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Case Report
Immunology
A novel BTK gene mutation, c.82delC (p.Arg28 Alafs*5), in a Korean family with X-linked agammaglobulinemia
Jeongeun Lee, Minhee Rhee, Taek Ki Min, Hae In Bang, Mi-Ae Jang, Eun-Suk Kang, Hee-Jin Kim, Hyeon-Jong Yang, Bok Yang Pyun
Clin Exp Pediatr. 2016;59(Suppl 1):S49-S52.   Published online November 30, 2016

X-linked agammaglobulinemia (XLA) is a hereditary humoral immunodeficiency that results from Bruton’s tyrosine kinase (BTK) gene mutations. These mutations cause defects in B-cell development, resulting in the virtual absence of these lymphocytes from the peripheral circulation. Consequently, this absence leads to a profound deficiency of lg all isotypes, and an increased susceptibility to encapsulated bacterial infections. A 15-month-old Korean boy...

Original Article
Identification of major rice allergen and their clinical significance in children
You Hoon Jeon, Se Jo Oh, Hyeon Jong Yang, Soo Young Lee, Bok Yang Pyun
Clin Exp Pediatr. 2011;54(10):414-421.   Published online October 31, 2011
Purpose

Recently, an increase in the number of patients sensitized to rice allergen with or without clinical symptoms has been reported. This study was designed to determine the major allergens in rice and their clinical significance.

Methods

Twenty-four children (15 boys and 9 girls; mean age, 16.3 months) with allergic disease, who were sensitized to rice antigen (by UniCAP) in the Pediatric Allergy...

Review Article
Oral food challenges in children
Hye Yung Yum, Hyeon Jong Yang, Kyung Won Kim, Tae Won Song, Woo Kyung Kim, Jung Hee Kim, Kang Mo Ahn, Hyun Hee Kim, Soo Young Lee, Bok Yang Pyun
Clin Exp Pediatr. 2011;54(1):6-10.   Published online January 31, 2011

Many patients assume that allergic reactions against foods are responsible for triggering or worsening their allergic symptoms. Therefore, it is important to identify patients who would benefit from an elimination diet, while avoiding unnecessary dietary restrictions. The diagnosis of food allergy depends on the thorough review of the patients's medical history, results of supplemented trials of dietary elimination, and in...

Original Article
A study of the frequency and characteristics of minor clinical manifestations in children with atopic dermatitis
Ji Eun Cho, You Hoon Jeon, Hyeon Jong Yang, Bok Yang Pyun
Clin Exp Pediatr. 2009;52(7):818-823.   Published online July 15, 2009
Purpose : We aimed to evaluate the frequency and characteristics of minor clinical manifestations of atopic dermatitis (AD) in Korean children to aid the diagnosis and treatment of AD. Methods : From April 2007 to December 2007, we enrolled 106 children (aged 1 month [infants] to 15 years) diagnosed with AD at the Pediatric Allergy Respiratory Center in Soonchunhyang University Hospital....
Clinical manifestations patterns of allergic disease in Korean children under the age of 6 : multi-center study
Dong Il Kim, Hyeon Jong Yang, Young Mean Park, Yeong Ho Rha, Ji Tai Choung, Bok Yang Pyun
Clin Exp Pediatr. 2008;51(6):640-645.   Published online June 15, 2008
Purpose : It is widely known that allergic diseases progress through an allergic march. However, there have not been any recent reports in Korea on how the diseases progress. Methods : Parents who visited one of the Pediatric Allergy Clinics of four university hospitals in Seoul with a child under the age of 6 years during the period from May...
The effect of education and training with balloons on pulmonary function test in children
Yong Hee Hong, Sun Mi Ha, You Hoon Jeon, Hyeon Jong Yang, Bok Yang Pyun
Clin Exp Pediatr. 2008;51(5):506-511.   Published online May 15, 2008
Purpose : The results of pulmonary function test (PFT) in children are variable according to the patient's cooperation and comprehensiveness. This study has intended to figure out the effectiveness of pre-education and training with balloons on PFT in children. Methods : One hundred six children mean aged 9.35?.92 years were tested. All participants performed PFT twice in 30 minutes intervals....
Therapeutic comparison between low-dose sustained-release theophylline dry syrup and capsule in children with mild persistent asthma
Hyun Seung Lee, Hae Kyung Lee, Hi Jeong Kwon, Jeong Hee Kim, Yeong Ho Rha, Jin Tack Kim, Young Ho Kim, Hae Rhan Lee, Bok Yang Pyun
Clin Exp Pediatr. 2007;50(3):284-291.   Published online March 15, 2007
Purpose : Theophylline has recently been reported to have concurrent anti-inflammatory effects at low therapeutic plasma concentrations which are below the doses at which significants, clinically useful bronchodilatation is evident. Sustained-release formulation in capsule and dry syrup forms were developed to reduce its adverse effects and improve its clinical effects. We compared the therapeutic effects of theophylline dry syrup and...
Review Article
Atopic dermatitis
Bok Yang Pyun
Clin Exp Pediatr. 2006;49(6):589-592.   Published online June 15, 2006
Atopic dermatitis is estimated to affect 15-20% of the childhood population and there id considerable evidence that the prevalence is increasing. But it is frequently under diagnosed and inappropriately treated yet. Atopic dermatitis can have a large social;. emotional and financial effect on the child and their family. Atopic dermatitis also commonly predated the development of asthma and allergic rhinitis....
Clinical Lecture
Guideline for the Management of Childhood Asthma
Bok Yang Pyun
Clin Exp Pediatr. 2001;44(7):727-731.   Published online July 15, 2001
Erratum
Distribution of Anti-Mumps IgM Antibody in Children Presumptively Diagnosed of Mumps
Sung Hee Oh, Do Hack Yum, Jin Han Kang, Young Mo Sohn, Hoan Jong Lee, Bok Yang Pyun, Young Jin Hong, Chang Hwi Kim
Clin Exp Pediatr. 2001;44(1):17-25.   Published online January 15, 2001
Purpose : Outbreaks of mumps continue to occur, even though the number of patients diagnosed of mumps has decreased considerably with the widespread use of vaccine. The accurate diagnosis of mumps is needed to understand the epidemiology of mumps and analyse the safety and effectiveness of vaccine. Therefore, we attempted to appraise the accuracy of provisional diagnosis of mumps in...
Original Article
Antibody Response and Adverse Reaction Following Immunization with MMR Vaccine Produced on Human Diploid Cells in Korean Children
Sung Hee Oh, Jin Han Kang, Young Mo Sohn, Hoan Jong Lee, Bok Yang Pyun, Chang Hwi Kim
Clin Exp Pediatr. 2000;43(4):489-495.   Published online April 15, 2000
Purpose : This prospective study was performed to evaluate the immunogenecity and safety of MMR vaccine(Triviraten Berna¢c) in Korea children. Methods : Seventy-three infants aged between 12 to 18 months were recruited from several university hospitals between December 1995 to June 1996. MMR vaccine(Triviraten Berna¢c) was administrered and blood was obtained before and 6-10 weeks after vaccination. IgG antibodies against measles,...
Immunologic Considerations in the Pathogenesis of Chronic and Recurrent Sinusitis in Children
Jun Ki Jung, Bok Yang Pyun, Sang Mann Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1996;39(2):207-217.   Published online February 15, 1996
Purpose : Although the chronic sinusitis is one of the most common and troublesome respiratory diseases in children, the pathogenesis still remains unclear. It is suggested that many of the immunologic factors including allergic conditions may contribute the nasal inflammatory changes. This study was designed to evaluate and demonstrate the possible role of various immunologic factors on the pathogenesis of...
Medical Lecture Course
Role of Cytokines in Allergic Diseases
Bok Yang Pyun
Clin Exp Pediatr. 1994;37(6):735-740.   Published online June 15, 1994
Original Article
A Clinical and Diagnostic Study of the Allergic Rhinitis in Children.
Hyun Kuk Kim, Min Yong Oum, Bok Yang Pyun, Sang Jhoo Lee
Clin Exp Pediatr. 1990;33(2):189-195.   Published online February 28, 1990
Recently many studies and development of allergology especially in allergic rhinitis have been carried out and the number of allergic rhinitis patients has been increased. In order to get basic clinical information, the authors performed clinical and diagnostic analysis with 132 cases complaining of nasal stuffness, watery rhinorrhea or sneezing who visited the out- patient department of Pediatrics, Soon Chun Hyang University Hospital from...
An Epidemiological Study of Bronchial Asthma in Children Who Visited the Emergency Room.
Ju Kwan park, En Jung Kim, Bok Yang Pyun, Sang Jhoo Lee
Clin Exp Pediatr. 1989;32(2):215-222.   Published online February 28, 1989
Presently, an increasing incidence of Bronchial asthma in children is of concern to medical professionals. Worldwide data from surveys indicate a wide range for the prevalence of childhood asthma, it has been estimated that 5-10% of the young population. An epidemiological approach was used to test the prevalence of bronchial asthma out of all pediatric cases referred to the emergency room. 248 cases were selected...
Case Report
A Case of Congenital Nonspherocytic Hemolytic Anemia.
Tae Sook Kim, Sang Bae Jeon, Bok Yang Pyun
Clin Exp Pediatr. 1985;28(6):597-603.   Published online June 30, 1985
We observed a case of congenital nonspherocytic hemolytic anemia who was a 24 month old boy with the signs of jaundice 技 pallor. Evidences of the same disease was also found in the patient' s elder brother & father. We diagnosed these cases by history & physical examination, peripheral & B.M. blood smears, osmotic fragility test, autohemolysis test and etc. A...
One Case of Erythroleukemia.
Sang Bae Chen, Tae Sook Kim, Bok Yang Pyun
Clin Exp Pediatr. 1984;27(9):924-929.   Published online September 30, 1984
A Condition characterized Ijy a generalized malignant proliferation of the nucleated red blood cells resembling leukemia was first recognized as a clinical and pathological entity by Di Guglielmo in 1923. We experienced a case of erythroleukemia, who had suffered from abdominal distension for 5 month and multiple ecchymosis on lower extremities. Peripheral blood smear and bone marrow examination revealed proliferation...
Original Article
A Clinical Observation of Anemia in Children.
Tae Sook Kim, Sang Bae Jeon, Bok Yang Pyun
Clin Exp Pediatr. 1984;27(8):772-777.   Published online August 31, 1984
We have observed clinically about 161 cases of anemia among 251 patients who were admitted to Y.D.P.C.H. The results were obtained as follows: 1)The incidence of anemia among total admitted patients (251) was 64.1% (161 cases). These were grouped into mild & moderate anemia(58.2%) and severe anemia (5.9%) on the base of hemoglobin level. 2)The sex ratio was aproximatly 1.5 : 1...
Case Report
A Case of Lacunar Skull.
Eun Hee Koh, Bok Yang Pyun, Dong Whan Lee, Sang Man Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1982;25(3):300-304.   Published online March 31, 1982
A case of lacunar skull associated with meningomyelocele, spina bifida, kyphcsis on thoracolumbar area, hydrocephalus, bilateral club foot and paralysis of lower extremities at birth was reported. Diagnosis was made by X-ray of skull, whole spine, upper and lower extremities. On skull X-ray film, multiple small area of round rarefaction surrounded by arborizing pattern of bony ridge was visualized on...
Original Article
Clinical Obseervation of 12 cases of Kawasaki Disease.
Bok Yang Pyun, Chang Woo Koh, Dong Whan Lee, Sang Jhoo Lee
Clin Exp Pediatr. 1981;24(3):245-256.   Published online March 15, 1981
Kawasaki Disease of Mucocutaneous Lymph Node Syndrome, first described by Kawasaki in 1967, is an acute febrile disease of unknown etiology. Until recently, more than 17,000 cases of this disease have been listed in the survey of a special study group supported by the Japanese Ministry of Health and Welfare. And a number of cases have been reported even outside...
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