Clinical and Experimental Pediatrics

Original Article

Critical Care Medicine

Effect of postoperative enteral protein supplementation on nitrogen balance in critically ill children

Irene Yuniar, Kadek Apik Lestari, Antonius Hocky Pudjiadi, Fatima Safira Alatas, Yoga Devaera

Clin Exp Pediatr. 2025;68(10):790-800. Published online May 30, 2025

Question: Does high-protein enteral nutrition better increase the average nitrogen balance (NB) and decrease the intestinal fatty acid-binding protein (I-FABP) level of critically ill postoperative children than standard-protein enteral nutrition?
Finding: The study demonstrated a significant increase in average NB but no significant decrease in I-FABP levels in the high- versus low-protein group.
Meaning: These findings suggest that high-protein enteral nutrition can improve NB in critically ill postoperative children, thereby supporting their recovery.

DOI: https://doi.org/10.3345/cep.2025.00227

Pulmonology

Effect of vitamin C supplement in treatment of childhood pneumonia requiring hospitalization: a randomized controlled trial

Chutima Phuaksaman, Katechan Jampachaisri, Klaita Srisingh

Clin Exp Pediatr. 2025;68(9):690-699. Published online April 1, 2025

Web of Science 1 Crossref 1

This study assessed the effects of vitamin C on children with community-acquired pneumonia (CAP). Vitamin C supplementation improved clinical symptoms within 48–72 hours compared to placebo but did not reduce the length of hospital stay (LOS). These findings suggest that vitamin C is beneficial for managing CAP severity, but does not affect LOS.

DOI: https://doi.org/10.3345/cep.2025.01970

Developmental and Behavioral Medicine

Effect of omega-3 plus methylphenidate as an alternative therapy to reduce attention deficit-hyperactivity disorder in children

Soleiman Mohammadzadeh, Narmin Baghi, Fayegh Yousefi, Bahar Yousefzamani

Clin Exp Pediatr. 2019;62(9):360-366. Published online May 20, 2019

Crossref 14

Background: Attention deficit-hyperactivity disorder (ADHD) is one of the most common chronic behavioral disorders in school-aged children.
Purpose: This study aimed to evaluate the effect of omega-3 supplementation as an alternative therapy for ADHD, which can be caused by vitamin and mineral deficiencies. Methods: This was a double-blinded clinical trial study. Sixty-six children with ADHD (aged 6–12 years) referred to our child...

DOI: https://doi.org/10.3345/kjp.2018.06982

Relactation in the Lactation Clinic

Su Jin Cho, Keun Lee

Clin Exp Pediatr. 2005;48(10):1050-1054. Published online October 15, 2005

Purpose : Relactation refers to the re-establishment of a milk supply and nursing after the cessation of nursing for a variable period. We aimed to analyze the practical issues related to successful relactation in the lactation clinic. Methods : The medical records of 51 mothers who had visited the lactation clinic for relactation were retrospectively analyzed. Breastfeeding greater than 90%...

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Changes in GFAP Immunoreactivity of Astrocytes in Rats with Reye's Syndrome Induced by Valproic Acid and the Effects of Carnitine Supplementation

Young-Yoo Kim, Kyung-Tai Whang

Clin Exp Pediatr. 1999;42(7):966-979. Published online July 15, 1999

Purpose : This study was designed to investigate whether valproic acid(VPA) induces Reye's syndrome by analyzing blood chemistry, carnitine(CARN) concentration, and the morphologic changes of hepatocytes. The changes of GFAP immunoreactivity of astrocytes were examined in rats with Reye's syndrome induced by VPA. And the effects of CARN supplementation on Reye's syndrome were also investigated. Methods : Ten rats were assigned...

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