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Case Report
A case of Kikuchi-Fujimoto disease with autoimmune thyroiditis
Eun Ji Go, You Jin Jung, Seung Beom Han, Byung Kyu Suh, Jin Han Kang
Clin Exp Pediatr. 2012;55(11):445-448.   Published online November 23, 2012

Kikuchi-Fujimoto disease (KFD) is a benign self-limiting disease characterized by fever and lymphadenitis. The etiology and pathogenesis of KFD is unclear. However, two hypotheses have been suggested: a viral infection hypothesis and an autoimmune hypothesis. Several KFD patients with various types of autoimmune diseases have been reported, and these reports support the hypothesis for autoimmune pathogenesis of KFD. Here, we...

Original Article
Needle aspiration as therapeutic management for suppurative cervical lymphadenitis in children
Mee Young Baek, Kyung Hee Park, Ju Hee We, Su Eun Park
Clin Exp Pediatr. 2010;53(8):801-804.   Published online August 31, 2010
Purpose

This study aimed to evaluate the usefulness of the needle aspiration alternative to open surgical drainage of children with suppurative cervical lymphadenitis requiring surgical drainage.

Methods

From January 1998 to June 2008, we retrospectively reviewed 38 children treated with needle aspiration as management with suppurative cervical lymphadenitis instead of open surgical drainage.

Results

All 38 children underwent only 1 puncture. Two patients (5.2%) out...

Toll-like receptor 2 expression on monocytes from patients with BCG vaccine-associated suppurative lymphadenitis
Hyun Joo Oh, Kyung-Sue Shin
Clin Exp Pediatr. 2009;52(6):667-673.   Published online June 15, 2009
Purpose : Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections. The purpose of this study was to analyze TLR2 surface expressions and TLR2-mediated tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) production in patients with BCG vaccine-associated suppurative lymphadenitis. Methods : Peripheral monocytes were separated from 16 patients with BCG vaccine-associated suppurative lymphadenitis and 10 healthy...
Case Report
Kikuchi-Fujimoto disease with aseptic meningitis
Se Jin Park, Won Jin Moon, Wan Seop Kim, Kyo Sun Kim
Clin Exp Pediatr. 2009;52(5):622-626.   Published online May 15, 2009
Kikuchi-Fujimoto disease was initially described as a self-limiting histiocytic necrotizing lymphadenitis in Japan in 1972, and is predominantly observed in women under the age of 30 year and in Asian populations. The pathogenesis is still poorly understood but is thought to include infections, and autoimmune and neoplastic diseases. The most common clinical manifestations are fever and painless cervical lymphadenitis. Diagnosis...
Original Article
Analysis of disease mechanism of subacute necrotizing lymphadenitis in children
Hyun Jung Kim, Jung Suk Yeom, Ji Suk Park, Eun Sil Park, Ji Hyun Seo, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Jae Min Cho, Jeong Hee Lee, Hee Shang Youn
Clin Exp Pediatr. 2008;51(11):1198-1204.   Published online November 15, 2008
Purpose : The cause of subacute necrotizing lymphadenitis, a rare disease in children, has not been completely clarified. This study was aimed to investigate the disease mechanism by examining clinical, radiologic, and immunohistochemical findings in children diagnosed with subacute necrotizing lymphadenitis after an excisional biopsy. Methods : We examined 19 lymph node tissue specimens from 17 children diagnosed with subacute...
Detection of HHV6 and EBV in histiocytic necrotizing lymphadenitis
Kyung Hee Park, Sung Shik Park, Ji Yeon Kim, Su Eun Park
Clin Exp Pediatr. 2008;51(9):987-991.   Published online September 15, 2008
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis (HNL), is a self-limited disease characterized by cervical lymphadenopathy and fever. The etiology of KFD remains unknown; however, the self-limiting nature of HNL suggests the cause of this disease could be viral infection. For this reason, several viruses have been evaluated as possible etiologies of HNL, including Epstein-Barr virus (EBV), human...
Histiocytic necrotizing lymphadenitis in children : association of human herpes virus 8 and Epstein Barr virus
Hyun A Kim, Ju-Young Chung, Sang Woo Kim, Sung Jig Lim, Haeng Seop Shin
Clin Exp Pediatr. 2006;49(8):875-881.   Published online August 15, 2006
Purpose : The aims of this study were to analyze the clinical characteristics of children with Kikuchi's disease(KD) at a medical center and to investigate the etiologic role of human herpesvirus 8(HHV 8) or Epstein-Barr virus(EBV) in children with KD. Methods : Twenty six children who were diagnosed as KD between Jan. 1998 and Dec. 2005 were included....
Case Report
A case of Kikuchi's disease with skin involvement
Ji Min Jang, Chul Hee Woo, Jung Woo Choi, Dae Jin Song, Young Yoo, Kwang Chul Lee, Chang Sung Son
Clin Exp Pediatr. 2006;49(1):103-106.   Published online January 15, 2006
Histiocytic necrotizing lymphadenitis, which is also commonly referred to as Kikuchi's disease (KD), is a self-limiting disease of unknown etiology. It affects individuals of all ages, although it is usually seen in young women. However, only a few descriptions of this disease are available in the pediatric literature. KD is clinically characterized by cervical lymphadenopathy, high fever, myalgia, neutropenia and,...
Original Article
Lymphadenitis following intradermal BCG vaccination
Hey Sung Baek, Ji Young Chang, Su Ji Moon, Sung Hee Oh
Clin Exp Pediatr. 2006;49(1):46-50.   Published online January 15, 2006
Purpose : Intradermal BCG vaccine has not well been accepted by pediatric practitioners due to BCG lymphadenitis. Therefore, this study was undertaken to find out the incidence of lymphadenitis following intradermal BCG vaccination and its clinical outcome. Methods : One thousand and fifty infants, who received intradermal BCG(French 1173 P2, Korea Tuberculosis Association) vaccination in the Well Baby Clinic of Hanyang...
The effect of local rifampicin instillation on the treatment of suppurative BCG lymphadenitis
Min Son Kim, Dae Sun Jo, Kang Mi Kyung, Sang Jae Kim, Jung Soo Kim
Clin Exp Pediatr. 2006;49(1):40-45.   Published online January 15, 2006
Purpose : The purpose of this study was to evaluate the types of lymphadenitis after BCG vaccination and the effect of local rifampicin instillation on the treatment of suppurative BCG lymphadenitis. Methods : A total of 32 otherwise healthy infants with suppurative BCG lymphadenitis, who visited the Department of Pediatrics of Chonbuk National University Hospital, from March 2002 through June 2004,...
Case Report
A Case of Kikuchi-Fujimoto Disease, Subsequently Evolving to Systemic Lupus Eyrthematosus
Soon Hwa Yoon, Myoung Hoon Song, Seon Hee Shin, Sung Koo Kim, Kon Hee Lee, Hae Sun Yoon, Young Ok Jung, Hye Kyung Ahn
Clin Exp Pediatr. 2004;47(8):904-907.   Published online August 15, 2004
Kikuchi-Fujimoto disease(KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limited systemic illness and it has the pathognomonic histological appearance of lymph nodes. KFD is rarely associated with systemic lupus erythematosus (SLE). The diagnosis of KFD can precede, postdate or coincide with the diagnosis of SLE. Our case describes a young woman, originally diagnosed as having Kikuchi's disease by lymph...
Original Article
Is Acute Nonspecific Mesenteric Lymphadenitis Associated with Acute Abdominal Pain in Epidemic Aseptic Meningitis?
Hae Rim Kim, Kiyoung Ku, Young Hwan Lee, Sin Kam, Jin-Bok Hwang
Clin Exp Pediatr. 2004;47(6):623-627.   Published online June 15, 2004
Purpose : Acute abdominal pain in an epidemic aseptic meningitis which is mostly an enterovirus as causative agent, is noted in 23-55% of patients. An enterovirus is also known as one of the causes of acute nonspecific mesenteric lymphadenitis(ANML). The purpose of this study was to see if ANML was associated with acute abdominal pain in epidemic aseptic meningitis. Methods :...
Clinical Observation of Mesenteric Lymphadenitis in Children
Chul Han Park, Dong Hoon Lee, Hye Lim Kim, Ji Min Park, Jin Bok Hwang, Heung Sik Kim, Hee Jung Lee
Clin Exp Pediatr. 2004;47(1):31-35.   Published online January 15, 2004
Purpose : Mesenteric lymphadenitis is classified into acute and chronic, specific and nonspecific types according to clinical aspect and causative disease. We under took this study to find out clinical aspects, associated diseases and hospital course of mesenteric lymphadenitis in children. Methods : We examined 98 children aged from 18 months to 14 years who visited Dongsan Medical Center for abdominal...
Clinical Features of Subacute Necrotizing Lymphadenitis in Children
Ji Young Hong, Sun Hwan Bae, Wan Sup Kim
Clin Exp Pediatr. 2002;45(8):994-999.   Published online August 15, 2002
Purpose : There is a predilection for subacute necrotizing lymphadenitis(SNL) in young Asian women. Few pediatric cases have been reported. This study was performed to evaluate clinical features of children with SNL. Methods : We retrospectively analyzed clinical features of 23 cases of SNL under 15 years of age identified in Nowon Eulji Hospital from February 1995 to January 2002. Two...
Local Rifampicin Instillation Therapy for Suppurative Bacillus Calmette-Gu rin Lymphadenitis
Mee Jeong Kim, Seong Hee Jang, Young Min Ahn, Mi Kyoung Kang, Sang Jae Kim
Clin Exp Pediatr. 2002;45(4):454-458.   Published online April 15, 2002
Purpose : Bacillus Calmette-Gu rin(BCG) lymphadenitis is one of the most common complications of BCG vaccination. The involved lymph nodes usually subside spontaneously, but they may become enlarged and form an abscess. Treatment of these infants is controversial. The Pan American Health Organization recommends local isoniazid or rifampicin instillation for patients with suppurative BCG lymphadenitis. Methods : The study group comprised...
Case Report
A Recurred Case of Subacute Necrotizing Lymphadenitis(Kikuchi`s Disease) During Childhood
Jin Sun Park, Chang Hee Oh, Je Woo Kim, Phil Soo Oh, Young Ah Lee, He Sun Yun, Jung Weon Shim
Clin Exp Pediatr. 2000;43(9):1285-1289.   Published online September 15, 2000
Subacute necrotizing lymphadenitis, or Kikuchi`s disease, primarily affects the cervical lymph nodes of young adults and has a self-limited clinical course. Differential diagnoses are malignant lymphoma and systemic lupus erythematosus. Recurrence rate is low as 3.3%, and there have been a few reports describing the recurrence of the disease. The symptoms in almost all recurrent cases were similar to those...
Three Cases of Subacute Necrotizing Lymphadenitis in Childhood
Min Hyang Park, Jin A Son, Jae Wook Go, Jae Yoon Kim, Don Hee Ahn
Clin Exp Pediatr. 2000;43(3):423-427.   Published online March 15, 2000
Subacute necrotizing lymphadenitis was first reported by Kikuchi and Fujimoto in 1972. Young females no more than 30 years of age are mainly affected. It usually manifests as fever and cervical lymphadenopathy. We experienced three cases of subacute necrotizing lymphadenitis in an 11-year-old boy, a 12- year-old boy and an 11-year-old girl. Symptoms presented were URI signs, diarrhea, headache and...
The Lymphocyte Subset Change in a Case of Subacute Necrotizing Lymphadenitis
Ji Hyang Doh, Sung Taek Kim, Kyeong Shin Lee, So Young Jeong
Clin Exp Pediatr. 1998;41(7):994-1000.   Published online July 15, 1998
The subacute necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease, is a benign, self-limited disorder of unknown cause. This rare disease is characterized by fever, lymphadenopathy, leukopenia, and elevated sedimentation rate. This disease preferentially affects young women. The diagnosis of this disease is confirmed by involved lymphnodes biopsy. Evidence for autoimmune dysfunction has been reported, but is usually lacking. According to...
Original Article
A Clinical Study on BCG Lymphadenitis
Jin Soo Hwang, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
Clin Exp Pediatr. 1997;40(5):614-619.   Published online May 15, 1997
Purpose : We studied the incidence and clinical course of BCG lymphadenitis to investigate the BCG related problem. Subject and Methods: Three hundred and eighty-six infants received BCG vaccine (Pasteur-1173p2) in the Well Baby Clinic, Dept. of Pediatrics, Chonnam University Hospital from May 1993 and April 1994. Among them, twenty three infants developed regional lymphadenitis. We investigated the clinical course...
Case Report
Subacute Necrotizing Lymphadenitis in a 3 Year-Old Male Child
You Mee Heo, Seong Koo Kim, Young Ah Lee, Dae Gil Lee, Ha Ju Choi, Woo Kap Chung, Jung Won Shin
Clin Exp Pediatr. 1996;39(10):1443-1447.   Published online October 15, 1996
Subacute necrotizing lymphadenitis is a benign form of lymphadenitis that was first described in Japan by Kikuchi in 1972. It mainly affects young women and usually manifests as fever and lymphadenopathy. Although it is a benign self-limited lymphadenitis, it has been misdiagnosed as malignant lymphoma. Histologically, involved lymph nodes contain a necrotizing process characterized by patch, well-circumscribed area with eosinophilic fibrinoid material. There is...
Original Article
Clinical Investigation of Neck Masses in Children
Sung Chul Byun, Dong Soo Kim
Clin Exp Pediatr. 1996;39(10):1429-1442.   Published online October 15, 1996
Purpose : Neck masses are frequently encountered in pediatric practice, and have various underlying diseases. If the underlying diseases of the neck mass are not confirmed by its clinical characteristics, it can be done by neck mass biopsy. To define the necessity and the appropriate time of neck mass biopsy is very difficult and also important. Therefore the authers have conducted this study to...
Case Report
Subacute Necrotizing Lymphadenitis (Kikuchi's Disease) in a Child with Atopic Asthma
Dong Jun Kim, Seong Yeoub Moon, Ha Baik Lee, Yeong Hae Koh
Clin Exp Pediatr. 1995;38(8):1141-1145.   Published online August 15, 1995
Subacute necrotizing lymphadenitis (Kikuchi's disease) is an increasingly recognized cause of cervical lymphadenitis since it has been described by Japanese doctors in 1972. It generally follows a benign course, when symptoms and signs of the disease are resolved usually within 1 to 6 months. We experienced a case of subacute necrotizing lymphadenitis in a 12 year-old boy with atopic bronchial asthma...
A Case of Tuberculous Mesenteric Lymphadenitis Clinically Presenting as Abdominal Mass
Seung Hee Mok, Soo Young Lim, Heui Jeong Kwon, In Sil Lee
Clin Exp Pediatr. 1995;38(6):872-876.   Published online June 15, 1995
Tuberculosis may affect Iymphnodes of any part of the body as a primary infection or secondary to lymphatic or hematogenous dissemination. But the diagnosis of tuberculous mesenteric lymphadenitis is often difficult to establish, because symptoms and signs are often quite vague and laboratory and radiologic findings ard unhelpful. We have recently experienced a case of tuberculous mesenteric lymphadenitis clinically presenting as...
A Case of Intestinal Tuberculosis with Tuberculous Mesenteric Lymphadenitis Simulating Neoplasm
Jin Young Choi, Won Kyu Choi, Hwang Min Kim, Joong Soo Kim
Clin Exp Pediatr. 1995;38(3):404-408.   Published online March 15, 1995
The incidence of abdominal tuberculosis is decreasing due to more effective chemotherapy and pasteurization of milk and tuberculosis may nt be given serious consideration, especially when the primary pulmonary site is healed or not roentgenographically apparent. The clinical features of these infection are relatively nonspecific and the combination of abdominal mass, weight loss, anorexia and fever frequently lead to an...
A Case of Cryptococcal Lymphadenitis
Ho Sung Cho, Young Baek Hahm, Il Sin Moon, Churl Young Chung, Jung Weon Shim, Il Huang Ko
Clin Exp Pediatr. 1992;35(1):108-112.   Published online January 15, 1992
Cryptococcosis is a subacute or chronic mycotic infection caused by Cryptococcus neoformans with a special predilection for the lung, skin, central nervous system and lymphatic system. The authors have experienced a patient with cryptococcosis involving lymphatic system only. He was cured with combination therapy of Amphotericin-B and 5-Fluorocytosine for 6 weeks. Referential literatures were reviewed.
Original Article
A case of histiocytic necrotizing lymphadenitis.
Jin Kuk Kim, Jong Bum Shin, Chul Ho Kim, Soon Yong Lee
Clin Exp Pediatr. 1991;34(4):582-586.   Published online April 30, 1991
We experienced a case of histiocytic necrotizing lymphadenitis in a 10-year old male child with complaints of high fever and painful swelling on right cervical area for 11 days. The diagnosis was based on histopathologic findings of right cervical lymph node, clinical features and laboratory findings. A review of literatures was also presented briefly.
A Case of Intestinal Tuberculosis with Huge Retroperitoneal Tuberculous Lymphadenitis Simulating Neoplasm.
Yong Suk Kim, Dong Seok Choi, Keon Su Rhee, Young Hun Chung
Clin Exp Pediatr. 1988;31(10):1385-1389.   Published online October 31, 1988
Since the advent of effective antituberculous chomtherapy in the 1940s, the frequency and severity of intestinal tuberculosis have markedly decreased. But the incidence of tuberculous disease is still high in Korea. We have recently experienced a cases of intestinal tuberculosis with huge retroperitoneal tuberculous lymphadenitis simulating neoplasm in 2 year 3 month old female. The cases was reported with the brief review of literatures.
A Case of Mediastinal Tuberculous Lymphadenitis.
Hyung Ja Park, Mi Ja Yoon, Shinna Kim
Clin Exp Pediatr. 1988;31(10):1381-1384.   Published online October 31, 1988
A case of mediastinal tuberculous lymphadnitis in 5 year old male child was reported. Clinical symptoms were disappeared and chest CT findings showed very much improvement after administra- tion of Isoniazid, Rifampin and Prednisolone for 4 months. A brief review of literature was presented.
Clinical Analysis of Cervical Masses in Infants and Children.
Dae Young Hwang, Do Seung Lee, Jeung Sick Min, Jae Sun Park
Clin Exp Pediatr. 1983;26(4):366-372.   Published online April 30, 1983
Cervical masses are encountered frequently in pediatric practice. Hardly an upper respiratory infection occurs without lymphadenopathy and many of these enlarged lymph nodes persist for disturbingly long periods of time. Scattered among these innocent cervical masses are those which ultimately are found to be dangerous. Sooner or later, the persistent cervical mass becomes a problem in diagnosis and treatment.In order...
Clinical and Histopathological Studies on Superficial Lymphadenopathy in Pediatric Ages.
Chong Ock Lee, Chan Il Park, Woo Hee Jung, In Joon Choi
Clin Exp Pediatr. 1982;25(6):560-570.   Published online June 30, 1982
The superficial lymph nodes may be enlarged in consequence of biologic or non-biologic antigenic stimuli, lymphoreticular maligna ntneoplasm, metastatic tumor or infiltrative disorders such as histiocytosis-X, and biopsy of the enlarged superficial lymph node is a time-honored diagnostic, therapeutic and follow-up tool. At present it is performed with ease and wideness. But in Korea there is no comprehensive studies about...


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