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Original Article

Matrix Metalloproteinases, Tissue Inhibitors and Cytokines in Patients with Kawasaki Disease

Ae Ra Cho, Young Mi Hong

Clin Exp Pediatr. 2004;47(6):656-664. Published online June 15, 2004

Purpose : Kawasaki disease(KD) is a multisystemic inflammatory vasculitis of unknown etiology, but immunological abnormalities have been documented and implicated in the pathogenesis of KD. Matrix metalloproteinases(MMPs) have proteolytic activity against connective tissue proteins, and increased activity of MMPs and a quantitative imbalance between MMP and tissue inhibitor of MMP (TIMP) can result in several pathologic conditions. MMP and TIMP...

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