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Original Article
Infection
Usefulness of interferon-γ release assay for the diagnosis of latent tuberculosis infection in young children
Ki Wook Yun, Young Kwang Kim, Hae Ryun Kim, Mi Kyung Lee, In Seok Lim
Clin Exp Pediatr. 2016;59(6):256-261.   Published online June 30, 2016
Purpose

Latent tuberculosis infection (LTBI) in young children may progress to severe active tuberculosis (TB) disease and serve as a reservoir for future transmission of TB disease. There are limited data on interferon-γ release assay (IGRA) performance in young children, which our research aims to address by investigating the usefulness of IGRA for the diagnosis of LTBI.

Methods

We performed a tuberculin skin...

Review Article
Treatment of latent tuberculous infection in children and adolescent
Jong-Hyun Kim
Clin Exp Pediatr. 2009;52(5):519-528.   Published online May 15, 2009
Tuberculosis continues to cause an unacceptably high toll of disease and death among children worldwide. Whereas intense scientific and clinical research efforts into novel diagnostic, therapeutic, and preventive interventions have focused on tuberculosis in adults, childhood tuberculosis has been relatively neglected. However, children are particularly vulnerable to severe disease and death following infection, and those with latent infection become the...
Original Article
Comparison of a whole blood Interferon-γ assay and A tuberculin skin test for detecting latent tuberculosis infection in children
Jin-Kyong Chun, Jin-Kyong Chun, Chang Ki Kim, Chang Ki Kim, Hyun Sook Kim, Hyun Sook Kim, Ghee Young Jung, Ghee Young Jung, John A. Linton, John A. Linton, Ki Hwan Kim, Ki Hwan Kim, Taek Jin Lee, Taek Jin Lee, Ji Hyun Jeon, Ji Hyun Jeon, Dong Soo Kim, Dong Soo Kim
Clin Exp Pediatr. 2008;51(9):971-976.   Published online September 15, 2008
Purpose : Surveillance for detecting and managing latent tuberculosis infection (LTBI) is a key component of tuberculosis control. The classic surveillance tool, the tuberculin skin test (TST), may have some limitations when used in the Bacillus Calmette-Guérin (BCG)-vaccinated population. The object was to perform a blood test QuantiFERON®-TB Gold In Tube (QFT-G IT) based on the detection of interferon-γ (IFN-γ)...
Association between Tuberculin Responses and Serum IgE
Pil Ju Jeong, Yong Dae Ham, Jin Hwa Jeong, Jeong Ho Lee
Clin Exp Pediatr. 2000;43(4):502-505.   Published online April 15, 2000
Purpose : Atopy is a state of allergic response, mediated by IgE, to common environmental allergens. In recent decades, there has been an increase in prevalence of atopic disorders in children in developed countries. The factor associated with the rise of atopy incidence may be declining exposure to some infection opportunities. The aim of this study is to determine if...
Tuberculin Skin Test and Measles Vaccination
Mi Sung Chung, Young Mi Kim, Hyung Ja Park, Shinna Kim
Clin Exp Pediatr. 1993;36(4):537-542.   Published online April 15, 1993
Although the incidence of tuberculosis in Korea in general has declined in recent years, it remains an important health problem, especially in children. Inspite of the recent controversy over the necessity of tuberculin skin test prior to measles vaccination, this brief report shows 13.8% of positive skin test at 9 and 15 months of age at the time of measles...
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