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Purpose : In order to determine the effect of neuronal nitric oxide synthase(nNOS) in seizure-related
neuronal vulnerability of the hippocampus, the expression patterns of nNOS were examined
in pentylenetetrazole(PTZ)-induced seizure groups and in PTZ seizure groups which were pretreated
with nNOS inhibitors.
Methods : Male Sprague-Dawley rats weighing 200-300 g were used in PTZ(40 mg/kg)-induced
seizure experiments. A specific inhibitor, 50 mg/kg 7-nitroindazole(7-NI), and a... |