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Review Article
Oncology
Update on infantile hemangioma
Hye Lim Jung
Clin Exp Pediatr. 2021;64(11):559-572.   Published online May 26, 2021
· Infantile hemangiomas (IHs) are the most common benign vascular tumors, occurring in 5%–10% of infants.
· IHs are characteristically not present at birth but are usually diagnosed at 1–4 weeks of age, rapidly proliferate until 5 months of age, and then spontaneously involute.
· High-risk IHs (10%) require early treatment from 1 month of age.
· Oral propranolol, a nonselective beta-blocker, is the first-line treatment for IHs.
Adolescence Medicine
The impacts of exercise on pediatric obesity
Ronald J. Headid III, Song-Young Park
Clin Exp Pediatr. 2021;64(5):196-207.   Published online August 4, 2020
Pediatric obesity contributes to the development of vascular dysfunction and metabolic and cardiovascular diseases which have all been shown to track into adulthood, increasing the risk of early mortality. Early exercise intervention is critical for combating obesity-related comorbidities and the optimal exercise prescription has yet to be well documented. Exercise prescriptions to combat pediatric obesity should incorporate both aerobic and muscle-strengthening exercises with an emphasis on long-term adherence.
Original Article
Alagille syndrome and a JAG1 mutation: 41 cases of experience at a single center
Kyung Jin Ahn, Ja Kyoung Yoon, Gi Beom Kim, Bo Sang Kwon, Jung Min Go, Jin Su Moon, Eun Jung Bae, Chung Il Noh
Clin Exp Pediatr. 2015;58(10):392-397.   Published online October 21, 2015
Purpose

Alagille syndrome is a complex hereditary disorder that is associated with cardiac, hepatic, skeletal, ocular, and facial abnormalities. Mutations in the Notch signaling pathway, such as in JAG1 and NOTCH2, play a key role in embryonic development. A cardiac or hepatic presentation is a critical factor for determining the prognosis.

Methods

We conducted a retrospective study of 41 patients with Alagille syndrome...

Cardiovascular risk factors of early atherosclerosis in school-aged children after Kawasaki disease
Hyun Jeong Cho, Soo In Yang, Kyung Hee Kim, Jee Na Kim, Hong Ryang Kil
Clin Exp Pediatr. 2014;57(5):217-221.   Published online May 31, 2014
Purpose

The aim of this study was to determine whether school-aged children with Kawasaki disease (KD) have an increased risk for early atherosclerosis.

Methods

The study included 98 children. The children were divided into the following groups: group A (n=19), KD with coronary arterial lesions that persisted or regressed; group B (n=49), KD without coronary arterial lesions; and group C (n=30), healthy children....

Development of metabolic syndrome and its correlation with insulin resistance in adult patients with Turner syndrome
Joo Hwa Kim, Min Jae Kang, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2009;52(3):370-375.   Published online March 15, 2009
Purpose : The risk of metabolic syndrome (MS) and cardiovascular disease in Turner syndrome (TS) patients is high. We analyzed metabolic factors in adults with TS and evaluated the metabolic risk of insulin resistance. Methods : Forty-three adults with TS were enrolled. The frequency of MS and the values of the metabolic factors were analyzed. Patients were divided into insulin...
Review Article
Pediatric cerebrovascular disease
Ji Hoon Phi, Kyu-Chang Wang, Byung-Kyu Cho, Seung-Ki Kim
Clin Exp Pediatr. 2008;51(12):1282-1289.   Published online December 15, 2008
Recently, accumulated clinical experience and advanced neuroradiological techniques have led to a better understanding of pediatric cerebrovascular disease (CVD), which was once considered rare. Approximately 10% of pediatric neurosurgical patients have CVD; therefore, it is no longer uncommon to pediatricians and pediatric neurosurgeons. Furthermore, children with CVD tend to recover better than adults after stroke because the immature brain is...
Original Article
Pulse wave velocity and ankle brachial index in obese adolescents
Ji Hye Kim, Hee Sun Koo, Young Mi Hong
Clin Exp Pediatr. 2007;50(11):1078-1084.   Published online November 15, 2007
Purpose : The prevalence of childhood obesity has doubled over the last 30 years. Obesity-associated sequelae in the vasculature begins in the early stages of life. The purpose of this study was to investigate how pulse wave velocity (PWV) and ankle brachial index (ABI) change with height, weight and body mass index (BMI) in obese adolescents. Methods : Seventy-nine obese...
Airway Compression or Airway Anomaly Causing Respiratory Symptoms in Infants and Children with Cardiovascular Diseases
Ja-Hyeong Kim, So-Yeon Lee, Hyo-Bin Kim, So-Eun Koo, Sung-Jong Park, Young-Hui Kim, In-Suk Park, Jae-Kon Ko, Dong-Man Seo, Soo-Jong Hong
Clin Exp Pediatr. 2005;48(7):737-744.   Published online July 15, 2005
Purpose : Infants and children with cardiovascular diseases often present with respiratory symptoms. However, missed or delayed evaluation for potential airway problem may complicate overall prognosis. The aim of this study is to determine the clinical characteristics of these patients and explore the cause of airway problem. Methods : We reviewed the medical records of 64 patients(M : F=33:31, mean...
Clinical Evaluation and Diagnosis of Children with Chest Pain
Su A Shin, Yong Joo Kim, Jae Whan Lee, Nam Su Kim, Soo Ji Moon
Clin Exp Pediatr. 2003;46(12):1248-1252.   Published online December 15, 2003
Purpose : Chest pain in the pediatric population is not rare and mostly benign. Causes of chest pain are diverse, and differential diagnosis is not easy. Chest pain in children is less likely to be cardiac in origin. Furthermore, chest pain in the pediatric population is rarely associated with life-threatening disease. This study was designed to evaluate children with chest...
Diagnostic Method of Congenital Cardiovascular Diseases Using Spiral Computed Tomography and Three Dimensional Reconstruction
Hye Kyung Lee
Clin Exp Pediatr. 1998;41(10):1389-1396.   Published online October 15, 1998
Purpose : One of the new methods for diagnosing congenital cardiovascular diseases is the spiral CT and three-dimensional image reconstruction. The spiral CT allows continuous data collection while the subject is advanced through the CT gantry, it provides an uninterrupted volume of data that can be reconstructed to produce a three-dimensional representation of CT information and also this method has...
Clinical Characteristics of Cerebrovascular Disease in Infants and Children and Its Outcomes
Young Jae Song, Tae Gyu Hwang, Soo Chun Kim
Clin Exp Pediatr. 1996;39(2):246-254.   Published online February 15, 1996
Purpose : The incidence and clinical features of cerebrovascular disease in childhood were not clearly clarified in domestic. This study was undertaken to evaluate the clinical characteristics of cerebrovascular disease in infants and children, and its outcome, a retrospective study was performed to adequate management. Methods : We reviewed clinical records of the patients who had admitted to Inje University Pusan...
Clinical Characteristics of Childhood Cerebrovascular Disease and Analysis on the Prognostic Factors
Yong Seung Hwang, Moon Sun Yang
Clin Exp Pediatr. 1995;38(3):353-365.   Published online March 15, 1995
Purpose : Cerebrovascular disease in children is more common than was once recognized and the etiology and prognosis of the disease in children are quite different from those of adults. Recently according to medical reports and clinical experiences, the incidence of childhood cerebrovascular disease is increasing in Korea. To clarify the clinical features of childhood cerebrovascular disease and to analyze its...
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