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Original Article
Neonatology (Perinatology)
Perinatal outcome and possible vertical transmission of coronavirus disease 2019: experience from North India
Ritu Sharma, Shikha Seth, Rakhee Sharma, Sanju Yadav, Pinky Mishra, Sujaya Mukhopadhyay
Clin Exp Pediatr. 2021;64(5):239-246.   Published online February 16, 2021
Question: Is there any risk of vertical transmission of coronavirus disease 2019 (COVID-19), and what is its neonatal profile?
Finding: Biological samples for vertical transmission were negative in all deliveries; however, 2 neonates tested positive for nasopharyngeal COVID-19 reverse transcription-polymerase chain reaction. No significant neonatal morbidity was observed.
Meaning: COVID-19 does not increase adverse neonatal outcomes and shows a negligible risk of vertical transmission; however, horizontal transmission cannot be underestimated.
Ten years of experience in the prevention of mother-to-child human immunodeficiency virus transmission in a university teaching hospital
Jung-Weon Park, Tae-Whan Yang, Yun-Kyung Kim, Byung-Min Choi, Hai-Joong Kim, Dae-Won Park
Clin Exp Pediatr. 2014;57(3):117-124.   Published online March 31, 2014

Administration of antiretroviral drugs to mothers and infants significantly decreases mother-to-child human immunodeficiency virus (HIV) transmission; cesarean sections and discouraging breastfeeding further decreases this risk. The present study confirmed the HIV status of babies born to mothers infected with HIV and describes the characteristics of babies and mothers who received preventive treatment.


This study retrospectively analyzed medical records of nine infants...

Case Report
An Infant with Vertical Transmission of Human Immunodeficiency Virus Infection Detected Due to Failure to Thrive
Byung Wook Eun, Ho Kyung Lim, Yun Kyung Kim, Yuong Ho Kwak, Jung Youn Hong, He Sun Jung, Kyung Mo Kim, Hoan Jong Lee
Clin Exp Pediatr. 2001;44(5):592-596.   Published online May 15, 2001
Five to fifteen percent of patients affected by human immunodeficiency virus(HIV) are children in developing countries. In Korea, most of HIV infections in children have been transfusion-related, and cases of vertical transmission have been very rare so far and are usually suspected due to a maternal positive history. We experienced a case of vertical transmission of HIV in a 19...
Original Article
Mutations in Hepatitis B Virus Precore and Core Promotor in Children with Chronic Hepatitis B Infection - Comparison Between Vertical and Non-vertical Transmission -
Jin Kuk Kim, Yeong Hong Park, Woo Yeong Chung, Chul Ho Kim
Clin Exp Pediatr. 2000;43(6):779-791.   Published online June 15, 2000
Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 46 children with chronic hepatitis B infection were analyzed by direct sequencing of polymerase chain reaction product of HBV DNA. In this study, the patients were divided...
Immune Responses and Efficacy of Hepatitis B Vaccine in Neonates Born from Hepatitis B Carrier Mothers : Focus on HBV-DNA
Jong-Hyun Kim, Jin-Han Kang, Chang-Kyu Oh
Clin Exp Pediatr. 1998;41(11):1498-1508.   Published online November 15, 1998
Purpose : The aim of this study was to elucidate the pathogenesis of vertical transmission of hepatitis B virus(HBV), and to study the protective efficacy of the vaccine and hepatitis B immune globulin(HBIG). Methods : Eighty-two infants born from HBV carrier mothers were studied. HBV plasma-derived vaccine and HBIG were administered to their neonates. Then, changes of viral markers, anti-preS2...
Vertical Transmission of Hepatitis C Virus in Infant of the Mother Who Had Active Hepatitis C during Pregnancy
Mi-Jeong Lee, Mi-Jeong Lee
Clin Exp Pediatr. 1995;38(6):857-862.   Published online June 15, 1995
Vertical transmission of hepatitis C virus(HCV) has been reported recently. The authors experienced one case of vertical transmission of HCV in infant of the mother who had active hepatitis C durig pregnancy. At delivery, HCV RNA(+), IgG anti HCV Ab(+), IgM anti HCV Ab(+), mile elevation of liver aminotransferase level and mile fatty liver of ultrasonography were found in the...
Original Article
A case of primary hepatocellular carcinoma following vertical transmission of hepatitis B virus in a child.
Soo Kyoung Lee, Ki Sup Chung, Sun Won Hong, Chan Il Park
Clin Exp Pediatr. 1991;34(11):1573-1580.   Published online November 30, 1991
Authors experienced a case of primary hepatocellular carcinoma in a 7 year 9 month old male patient, who was admitted to our hospital due to abdominal pain on right upper quadrant and anorexia during last two months. On family history, his mother was HBs Ag and HBe Ag carrier. On past history, he was admitted to a hospital due to persistant jaundice at...
The Effect of Hepatitis B Vaccination on Newborns of Hepatitis B Carrier Mothers.
Ho Taek Kom, Pyung Kil Kim, Chang Ho Hong, Chul Lee
Clin Exp Pediatr. 1987;30(11):1228-1235.   Published online November 30, 1987
The transmission of hepatitis B virus (HBV) from carrier mothers to their infants is a serious problem in many countries and the transmission rate is reported to be as high as 60%. The best preventive method of perinatal transmission is hepatitis B immune globulin (HBIG) which confers a passive immunity and HB vaccine which confers an active immunity. However, the exact dosage and the...
Case Report
A Case of Chronic Active Hepatitis with Vertical Transmission.
T H Son, T S Song, H J Park, M J Shin, J G Chi
Clin Exp Pediatr. 1984;27(2):164-169.   Published online February 28, 1984
We experienced a case of Chronic Active Hepatitis with vertical transmission in a 4-year-3-month old boy. Diagnosis of CAH was confirmed by histologic features of liver biopsy. The mode of infection in this case was suspected as vertical transmission by clinical history. His mother had acute hepatitis B in the last trimester of the pregnancy of this boy and had...
Original Article
A Survey of HBs Antigenemia Among Healthy Primary and Middle Children, Pregnant Women in Kyungpook Province.
G H Jun, J J Kim, D H Shin, S D Yoon
Clin Exp Pediatr. 1983;26(12):1188-1195.   Published online December 31, 1983
The prevalence of hepatitis B surface antigen in various regions of the world is estimated to range from 0.1% low to 15% high. The area with high prevalence is the west pacific region. The carrier rate of hepatitis B surface antigen among 897 healthy primary and middle school children in Taegu City, Korea was investigated in November, 1982. Another sample of 729...
Case Report
A Case of Vertically Transmitted Neonatal Hepatitis B with Pancytopenia.
Young Chang Kim, Jae Oak Park
Clin Exp Pediatr. 1982;25(7):737-742.   Published online July 31, 1982
A newborn infant, who was low-birth weight(1,780gm), showed severe degree of jaundice on second day of life and skin color became dark greenish-yellow and moderate hepatosplenomegaly was noted on physical examination. Results of liver function test & radioimmuniassay for hepatitis B antigen of both infant and mother suggested that neonatal hepatitis B seemed to occure transplacentally during pregnancy from infected...
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