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Original Article
Allergy
Asthma predictive index as a useful diagnostic tool in preschool children: a cross-sectional study in Korea
Dong Hyeon Lee, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Hyo-Bin Kim, So-Yeon Lee, Gwang-Cheon Jang, Dae-Jin Song, Woo Kyung Kim, Young-Ho Jung, Soo-Jong Hong, Jung Yeon Shim
Clin Exp Pediatr. 2020;63(3):104-109.   Published online November 8, 2019
Question: Is physician-diagnosed current asthma in preschool children associated with the asthma predictive index, atopic sensitization, or pulmonary function test?
Finding: Physician-diagnosed current asthma in preschool children was associated with the asthma predictive index, but not with spirometry, methacholine provocation test, fractional expiratory nitric oxide level, and atopic sensitization.
Meaning: Physician-diagnosed asthma in preschool children may be different from classic atopic asthma in school children or adolescents.
Clinical risk factors associated with the development of wheezing in children less than 2 years of age who required hospitalization for viral lower respiratory tract infections
Joon Hwan Kim, Ji-Yeon Choi, Na Yeon Kim, Jin Woo Kim, Ji Hyeon Baek, Hye Sung Baek, Jung Won Yoon, Hye Mi Jee, Sun Hee Choi, Hyeung Yoon Kim, Ki Eun Kim, Youn Ho Shin, Man Yong Han
Clin Exp Pediatr. 2015;58(7):245-250.   Published online July 22, 2015
Purpose

Wheezing following viral lower respiratory tract infections (LRTIs) in children <2 years of age is an important risk factor for the development of asthma later in life; however, not all children with viral LRTIs develop wheezing. This study investigated risk factors for the development of wheezing during viral LRTIs requiring hospitalization.

Methods

The study included 142 children <2 years of age hospitalized...

Review Article
Association of wheezing phenotypes with fractional exhaled nitric oxide in children
Jung Yeon Shim
Clin Exp Pediatr. 2014;57(5):211-216.   Published online May 31, 2014

Asthma comprises a heterogeneous group of disorders characterized by airway inflammation, airway obstruction, and airway hyperresponsiveness (AHR). Airway inflammation, which induces AHR and recurrence of asthma, is the main pathophysiology of asthma. The fractional exhaled nitric oxide (FeNO) level is a noninvasive, reproducible measurement of eosinophilic airway inflammation that is easy to perform in young children. As airway inflammation precedes...

Early childhood wheezing: various natural courses and their relationship to later asthma
Dong In Suh, Young Yull Koh
Clin Exp Pediatr. 2012;55(8):259-264.   Published online August 23, 2012

Wheezing is one of the most frequent complaints that lead to the use of medical resources in younger children. Generally, wheezing is caused by bronchiolitis and resolves spontaneously without recurrence, but sometimes, wheezing can progress into asthma. Early data on the natural history of childhood wheezing was mostly obtained from retrospective reviews of medical records or from questionnaires, which made...

Original Article
Relationship between cord blood level of IL-12 in preterm newborns and development of wheezing
Hyo Jung Yu, Eun Ae Park, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye Sook Park, Eun Hee Ha
Clin Exp Pediatr. 2008;51(7):754-759.   Published online July 15, 2008
Purpose : Abnormal activation patterns of Th1/Th2-cells have been suggested to increase the prevalence of allergic diseases. Prevention is regarded as an important corner stone in the management of allergic diseases. In this study, we have investigated the relationship between cord blood levels of IL-4, IL-10, and IL-12 in preterm newborns and the development of allergic respiratory diseases in infancy Methods...
Increased vascular endothelial growth factor in children with acute Mycoplasma pneumoniae pneumonia and wheezing
Young Seo, Byung Keun Yu, Yeon Joung Oh, Yoon Lee, Young Yoo, Ji Tae Choung, Young Yull Koh
Clin Exp Pediatr. 2008;51(5):487-491.   Published online May 15, 2008
Purpose : Although Mycoplasma pneumoniae (M. pneumoniae) infection can cause wheezing in non-asthmatic children, the mechanisms of this symptom remain unclear. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and vascular permeability, and is also known to be elevated in cases of chronic pulmonary disease such as asthma. We hypothesized that VEGF may increase in children with...
Bronchial Hyperresponsiveness and Atopy in 6-8 Year Old Children According to the History of Wheezing in Early Childhood
Jinho Yu, Young Yoo, Hee Kang, Young Yull Koh
Clin Exp Pediatr. 2004;47(8):873-878.   Published online August 15, 2004
Purpose : It is becoming generally recognized that wheezing in early childhood is a heterogeneous condition and does not always develop into asthma. This study aimed to determine characteristics of wheezing phenotypes in early childhood and investigate their relation to asthma. Methods : Two hundreds and sixty 6-8 year old children with past or present wheezeing were enrolled, and their history...
Bronchoalveolar Cellularity and IL-8 Levels in Patients with Post-measles Wheezing
Da Eun Jung, Byeong Eui Kim, Ju Young Chung, Jeong Yeon Kim, Sang Hyuk Ma, Chang Keun Kim
Clin Exp Pediatr. 2003;46(8):763-768.   Published online August 15, 2003
Purpose : This study was conducted to investigate the pulmonary cellular profiles and IL-8 levels in patients with post-measles wheezing. Methods : Twelve previously healthy infants with a minimum of three episodes of wheezing after measles pneumonia(Measles wheezing, median age, 1.3 years) were recruited by a retrospective examination of hospital records. They underwent bronchoalveolar lavage(BAL) with flexible bronchoscopy, and high-resolution computed...
Comparison of Eosinophil Markers between Acute and Recovery Stages in Children with Mycoplasma pneumoniae Pneumonia
Kyu Min Nah, Eun Kyeong Kang, Hee Kang, Yang Park, Young Yull Koh
Clin Exp Pediatr. 2002;45(10):1227-1233.   Published online October 15, 2002
Purpose : Several studies have shown that increases of eosinophil markers are common findings of asthma and Mycoplasma pneumoniae infection, and eosinophil markers reflect the clinical stage of asthma. The purpose of this study was to investigate the change of eosinophil markers according to the clinical stage of Mycoplasma pneumonia. Methods : The patient group consisted of 33 outpatient children with Mycoplasma pneumonia. Peripheral blood...
Characteristics of Childhood Asthma According to the Onset of Wheezing
Yoon Jeong Kim, Bong Seong Kim, Soo-Jong Hong
Clin Exp Pediatr. 2000;43(5):686-693.   Published online May 15, 2000
Purpose : To understand the characteristics of early childhood asthma, we evaluated and compared the characteristics between early persistent wheezers and late wheezers. Methods : From January, 1998 to December, 1998, 106 children aged six to seven years were divided into three groups according to the onset of wheezing : Early persistent wheezers(n=36) who had wheezing both before three years of...
The Relation of Food-Specific IgE to Recurrent Wheezing Attack
Yun Jeong Yang, Jeong Hee Kim, Yoo Mee Choi, Dae Hyun Lim, Sei Woo Chung, Jeong Gyu Kim, Byong Kwan Son
Clin Exp Pediatr. 1999;42(8):1056-1062.   Published online August 15, 1999
Purpose : There were some reports that IgE-mediated food hypersensitivity is associated with subsequent development of atopic disease in wheezy infants. So we carried out this study to show whether the food specific IgE antibodies are useful to predict recurrent wheezing attack in wheezy infants. Methods : A total of 190 children younger than 4-year-old were enrolled in this study. They...
Breast Feeding and Lower Respiratory Tract Illness in the First Year of Life
Jung Ja Jun, Soo Am Jung, Ghee Am Jung, Du Bong Lee
Clin Exp Pediatr. 1994;37(6):816-821.   Published online June 15, 1994
Breast feeding is one of many factors that have been asociated with the development of lower respiratory tract illnesses. To assess the relation between breast feeding and subsequent experience of lower respiratory tract illness, we performed this study, retrospectively, on 366 infants who had been admitted to the pediatric ward, St. Francisco General Hospital, or had been brought to the...
A Clinical Study on Wheezing of Mycoplasma Pneumoniae Pneumonia in Children
Jeong Eun Kwon, Jun Ho Yoon, Jae Ook Lee, Im Ju Kang
Clin Exp Pediatr. 1993;36(10):1366-1374.   Published online October 15, 1993
The relationship between respiratory infections and exacerbations of wheezing in patients with wheezy bronchitis or asthma has been described. Most respiratory infections were viral or Mycoplasma pneumoniae. This study was performed to evaluate the effect of Mycoplasma pneumoniae infection on bronchial reactivity and atopic background. 106 patients with Mycoplasma pneumoniae pneumonia who were admitted to the department of pediatrics, Fatima Hospital,...
Clinical Observation on Acute Bronchiolitis and Recurrent Wheezing.
Chung Ghi Kim, Soon Kook Choi, Jong Duck Kim, Bock Keun Kee
Clin Exp Pediatr. 1987;30(12):1378-1386.   Published online December 31, 1987
We have compared recurrent wheezing group with non-recurrent wheezing group of 91 cases on the aspects of clinical and laboratory findings, were admitted to the Department of Pediatrics, Won Kwang University Hospital with the impression of acute bronchiolitis from Jan. 1983 to Feb. 1986 The results were as follows; 1) The incidence of recurrent wheezing was 28.6%. 2) Sex incidence of recurrent wheezing was high in male....
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