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Original Article
Oncology
Excellent treatment outcomes in children younger than 18 months with stage 4 MYCN nonamplified neuroblastoma
Chiwoo Kim, Young Bae Choi, Ji Won Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
Clin Exp Pediatr. 2018;61(2):53-58.   Published online February 28, 2018
Purpose

Although the prognosis is generally good in patients with intermediate-risk neuroblastoma, no consensus has been reached on the ideal treatment regimen. This study analyzed treatment outcomes and toxicities in patients younger than 18 months with stage 4 MYCN nonamplified neuroblastoma.

Methods

We retrospectively analyzed 20 patients younger than 18 months newly diagnosed with stage 4 MYCN nonamplified neuroblastoma between January 2009 and...

Case Report
Oncology
Relapsed Wilms' tumor with multiple brain metastasis
Akın Akakın, Baran Yılmaz, Murat Şakir Ekşi, Özlem Yapıcıer, Türker Kılıç
Clin Exp Pediatr. 2016;59(Suppl 1):S96-S98.   Published online November 30, 2016

Wilms' tumor is the most common malignant renal tumor in childhood. The brain metastasis of a Wilms' tumor with anaplastic histopathology is rare. We present the case of an 8-year-old girl with Wilms' tumor, who presented with multiple brain metastases 5 years after her primary diagnosis. The brain masses were diagnosed after a generalized tonic-clonic seizure attack. The big solid...

Development of multifocal nodular lesions of a liver mimicking hepatic metastasis, following resection of an insulinoma in a child
Sook Young Jung, Ben Kang, Yoon Mee Choi, Jun Mee Kim, Soon Ki Kim, Young Se Kwon, Ji Eun Lee
Clin Exp Pediatr. 2015;58(2):69-72.   Published online February 28, 2015

Insulinoma, which arises from insulin-producing pancreatic beta cells, is a rare tumor in children. Only 5%-10% of insulinomas are malignant and undergo metastasis. We report a case of an 11-year-old girl who experienced hypoglycemia-related seizures induced by an insulinoma; after resection of the primary tumor, she developed hepatic focal nodular hyperplasia (FNH). Laboratory test results indicated marked hypoglycemia with hyperinsulinemia....

A fatal case of acute pulmonary embolism caused by right ventricular masses of acute lymphoblastic lymphoma-leukemia in a 13 year old girl
Yu Mi Ko, Soo Hyun Lee, June Huh, Hong Hoe Koo, Ji Hyuk Yang
Clin Exp Pediatr. 2012;55(7):249-253.   Published online July 17, 2012

We report a case of a 13-year-old girl with acute lymphoblastic lymphoma-leukemia, who presented with a cardiac metastasis in the right ventricle, resulting in a pulmonary embolism. At the time of her leukemia diagnosis, a cardiac mass was incidentally found. The differential diagnosis for this unusual cardiac mass included cardiac tumor, metastasis, vegetation, and thrombus. Empirical treatment was initiated, including...

Original Article
Pulmonary tuberculosis misdiagnosed as lung Metastasis in childhood cancer patients
Hyun Rae KK, Dong Whand Lim, Kang Min, Kyung Duk Park, Jun Ah Lee, Soo Yeon Cho, Yoon Hoh Kook, Hee Youn Kim, Dong Ho Kim
Clin Exp Pediatr. 2009;52(8):904-909.   Published online August 15, 2009

Purpose:The differential diagnosis for a pulmonary nodule is intriguing in cancer patients. Metastasis might be a preferential diagnosis, and yet possibilities of other medical conditions still exist. Pulmonary tuberculosis should be enlisted in the differential diagnosis for a pulmonary nodule in cancer patients in Korea. This study was aimed at analyzing the incidence and clinical features of pulmonary tuberculosis that were misdiagnosed as...
Case Report
A case of recurrent hepatoblastoma : lung, heart and brain metastasis
Sun Mi Park, Byung Kyu Choe, Yeo Hyang Kim, Heung Sik Kim, Tae Chan Kwon, Hee Jung Lee
Clin Exp Pediatr. 2006;49(6):691-695.   Published online June 15, 2006
Hepatoblastoma is a hepatic tumor predominantly occurring in children. The usual site of metastasis is the lung. There are only several reports worldwide on the distant metastasis of hepatoblastoma to the central nervous system in children. Only one reported case showed survival of a patient after multiple resections of a recurrent brain lesion. Involvement of the cardiovascular system has been...
Original Article
Anti-angiogenesis and Anti-metastasis Characteristics of the Novel Tumor Suppressor Gene PTEN
Pyoung Han Hwang, Ho Keun Yi, Myoung Hee Han, Dae Yeol Lee, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2001;44(6):654-663.   Published online June 15, 2001
Purpose : The tumor suppressor gene PTEN/MMAC1 is mutated in a variety of advanced and metastatic cancers, strongly suggesting that PTEN/MMAC1 alterations may be involved in tumor progression and the formation of metastases. However, the roles of PTEN in tumor growth and metastasis and its functional mechanisms are not fully understood. We evaluated the tumor suppressor function of PTEN/MMAC1 gene...
Case Report
Departments of Neurosurgery, Gyeongsang National University, College of Medicine, Chinju, Korea
Jae Young Lim, Young Kyu Park, Eun Sang Kim, Dong Wook Kim
Clin Exp Pediatr. 1997;40(4):555-558.   Published online April 15, 1997
Spinal-cord astrocytomas are rare, comprising only 1% of all primary central nervous system tumors. Malignant astrocytomas grade III and IV account for only 7.5% of intramedullary spinal gliomas occurring in all age groups and for as few as 1.2% of primary intramedullary tumors in children. The frequency of primary intramedullary with intracranial metastasis is relatively rare in childhood and such...
Three Cases of Brain Tumors with Bone Metastasis
Eun Joo Kim, Kyung Duk Park, Eun Sil Dong, Hye Jung Park, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Je Geun Chi
Clin Exp Pediatr. 1992;35(3):381-389.   Published online March 15, 1992
Medulloblastoma and primitive neuroectodermal tumor(PNET) are relatively common intracranial neoplasms in childhood. Their extracranial metastasis were thought to be rare occurrences. But they are more frequent compared to other intracranial tumors. The most frequent site of metastasis deposits in medulloblastoma is bone, and metastasis to lymph node, peritoneum, liver or lung have been reported infrequently. The authors experienced three cases...
Original Article
A case of metastatic neuroblastoma to brain.
Sang Wook Choi, Mee Jeong Lee
Clin Exp Pediatr. 1991;34(5):715-719.   Published online May 31, 1991
Metastatic neuroblastoma to whole bones and brain generally has been considered incurable, but some reports have been published with good and partial response after initial chemotherapy followed by second-look operation. But the long term survival is dismal. Recently we experienced a case of metastatic neuroblastoma to brain without neurologic symptoms confirmed by computed tomograpy, who had multiple bony metastases including skull. The whole metastatic...
A Case of Adrenal Cortical Carcinoma.
Ho Won Kang, Hong Ja Kang, Hong Bae Kim, Ji Sub Oh
Clin Exp Pediatr. 1990;33(8):1159-1165.   Published online August 31, 1990
This is a case report of adrenal cortical carcinoma in a 2 year 7 month old male patient who was diagnosed by clinical features, endocrinologic studies, radiologic studies and pathologic examina- tions. Cushing syndrome and virilization caused by adrenal cortical carcinoma were found. Left total adrenalectomy was performed. No evidence of metastasis was found at the time of operation. 3 months later, lung metastases...
A Case of Pancreatoblastoma with Metastasis of the Liver.
Dae Sung Oh, Yong Won Paik, Jae Sun Park, Kyung Hyun Choi, Man Ha Huh
Clin Exp Pediatr. 1990;33(5):684-689.   Published online May 31, 1990
We experenced a case of pancreatoblastoma in a 6 years old Korean male who was admmited to the pediatric department because of an abdominal mass and pathologically diagnosed following surgical removal. Microscopically, the resected mass was composed of small sized tumor cells arranged in glandular or acini structure with multifoci of squamoid corpuscle. Extensive hemorrhagic necrosis was another feature. Ultrastructucturally, two types of cells, dark...
Case Report
Four Cases of Papillary Thyroid Cancer in Childhood.
Sei Weon Yang, Sei Won Park, In Sil Lee, Hyo Seup Ahn, Hyung Ro Moon, Chang Yee Hong, Kwi Won Park, Je Geun Chi
Clin Exp Pediatr. 1984;27(3):282-287.   Published online March 31, 1984
Papaillary thyroid cancer is a rare lesion in children. It progresses slowly and its prognosis is relatively good. A painless nodule in the thyroid or in the neck is the usual first evidence of disease. Cervical lymph node involvement is usually present at the time of the initial diagnosis and is often bilateral. The lungs are the most common site...
A Case of Lung Metastasis of Testicular Yolk Sac Tumor.
Ho Ju Yoon, Hyun Kyung Cho, Jung Sik Chun, Chang Kyu Oh, Mahn Kyoo Yang
Clin Exp Pediatr. 1982;25(12):1275-1279.   Published online December 31, 1982
First admission; A 4 year old male patient was admitted with progressive swelling and tenderness of left scrotum since birth. Left simple orchiectomy was performed. The histolo- gic finding was testicular yolk sac tumor. Second admission; 2 years later. The patient was readmitted with migrating pain and limitation of motion of lower extremities. Lung metastasis (LLL extending to lingular lobe) was appeared. During chemotherapy, he...