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- Review Article
- Infection
- Consideration in treatment decisions for refractory Mycoplasma pneumoniae pneumonia
- Hye-Kyung Cho
- Clin Exp Pediatr. 2021;64(9):459-467. Published online February 10, 2021
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• To avoid unnecessary exposure to secondary antibiotics, it is needed to diagnose Mycoplasma pneumoniae (MP) pneumonia carefully, especially when unresponsiveness to macrolide is suspected.
• Serologic and molecular tests for MP infection and excluding respiratory infection caused by other pathogens might be considered.
• It is necessary to continuously monitor antibiotic susceptibility of MP, and efforts to lower antibiotic pressure are required.
- Pulmonology
- Benefits and risks of therapeutic alternatives for macrolide resistant Mycoplasma pneumoniae pneumonia in children
- Hyeon-Jong Yang
- Clin Exp Pediatr. 2019;62(6):199-205. Published online March 15, 2019
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Although Mycoplasma pneumoniae pneumonia (MPP) has been generally susceptible to macrolides, the emergence of macrolide-resistant MPP (MRMP) has made its treatment challenging. MRMP rapidly spread after the 2000s, especially in East Asia. MRMP is more common in children and adolescents than in adults, which is likely related to the frequent use of macrolides for treating M. pneumoniae infections in children....
- Mechanism of resistance acquisition and treatment of macrolide-resistant
Mycoplasma pneumoniae pneumonia in children - Hyeon-Jong Yang, Dae Jin Song, Jung Yeon Shim
- Clin Exp Pediatr. 2017;60(6):167-174. Published online June 22, 2017
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Mycoplasma pneumoniae pneumonia (MPP) is one of the most common forms of community-acquired pneumonia in children and adolescents. Outbreaks of MPP occur in 3- to 7-year cycles worldwide; recent epidemics in Korea occurred in 2006–2007, 2011, and 2015–2016. Although MPP is known to be a mild, self-limiting disease with a good response to macrolides, it can also progress into a...
- Original Article
- Pulmonology
- Prevalence and clinical manifestations of macrolide resistant
Mycoplasma pneumoniae pneumonia in Korean children - Eun Lee, Hyun-Ju Cho, Soo-Jong Hong, Jina Lee, Heungsup Sung, Jinho Yu
- Clin Exp Pediatr. 2017;60(5):151-157. Published online May 31, 2017
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Purpose Macrolide resistance rate of
Mycoplasma pneumoniae has rapidly increased in children. Studies on the clinical features between macrolide susceptible-M. pneumoniae (MSMP) and macrolide resistant-M. pneumoniae (MRMP) are lacking. The aim of this study was to identify the macrolide resistance rate ofM. pneumoniae in Korean children withM. pneumoniae penupmonia in 2015 and compare manifestations between MSMP and MRMP.Methods Among 122...
- Case Report
- Neurology
- Complete occlusion of the right middle cerebral artery associated with
Mycoplasma pneumoniae pneumonia - Ben Kang, Dong Hyun Kim, Young Jin Hong, Byong Kwan Son, Myung Kwan Lim, Yon Ho Choe, Young Se Kwon
- Clin Exp Pediatr. 2016;59(3):149-152. Published online March 31, 2016
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We report a case of a 5-year-old girl who developed left hemiparesis and left facial palsy, 6 days after the initiation of fever and respiratory symptoms due to pneumonia. Chest radiography, conducted upon admission, showed pneumonic infiltration and pleural effusion in the left lung field. Brain magnetic resonance imaging showed acute ischemic infarction in the right middle cerebral artery territory....
- Original Article
- Hepatitis associated with
Mycoplasma pneumoniae infection in Korean children: a prospective study - Kyu Won Kim, Jae Jin Sung, Hann Tchah, Eell Ryoo, Hye Kyung Cho, Yong Han Sun, Kang Ho Cho, Dong Woo Son, In Sang Jeon, Yun Mi Kim
- Clin Exp Pediatr. 2015;58(6):211-217. Published online June 22, 2015
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Purpose Mycoplasma pneumoniae (MP) infection is a major cause of respiratory infection in school-aged children. Extrapulmonary manifestations of MP infection are common, but liver involvement has been rarely reported. The aim of this study was to determine the clinical characteristics of MP-associated hepatitis.Methods This prospective study included 1,044 pediatric patients with MP infection diagnosed serologically with MP IgM at one medical center...
- Predictive value of C-reactive protein in response to macrolides in children with macrolide-resistant
Mycoplasma pneumoniae pneumonia - Young Ho Seo, Jang Su Kim, Sung Chul Seo, Won Hee Seo, Young Yoo, Dae Jin Song, Ji Tae Choung
- Clin Exp Pediatr. 2014;57(4):186-192. Published online April 30, 2014
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Purpose The prevalence of macrolide-resistant
Mycoplasma pneumoniae (MRMP) has increased worldwide. The aim of this study was to estimate the proportion of MRMP in a tertiary hospital in Korea, and to find potential laboratory markers that could be used to predict the efficacy of macrolides in children with MRMP pneumonia.Methods A total of 95 patients with
M. pneumoniae pneumonia were enrolled in...
- Case Report
Mycoplasma pneumoniae associated stroke in a 3-year-old girl- Gun-Ha Kim, Won Hee Seo, Bo-Kyung Je, So-Hee Eun
- Clin Exp Pediatr. 2013;56(9):411-415. Published online September 30, 2013
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Infectious diseases precede a significant proportion of acute ischemic strokes in children. Here, we report a case of acute ischemic stroke in a 3-year-old girl with a
Mycoplasma pneumonia -associated respiratory tract infection. She developed an acquired prothrombotic state of protein S deficiency and had increased fibrinogen and fibrinogen degradation product levels and increased titer of antinuclear antibodies. However, these conditions...
- Original Article
- Detection of genetic mutations associated with macrolide resistance of Mycoplasma pneumoniae
- Chi Eun Oh, Eun Hwa Choi, Hoan Jong Lee
- Clin Exp Pediatr. 2010;53(2):178-183. Published online February 15, 2010
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Purpose : The aim of this study was to identify mutations associated with macrolide resistance in Mycoplasma pneumoniae (MP) and to establish a cultural method to determine antimicrobial susceptibility. Methods : Nasopharyngeal aspirates (NPAs) were collected from 62 children diagnosed with MP pneumonia by a serologic method or polymerase chain reaction. The 23S rRNA and L4 ribosomal protein genes of MP... -
- Clinical significance of codetection of the causative agents for acute respiratory tract infection in hospitalized children
- Eui Jung Roh, Young Pyo Chang, Jae Kyung Kim, In Soo Rheem, Kwi Sung Park, Eun Hee Chung
- Clin Exp Pediatr. 2009;52(6):661-666. Published online June 15, 2009
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Purpose : To determine the prevalence and clinical features of codetected respiratory etiological agents for acute respiratory infection in hospitalized children. Methods : Nasopharyngeal aspirates were obtained from hospitalized children with acute respiratory infection at Dankook University Hospital from September 2003 through June 2005. Immunofluorescent staining and culture were used for the detection of respiratory viruses (influenza virus [IFV] types... -
- Mycoplasma pneumoniae pneumonia in Korean children, from 1979 to 2006-a meta-analysis
- Jin Woo Kim, Hyun Kyong Seo, Eun Gyong Yoo, Sung Jin Park, So Hwa Yoon, Hye Young Jung, Manyong Han
- Clin Exp Pediatr. 2009;52(3):315-323. Published online March 15, 2009
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Purpose : This study aimed to perform a systematic review of the reports on Mycoplasma pneumoniae pneumonia in the last 30 years (1980-2006) to investigate the intervals between outbreaks, change in the peak incidence age, and diagnostic methods. We also aimed to validate the proper diagnostic criteria for M. pneumoniae pneumonia. Methods : We reviewed 62 original articles on M. pneumoniae... -
- Case Report
- Atypical presentation of Kawasaki disease resembling a retropharyngeal abscess
- Sun-Hee Choi, Yu-Min Lee, Yeong-Ho Rha
- Clin Exp Pediatr. 2009;52(2):247-250. Published online February 15, 2009
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Stevens-Johnson syndrome (SJS) presents with widespread blisters, erythematous or purpuric macules, and one or more mucous membrane erosions. Various etiologic factors, including infection, vaccination, drug administration, systemic diseases, physical agents, and food have been implicated as causes of SJS. Mycoplasma pneumoniae is the most common infectious agent to cause SJS in children. In recent literature, M. pneumoniae-induced SJS with mucositis... -
- Two cases of central nervous system complications caused by Mycoplasma pneumoniae infection
- Shin Mi Kim, Ji Seung Heo, Eun Jung Shim, Dae Hyoung Lee, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo
- Clin Exp Pediatr. 2008;51(5):533-537. Published online May 15, 2008
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Mycoplasma pneumoniae (M. pneumoniae) infection causes a wide variety of clinical manifestations in children and young adults, the main one being pneumonia. M. pneumoniae is transmitted from person to person by infected respiratory droplets. Symptoms caused by M. pneumoniae infection can be divided into those involving the respiratory tract, and those caused by extrapulmonary disease. M. pneumoniae infections may cause... -
- Original Article
- Increased vascular endothelial growth factor in children with acute Mycoplasma pneumoniae pneumonia and wheezing
- Young Seo, Byung Keun Yu, Yeon Joung Oh, Yoon Lee, Young Yoo, Ji Tae Choung, Young Yull Koh
- Clin Exp Pediatr. 2008;51(5):487-491. Published online May 15, 2008
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Purpose : Although Mycoplasma pneumoniae (M. pneumoniae) infection can cause wheezing in non-asthmatic children, the mechanisms of this symptom remain unclear. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and vascular permeability, and is also known to be elevated in cases of chronic pulmonary disease such as asthma. We hypothesized that VEGF may increase in children with... -
- Clinical Findings of Mycoplasma Pneumonia in Children, from 1998 to 2003
- Ji-Hyun Kim, Soo Ahn Chae, Dong-Keun Lee
- Clin Exp Pediatr. 2005;48(9):969-975. Published online September 15, 2005
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Department of Pediatrics, College of Medicine, Chung Ang University, Seoul, Korea Purpose : We performed a study of clinical findings of Mycoplasma Pneumonia in children, to know differences between recent clinical manifestations of Mycoplasma pneumonia and previous studies. Methods : The subjects of this study were 393 children who were diagnosed as Mycoplasma pneumonia with high titers of Mycoplasma antibody(≥1 : 160)... -
- Hepatitis Complicated with Mycoplasma pneumoniae Infection in Children
- Seung Min Lee, Sung Moon Lee, Hann Tchah, In Sang Jeon, Eell Ryoo, Kang Ho Cho, Yong Han Seon, Dong Woo Son, Hee Joo Hong
- Clin Exp Pediatr. 2005;48(8):832-838. Published online August 15, 2005
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Purpose : Mycoplasma pneumoniae infection is relatively common in childhood. Its extrapulmonary manifestations have been reported so much, but hepatitis associated with it has been reported rarely in Korea. Methods : A clinical study was performed on 556 patients of M. pneumoniae pneumonia diagnosed serologically at Gil hospital from January 2001 to December 2004. We reviewed 65 cases among these patients,... -
- A Study of Antibody Conversion Rate During a Mycoplasma pneumoniae Epidemic Period(the Second Half of 2003)
- Do Kyun Kim, Young Yoo, Jinho Yu, Young Yull Koh
- Clin Exp Pediatr. 2005;48(5):500-505. Published online May 15, 2005
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Purpose : This study was designed to estimate the prevalence of Mycoplasma pneumoniae infection during an epidemic period by means of examining the antibody conversion rate and to investigate the association of the antibody conversion with age, initial antibody titer, and atopy. Methods : We chose 191 children whose antibody titer to M. pneumoniae was negative, 1 : 40, or... -
- Study of Exchange Phenomenon of Mycoplasma pneumoniae in Children from 1997-2002
- Sung Seok Kim, Hoon Kang, Byung Moon Ahn, Won Wook Lee, Eun Ryoung Kim, Soo Yeon Kim, Hyun Pil Cho
- Clin Exp Pediatr. 2004;47(1):24-30. Published online January 15, 2004
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Methods : We enrolled 504 patients out of 547 patients, who were admitted to the Department of Pediatrics, Sung-Ae and Kwangmyung Sung-Ae General Hospital from November 1996 to October 2002. They were diagnosed as M. pneumoniae pneumonia by clinical characteristics and indirect particle agglutination test of M. pneumoniae. To classify into two groups, the group specific polymerase chain reaction amplification... -
- Pattern of Occurrence of Mycoplasma pneumoniae Pneumonia in Admitted Children : Southern Central Korea, from 1989 to 2002
- Ki Su Kang, Hyang-Ok Woo
- Clin Exp Pediatr. 2003;46(5):474-479. Published online May 15, 2003
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Purpose : The determination of exposure and prevalence of Mycoplasma pneumoniae pneumonia of any region should be helpful for clinical diagnosis. We studied the pattern of occurrence of M. pneumoniae pneumonia among children living in southern central Korea during the last 13 years. This area has a relatively small population and less mobility compared with metropolitan areas. Methods : We performed... -
- Comparison of Eosinophil Markers between Acute and Recovery Stages in Children with Mycoplasma pneumoniae Pneumonia
- Kyu Min Nah, Eun Kyeong Kang, Hee Kang, Yang Park, Young Yull Koh
- Clin Exp Pediatr. 2002;45(10):1227-1233. Published online October 15, 2002
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Purpose : Several studies have shown that increases of eosinophil markers are common findings of asthma and Mycoplasma pneumoniae infection, and eosinophil markers reflect the clinical stage of asthma. The purpose of this study was to investigate the change of eosinophil markers according to the clinical stage of Mycoplasma pneumonia. Methods : The patient group consisted of 33 outpatient children with Mycoplasma pneumonia. Peripheral blood... -
- Case Report
- A Case of Cerebral Infarction Complicated by Mycoplasma pneumoniae Pneumonia
- Kyoung Whoon Cheon, Won Sik Kang, Byeong Hee Son, Sung Won Kim
- Clin Exp Pediatr. 2002;45(5):673-678. Published online May 15, 2002
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Mycoplasma pneumoniae is the most common pathogen of the respiratory tract among school- aged children and young adults. The incidence of CNS complication is reported as 0.1-7% of Mycoplasma pneumoniae infections. We experienced a case of cerebral infarction complicated by Mycoplasma pneumoniae, and reviewed the literature about the CNS complication of Mycoplasma pneumoniae infection. -
- A Case of Bilateral Spontaneous Tension Pneumothorax Associated with Mycoplasma pneumoniae Infection
- Jae Won Lee, Mi Young Heo, Hae Soon Kim, Seung Joo Lee
- Clin Exp Pediatr. 2002;45(3):401-405. Published online March 15, 2002
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Mycoplasma pneumoniae(M. pneumoniae) is the leading cause of pneumonia in school-age children and young adults. The clinical courses are usually mild but recently, severe cases were reported such as lung abscess, Swyer-James syndrome and adult respiratory distress syndrome. Spontaneous pneumothorax associated with M. pneumoniae infection is rare. Carlisle reported a 6-year-old patient with bilateral spontaneous pneumothorax associated with M. pneumoniae... -
- Original Article
- Clinical Significance of Serum ECP in Mycoplasma Pneumoniae Pneumonia
- Young Ghil Rah, Dong Keun Lee, In Seok Lim, Eung Sang Choi, Soo Ahn Chae
- Clin Exp Pediatr. 1999;42(5):672-678. Published online May 15, 1999
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Purpose : Allergic inflammation of the lower respiratory tract is a characteristic clinical feature in asthma patients, in which eosinophils play an important role. The activity of eosinophil may be determined by measuring the level of eosinophil cationic protein(ECP) in sputum or serum as a potential marker of the inflammatory severity. Methods : We measured the serum concentrations of ECP... -
- Clinical Utility of the Sputum Polymerase Chain Reaction Obtained by Nebulizer in the Diagnosis of Mycoplasma pneumoniae Pneumonia
- Kye Nam Yoon, Sang Wook Park, Eui Ho Lee, Won Bae Lee, Kyung Tai Whang, Hee Jin Lee
- Clin Exp Pediatr. 1999;42(3):348-354. Published online March 15, 1999
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Purpose : The polymerase chain reaction(PCR) has been used for the early diagnosis of mycoplasmal infections using various clinical samples. In this study, the clinical utility of sputum PCR through a new method was studied to diagnose mycoplasma pneumonia. Methods : One hundred nineteen pneumonic patients, ages ranging from 15 months old to 15 years old, were examined from Aug, 1997... -
- Significance of Polymerase Chain Reaction Test for Diagnosis of Mycoplasma pneumoniae Pneumonia
- Hae-kyung Lim, Young-Hun Chung
- Clin Exp Pediatr. 1999;42(2):173-179. Published online February 15, 1999
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Purpose : Mycoplasma pneumoniae is a common cause of lower respiratory disease, especially in children and young adults. The diagnosis, in most cases, is confirmed by serology. M. pneumoniae is difficult to culture because of its fastidious nature, and growth is too slow for diagnostic use. In this prospective study, the sensitivity and specificity of the PCR assay was evaluated... -
- Relationship between Chest Radiography and Cell-mediated Immunity in Mycoplasma pneumoniae Pneumonia
- Yong Dae Ham, Jae Il Yoo, Jin Hwa Jeong, Jeong Ho Lee, Jong Dae Cho
- Clin Exp Pediatr. 1998;41(11):1509-1516. Published online November 15, 1998
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Purpose : Mycoplasma pneumoniae pneumonias have been one of the most common causes of lower respiratory tract diseases during childhood. It is suggested that pathologic changes seen in the lung tissues were the histologic expression of the host immune response. The aim of this study was to determine the relationship between the chest radiographic pattern of Mycoplasma pneumoniae pneumonia and... -
- The Diagnostic Value of Polymerase Chain Reaction in Mycoplasma pneumoniae Pneumonia
- Han Wook Kang, Byung Moon Ahn, Moo Young Song, Eun Ryoung Kim, Suk Ho Choi, Il Soo Kim
- Clin Exp Pediatr. 1998;41(10):1351-1358. Published online October 15, 1998
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Purpose : This study was performed to evaluate the polymerase chain reaction(PCR) in the diagnosis of Mycoplasma pneumoniae pneumonia in comparison with the specific antibody test. Methods : Five hundred and ten patients with pneumonia, ranging from the ages of 8 months to 15 years who were admitted in Sung-Ae and Kwangmyung Sung-Ae general hospitals from Nov. 1996 to Oct.... -
- Study of Seroprevalence of Antimycoplasma Antibody in Healthy Children and its Diagnostic Value
- Soo Kyung Choi, Ji Ah Jung, Kyung Hyo Kim, Gyoung Hee Kim
- Clin Exp Pediatr. 1998;41(4):489-497. Published online April 15, 1998
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Purpose : To evaluate the diagnostic reliability of the single serum titers of the specific serum antibody determiantion method, we compared antimycoplasma antibody titers of 177 healthy children with 353 children who had respiratory symptoms indicative of Mycoplasma pneumoniae infection. Methods : We used Serodia-Myco II particle agglutination test and the titers of ≥1:40 were regarded as positive. Results : Age distribution of 177 healthy... -
- Efficacy of Mycoplasma Antibody Test and Cold Agglutinin Test in the Diagnosis of Mycoplasma Pneumonia in Children
- Jung Ae Son, Weon Par, Dong Jin Lee
- Clin Exp Pediatr. 1998;41(2):179-185. Published online February 15, 1998
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Purpose : This study was done to compare the diagnostic value of the Mycoplasma antibody (M- Ab) test and the cold agglutinin(CA) test from the onset of Mycoplasma pneumoniae pneumonia to its diagnosis in children. Methods : We analyzed 48 cases of M. pneumoniae pneumonia in children who were admitted to the Pediatric Department of Ulsan Dongkang General Hospital for 1... -
- Occurrence of Mycoplasma pneumoniae Pneumonia in Seoul, Korea, from 1986 to 1995
- Jung-Yun Hong, Song-Yi Nah, Seung-Gon Nam, Eun-Hwa Choi, Jin-Young Park, Hoan-Jong Lee
- Clin Exp Pediatr. 1997;40(5):607-613. Published online May 15, 1997
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Impact Factor4.2
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6.52022CiteScore92nd percentilePowered by
