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Successful pleurodesis with OK-432 in preterm infants with persistent pleural effusion

Jeong Eun Kim, Chul Lee, Kook In Park, Min Soo Park, Ran Namgung, In Kyu Park

Clin Exp Pediatr. 2012;55(5):177-180. Published online May 21, 2012

OK-432 (picibanil) is an inactivated preparation of Streptococcus pyogenes that causes pleurodesis by inducing a strong inflammatory response. Intrapleural instillation of OK-432 has recently been used to successfully treat neonatal and fetal chylothorax. Here we report a trial of intrapleural instillation of OK-432 in two preterm infants who were born with hydrops fetalis and massive bilateral pleural effusion. Both cases...

DOI: https://doi.org/10.3345/kjp.2012.55.5.177

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