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Original Article
Genetics and Metabolism
Neonatal indirect hyperbilirubinemia and glucose-6-phosphate dehydrogenase deficiency
Hasan M. Isa, Masooma S. Mohamed, Afaf M. Mohamed, Adel Abdulla, Fuad Abdulla
Clin Exp Pediatr. 2017;60(4):106-111.   Published online April 25, 2017

This study aimed to determine the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among infants with neonatal indirect hyperbilirubinemia (NIH); compare G6PD-deficient and G6PD-normal patients regarding hyperbilirubinemia and need for exchange transfusions (ET); and assess risk factors for ET and kernicterus.


This is a case-control retrospective study. Medical records of NIH patients admitted to the Pediatric Department, Salmaniya Medical Complex, Bahrain, between...

Etiology, Management, and Prognosis of Severe Hyperbilirubinemia (Serum Bilirubin Level=25 mg/dL) in Newborn
Jong Hee Hwang, Ji Hyun Lee, Yu Jin Kim, Su Hyun Koo, Jang Hun Lee, Chang Won Cho, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2005;48(10):1102-1106.   Published online October 15, 2005
Purpose : The present study examined the etiology, management, and the difference of prognosis according to methodology of treatment in severe hyperbilirubinemia with total serum bilirubin levels of more than 25 mg/dL. Methods : Medical records of severe hyperbilirubiemia in newborns(serum level=25 mg/dL) admitted to the NICU of Samsung Medical Center between October 1994 and June 2004 were reviewed retrospectively. Infants...
Near-Infrared Spectroscopy for Monitoring Cerebral Hemodynamics in Hyperbilirubinemia-induced Newborn Piglets
Jong Hee Hwang, Chang Won Choi, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2005;48(6):649-654.   Published online June 15, 2005
Purpose : The present study examined how changes in cerebral hemodynamics in newborn piglets with bilirubin infusion can be evaluated by near infrared sepctroscopy(NIRS). Methods : Seventeen newborn piglets were randomly divided into the following three experimental groups : six in the control group(CG); seven in the bilirubin infusion group(BG), and four in the bilirubin infusion with 7-nitroindazole group(NG). To...
Clinical and Follow up Study of 52 cases of Blood Exchange Transfusion for Neonatal Hyperbilirubinemia.
Hong In Eum, Jae Gae Rheu, Sang Cheol Lee, Jung Hee Lee
Clin Exp Pediatr. 1983;26(10):996-1003.   Published online October 31, 1983
The study was made of 52 cases of neonatal hyperbilirubinemia receiving blood exchange transfusion at St. Benedict Hospital from January 1977 to June 1981 with the following results; 1) 34.6% of total exchanged patients were born at St. Benedict hospital. Remains were born at outside. 2) 27 patients(51.9%) returned for follow up, 21 patients(40.4%) not returned for follow up 4 patients (7.7%) had died. 3) The...
A Follow-up Study of Newborns who had Exchange Blood Transfusion for Hyperbilirubinemia.
Young Soo Yoon, Seung Joon Park, Ki Bok Kim
Clin Exp Pediatr. 1981;24(9):826-836.   Published online September 15, 1981
A follow up study was made of 59 cases of neonatal hyperbilirubinemia receving blood exchange transfusion at Kwangju Christian Hospital from early 1976 to early 1979, with the following results. 1. 42patients(71.2%) returned for followup: 12 patients(20.3%) did not return; and 5 patients(8.5%) had died. 2. Of those returning, developmental status was studied by D.D.S.T. 38 patients(90.5%) had normal development...
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