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Original Article
A Study of Relation between Stable Microbubble Rating and Pulmonary Surfactant Concentration in vitro
Seong Yong Jung, Thi Hyung Park, Chong Woo Bae, Chang Il Ahn
Clin Exp Pediatr. 1994;37(8):1048-1054.   Published online August 15, 1994
Respiratory distress syndrome (RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventilatory techniques. After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement produced exellent...
Improvement of Thoracic Pressure-Volume, Complincace and Histological Characteristics in Premature Newborn Rabbit after Treatment of Bovine Purified Natural Surfactant-Phospholipid
Chong-Woo Bae, Chang Il Ahn, Haruo Maeta, Tetsuro Fujiwara
Clin Exp Pediatr. 1994;37(2):157-166.   Published online February 15, 1994
We had previously reported the purification of bovine lung natural surfactant-phospholoipd (PNS-L) and the assessment of it's surface physical properties in vitro. To observe the clinical effectiveness of PNS-L in vivo, the degree of improvement of thoracic pressure-volume, compliance and histological changes following PNS-L instillation in premature rabbits with respiratory distress syndrome (RDS) were investigated. Rabbits, delivered prematurely by cesarean section...
Auditory Brain Stem Responses and Neurological Disorders in Children
Chang Il Ahn, Sa Jun Chung
Clin Exp Pediatr. 1994;37(2):149-156.   Published online February 15, 1994
Original Article
Changes in Somatostatin Immunoreactive Neurons in Rat Corebral Cortes after Systemic Kainic acid Administration
Myung Yeun Lee, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1993;36(9):1279-1290.   Published online September 15, 1993
This study was aimed to clarify the effects of systemic kainic acid(KA) administration(10mg/kg i.p.) on somatostatin containing neurons, and to examine the distribution of somatostain immunoreactive neurons in the cerebral cortex of the rats. Animals were sacrificed at three time points at the two, six, and ten days after the injection of KA. Thirty-six rats were observed by using the free-floating immunohistochemical...
Clinical Studies of Henoch-Schölein Purpura Which was Considered as Acute Abdomen
Seong Young Jeong, Seong Yun Cho, Chio Heong Park, Seong Ho Cha, Byoung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1993;36(8):1124-1132.   Published online August 15, 1993
Henoch-Schölein purpura is a common pediatric disease presenting most frequently with skin, gastrointestinal, joint and renal manifestations. But in cases are infrequently only severe gastointestinal manifestations. It is hard to diagnose promptly and exactly. Clinical manifestations and laboratory findings were observed and analyzed in 20 cases with Henoch-Schölein purpura which were considered as acute abdomen, hospitalized at Kyung Hee university Hospital...
Case Report
A Case of Congenital Goiter with Congenital Hypothyroidism due to Organification Defect
Ik Hee Lee, Sung Yong Jung, Thi Hyung Park, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1993;36(7):1002-1008.   Published online July 15, 1993
We experienced a case of congenital goiter with congenital hypothyroidism in 45 dayold male, who complained of respiratory difficulty and anterior neck mass. After admission, he was diagnosed congenital hypothyroidism by the clinical manifestations and laboratory tests including biochemistry, radioimmunoassay, radioisotope study, perchlorate discharge test, and bone radiography. We obtained positive finding at the perchlorate discharge test and found that his...
Original Article
Atypical Presentation of Acute Glomerulonephritis
Hyun Ho Shin, Thy Hyung Park, Sung Ho Cha, Byoung Soo Cho, Chang Il Ahn, Young Tae Ko, Moon Ho Yang
Clin Exp Pediatr. 1993;36(7):987-993.   Published online July 15, 1993
Form March 1982 to December 1991, 110 cases of typical post-streptococcal glomerulonephritis and 25 cases of Atypical acute glomerulonephritis were clinically investigated at Department of pediatrics, Kyung Hee University Hospital, and follwing Data were obtained. 1) Male to Femal ratio was 1.8:1 (Atypical AGN). Peak incidence was from 7 to 12 years. 2) The most common preceding infections were upper respiratory infection,...
A Clinical Study on Patients with Porencephaly
Sung Yoon Cho, Jai Yoon Kim, Kwang Sun Han, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1993;36(7):975-981.   Published online July 15, 1993
Porencephaly is relatively rare condition defined by a defect or cavity in the cerebrum owing to a developmental malformation or to a destructive lesion. Forty-five porencephaly patients diagnosed by Brain CT were clinically analyzed and the following results were obtained. 1) By the age group presenting initial symptoms, the peak incidence was from 1 month to below 3 years old. 2) In initial...
Clinical Study and Availability of Ultrasonography in Hemorrhagic Cystitis
Jin Park, Chi Hyung Park, Chong Woo Bae, Sung Ho Cha, Byoung Soo Cho, Chang Il Ahn, Young Tae Ko, Sun Wha Lee
Clin Exp Pediatr. 1992;35(12):1722-1727.   Published online December 15, 1992
Acute hemorrhagic cystitis characterized by gross hematuria and symptoms of bladder irritation occurs in children as a self-limited disease that must be differentiated from serious renal disease. We analyzed 22 cases of hemorrhagic cystitis which were managed in the Dept. of pediatrics, Kyung Hee university hospital and present the availability of bladder sonography for diagnosis of hemorrhagic cystitis and for follow-up. The...
Hypercalciuria Associated with Nephropathy (diagnosis by renal biopsy)
Hyun Ho Shin, Jae Yoon Kim, Chong Woo Bae, Sung Ho Cho, Byoung Soo Cho, Chang Il Ahn, Young Tae Ko, Moon Ho Yang
Clin Exp Pediatr. 1992;35(11):1509-1513.   Published online November 15, 1992
Idiopathic hypercalciuria is defined as excessive urinary excretion of calcium in normocalcemia without any primary cause. We performed the sono-guided percutaneous renal biopsy for patients of recurrent hematuria, persistent microscopic hematuria, proteinuria and RBC cast to evaluate underlying nephropathy. We could obtained the following results 1) The age at the renal biopsy ranged from 3 years to 14 years. Sex ratio is 1.9:1...
Case Report
A Case of Seronegative Enthesopathy and Arthropathy Syndrome (SEA Syndrome)
Il Su Kim, Jae Yoon Kim, Byung Su Cho, Sung Ho Cha, Chang Il Ahn
Clin Exp Pediatr. 1992;35(10):1459-1462.   Published online October 15, 1992
Seronegative enthesopathy and arthropathy (SEA) syndrome is characterized by male predominance, late age onset, positive family histories of arthritis, oligoarthropathy, axial skeleton involvement, the presence of the B27 histocompatiboility antigen. It has been reported by Rosenberg and Petty in 1982. Early recognition of this syndrome destined to develop seronegative spondyiarthropathy is necessary to prevent axial spine dysfunction and defomity and...
Original Article
A case of lipodystrophia centrifugalis abdominalis infantilis.
Kyu Young Lee, Sung Ho Cha, Byoung Soo Cho, Chang Il Ahn, Woo Young Sim, Choong Rim Haw, Moon Ho Yang
Clin Exp Pediatr. 1991;34(10):1452-1457.   Published online October 31, 1991
We report a case of lipodystrophia centrifugalis abdominalis infantilis in 24 month male. At age 18 months, his mother noticed a fairly well-defined depression of skin in the both inguinal and axillary area, which gradually spread centrifugally to the lower portion of abdomen and total inguinal and axillary region. The laboratory findings were unremarkable. Biopsy showed absense of subcutaneous fat in the affected area.
A case of nephrogenic diabetes insipidus due to vesicoureteral reflux.
Yong Bae Suh, Jong Yul Jeon, Sung Ho Cha, Byoung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1991;34(9):1299-1304.   Published online September 30, 1991
Nephrogenic diabetes insipidus is a disorder characterized by polydipsia and polyuria resulting from failure of the renal tubules and collecting ducts to respond to antidiuretic hormone despite elevated blood levels of antidiuretic hormone. We experienced a case of nephrogenic diabetes insipidus in 13 months-old girl probably secondary to vesicoureteral reflux grade IV. The clinical manifestations were extreme thirst, polydipsia and polyuria. Family history was nonspecific and...
Surfactant replacement therapy in neonatal respiratory distress syndrome.
Chan Ok Park, Boung Yul Lim, Byeong Gie Yeo, Ji Ho Song, Eun Kyung Sohn, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1991;34(9):1211-1222.   Published online September 30, 1991
Respiratory distress syndrome (RDS) in tiny infants remains a major medical challenge as they are less tolerant of supportive care. In 1959, after identification of the pulmonary surfactant (S), S replacement therapy were used to treat RDS. This idea was first successfully tested on RDS infants by Fujiwara, et. al” in 1980. Now the trial and use of S for the treatment in RDS...
Experimental study on the effect of phenobarbital on Na+, K+-activated adenosine triphosphatase in microsome fractions of mouse brain.
Seo Kyu Kim, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1991;34(7):959-970.   Published online July 31, 1991
Na+, K+-activated adenosine triphosphatase (Na+, K+-ATPase) is known to play a role as a trigger in neurotransmitter release and may also affect the transport of calcium ion (Ca++). By doing so, Na+, K+-ATPase, as an anticonvulsant, can modify the excitability level of cells in epilepsy. In order to elucidate the possible mechanisms of neuropharmacological interaction between Na+, K+.ATPase and phenobarbital, serial experimental studies were...
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