viral load once clinically asymptomatic. Nearly half of the patients experienced viral rebound, which contributed to prolonged viral detection in their respiratory specimens.
Meaning: Further studies are needed to determine the clinical significance of viral rebound in asymptomatic or mild pediatric cases of COVID-19.
Cardiology
Vasovagal syncope with mild versus moderate autonomic dysfunction: a 13-year single-center experience
Han Eoul Lee, Dong Won Lee
Clin Exp Pediatr. 2022;65(1):47-52.   Published online June 1, 2021
Question: It is well known that autonomic dysfunction contributes to vasovagal syncope (VVS). Does the degree of autonomic dysfunction contribute to clinical manifestations, diagnostic methods, treatment, and prognosis?
Finding: The clinical manifestations, diagnostic methods, treatment, and prognosis differ between patients with mild and moderate degrees of autonomic dysfunction.
Meaning: VVS is caused by autonomic dysfunction, but autonomic dysfunction severity need not be classified.
Clinical Note
Neonatology (Perinatology)
Management of the first newborn delivered by a mother with COVID-19 in South Korea
Eun-Kyung Lee, Won Duck Kim, Dong won Lee, Sang-Ah Lee
Clin Exp Pediatr. 2020;63(9):373-375.   Published online July 13, 2020
Question: How to manage the newborn born to the coronavirus disease 2019 (COVID-19) pregnant?
Finding: Medical staff managed the delivery and neonatal care of a COVID-19 pregnant patient was based on the “Guidelines for COVID-19 response.”
Meaning: We desire that our management will help treat for subsequent patients and there should be updated continuously the prevention and control consensus strategies for newborn COVID-19.
Original Article
Cardiology
Relationship between vitamin D levels and intravenous immunoglobulin resistance in Kawasaki disease
Jae Sung Jun, Young Kwon Jung, Dong Won Lee
Clin Exp Pediatr. 2017;60(7):216-220.   Published online July 31, 2017
Purpose

Vitamin D is associated with various pathological conditions such as cardiovascular diseases and cancer. We investigated the relationship between vitamin D and Kawasaki disease (KD).

Methods

We performed a retrospective review of the medical records of patients with KD between February 2013 and March 2016 in Daegu Fatima Hospital. Study participants were grouped according to vitamin D serum concentration. Group 1 included...

Predictors of nonresponse to intravenous immunoglobulin therapy in Kawasaki disease
Hyo Min Park, Dong Won Lee, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 2013;56(2):75-79.   Published online February 25, 2013
Purpose

It has been reported that 10% to 20% of children with Kawasaki disease (KD) will not respond to intravenous immunoglobulin (IVIG) treatment. In this study, we aimed to identify useful predictors of therapeutic failure in children with KD.

Methods

We examined 309 children diagnosed with KD at the Kyungpook National University Hospital and the Inje University Busan Paik Hospital between January 2005...

Case Report
Secondary renal amyloidosis in a 13-year-old girl with bronchiectasis
Eun Ae Yang, Dong Won Lee, Myung Chul Hyun, Min Hyun Cho
Clin Exp Pediatr. 2010;53(7):770-773.   Published online July 31, 2010

A 13-year-old girl was diagnosed with non-cystic fibrosis (CF)-related multifocal bronchiectasis accompanied by nephrotic-range proteinuria of unknown cause. On renal biopsy, there were many segmental homogeneous deposits of amyloid tissue with positive Congo red staining in the glomeruli and interstitium. On electron microscopy, relatively straight, non-branching, randomly arranged amyloid fibrils were showed in the mesangium of the glomeruli. These fibrils...

Original Article
NT-proBNP as a useful tool in diagnosing incomplete Kawasaki disease
Dong Won Lee, Yeo Hyang Kim, Myung Chul Hyun, Tae Chan Kwon, Sang Bum Lee
Clin Exp Pediatr. 2010;53(4):519-524.   Published online April 15, 2010
Purpose : To determine the efficacy of the N-terminal fragment of B-type natriuretic peptide (NT-proBNP) as a useful diagnostic method in children with incomplete Kawasaki disease (KD). Methods : Ninety-six patients who were diagnosed as having KD between January 2008 and June 2009 were enrolled in the study. American Heart Association recommendations for diagnosis were used, and patients were divided into...
Clinical features and surgical results of ruptured sinus of valsalva aneurysm
Tae Ho Lee, Dong Won Lee, Joon Yong Cho, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 2006;49(3):287-291.   Published online March 15, 2006
Purpose : Aneurysms of sinus valsalva are rare anormalies thought to be primarily congenital in origin, progressing into death by acute heart failure in cases of rupture. Surgical correction is the only method of treatment. With these clinical implications, we reviewed the clinical characteristics and surgical results of patients with ruptured sinus of valsalva aneurysm. Methods : Between January 1991...
Usefulness of Intraoperative Transesophageal Echocardiography
Dong Won Lee, Byung Mok Kim, Sei Young Kim, Yeo Hyang Kim, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 2004;47(12):1281-1286.   Published online December 15, 2004
Purpose : This study was undertaken to learn the usefulness, cost-effectiveness and safety of intraoperative transesophageal echocardiography(ITEE) during open heart surgery for congenital heart diseases. Methods : The usefulness and safety of ITEE were assessed in 254 patients who underwent open heart surgery for congenital heart diseases from January 1, 2001 to June 30, 2003, with retrospective chart reviews and a...
Case Report
A Case of Infantile Acute Hemorrhagic Edema
Hyun Jeong Lee, Dong Won Lee, Si Yong Kim, Baik Kee Cho, Chang Kyu Oh
Clin Exp Pediatr. 1996;39(8):1168-1172.   Published online August 15, 1996
Infantile acute hemorrhagic edema(IAHE) is a variant of leukocytoclastic vasculitis which is characterized by painful edematous purpura of cockade pattern on the head and distal extremities. The lesions are limited to the skin and complete recovery occurs within 1 to 3 weeks. Recently, it is accepted as a separate entity from Henoch-Schönlein purpura. A nine month-old boy presented multiple cockade ecchymotic plaques and inflammatory...
Original Article
A Survey and Clinical Study on Neonatal Disease Who were Admitted from Outside.
Moon Ho Chung, Dong Won Lee, Soo Ji Moon, Chong Moo Park
Clin Exp Pediatr. 1983;26(7):647-654.   Published online July 31, 1983
The first 28 days following birth, the neonatal pericd, is a vitally important period. This is a period of adjustment from intrauterine to extrauterine life involving considerable physiological adaptation and is associated with high morbidity with a consequent high mortality rate. Though mother & child health care have been provided in Korea, inadequate prenatal care and low incidence of hospital delivery bring on...
Case Report
A Case of Congenital Hypertrophic Pylocric Stenosis Associated with Gastroesophageal Reflux.
Eui Soo Park, Dong Won Lee, Woo Gill Lee, Poong Man Jung
Clin Exp Pediatr. 1982;25(2):190-194.   Published online February 28, 1982
Congenital hypertrophic pyloric stenosis is characterized by projectile vomiting and pyloric thickening, and must be differentiated with gastroesophageal reflux. Gastroesophageal reflux may defined as relaxation of lower esophageal sphincter causing return of stomach content into eophagus, and frequently associated with hiatal hernia. The authors presented a case, having congenital hypertrophic pyloric stencsis and gastroesophageal reflux simultaneously which must be differentiated...
A Case of Ludwig Angina.
Dong Won Lee, Jin Woo Han, Woo Gill Lee
Clin Exp Pediatr. 1982;25(1):89-91.   Published online January 31, 1982
Ludwig angina is known as rapidly spreading, diffuse, gangrenous cellulitis of submandibular, submental and sublingual spaces and upper cervical region. We have experienced a case of Ludwig angina in 7 years old female child and reviewed the pertinent literautres briefly.
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