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Review Article
Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage
So Yoon Ahn, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2014;57(6):251-256.   Published online June 30, 2014

Severe intraventricular hemorrhaging (IVH) in premature infants and subsequent posthemorrhagic hydrocephalus (PHH) causes significant mortality and life-long neurological complications, including seizures, cerebral palsy, and developmental retardation. However, there are currently no effective therapies for neonatal IVH. The pathogenesis of PHH has been mainly explained by inflammation within the subarachnoid spaces due to the hemolysis of extravasated blood after IVH. Obliterative...

Original Article
Early neurodevelopment in very low birth weight infants with mild intraventricular hemorrhage or those without intraventricular hemorrhage
Il Rak Choi, Jang Hoon Lee, Moon Sung Park, Ji Yeon Kim, Kyu Hee Park, Gun-Ha Kim, So-Hee Eun
Clin Exp Pediatr. 2012;55(11):414-419.   Published online November 23, 2012
Purpose

This study aimed to assess early development in very low birth weight (VLBW) infants with mild intraventricular hemorrhage (IVH) or those without IVH and to identify the perinatal morbidities affecting early neurodevelopmental outcome.

Methods

Bayley Scales of Infant Development-II was used for assessing neurological development in 49 infants with a birth weight <1,500 g and with low grade IVH (≤grade II) or...

Case Report
A case of intracranial hemorrhage in a neonate with congenital factor VII deficiency
Won Seok Lee, Young Sil Park
Clin Exp Pediatr. 2010;53(10):913-916.   Published online October 31, 2010

Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder. Bleeding manifestations and clinical findings vary widely, ranging from asymptomatic subjects to patients with hemorrhages that may cause significant handicaps. Treatment has traditionally involved factor VII(FVII) replacement therapy using fresh frozen plasma, prothrombin complex concentrates or plasma-derived FVII concentrates. Recombinant activated FVII (NovoSeven®) is currently considered the first-line treatment for...

Original Article
CNS Complications in Childhood Cancer
Yoo Jin Jeong, Yeon Kyong Seo, Seung Ah Hong, Heung Sik Kim, Jun Sik Kim, Hee Jung Lee
Clin Exp Pediatr. 2003;46(11):1112-1117.   Published online November 15, 2003
Purpose : Recent advances in the methods of treating cancer in young patients have led to both an increased frequency of CNS complications as well as prolonged life expectancy. We intend to analyze the clinical aspects and laboratory findings of patients with CNS complications during and after treatment. Methods : We reviewed the medical records of 174 childhood cancer...
A Clinical Study of Non-Accidental Intracranial Hemorrhage in Children
Kwon Hoe Huh, Keum Ho Song, Ki Sik Min, Ki Yang Yoo
Clin Exp Pediatr. 2003;46(11):1067-1072.   Published online November 15, 2003
Purpose : Non-accidental intracranial hemorrhage in children is not low in incidence and results in high mortality and serious sequelae. So, the authors have researched the distribution of sex and age, causes, symptoms and signs, hemorrhagic types, mortality rate and sequelae of the patients hospitalized with non-accidental intracranial hemorrhage at Hallym University Sacred Heart Hospital. Methods : The medical records of...
Intracraial Hemorrhage in Premature and Low Birth Weight Infants by Craniosonography
Seung Hee Choi, Jae Ock Park, Sang Man Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1995;38(6):752-759.   Published online June 15, 1995
Purpose : Intrabventricular hemorrhage is a common neuropathologic finding in premature and low birth weight infants. It is deeply related with neonatal death and neurologic sequelae. We want to know the incidence and the relating factors of intracranial hemorrhage in premature and low birth weight infants. Methods : We performed craniosonography in 170 premature and low birth weight infants in 3-7...
Intractranial Hemorrhage in Full-Term Neonates by Ultrasonography
Chang Gyu Lim, Joon Soo Park, Woo Ryong Lee, Jae Ock Park, Sang Mann Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1993;36(11):1570-1577.   Published online November 15, 1993
Intracranial hemorrhage is the most common neuropathologic finding in premature infants. But in full-term infants, It is less common and rarely causes death. We found out intracranial hemorrhages in 21 full-term neonates by real-time neurosonography and concluded as followings. 1) Among 21 neonates, 17 infants were male and 4 infants were female. 2) In 11(52.3%) infants the hemorrhage was detected within 7...
Intracranial hemorrhage in the prematurity and small for gestational age an attempt of clinico-ultrasonographic correlation.
Kwang Sup Kim, You Seop Shin, Jong Wan Kim, Kwang Nam Kim, Ki Yang Ryoo, Hyo Keun Lim
Clin Exp Pediatr. 1991;34(1):49-56.   Published online January 31, 1991
To evaluate the correlation between clinical and ultrasonographic findings, 79 consecutive brain ultrasonographic examinations were performed in the 50 prematurity and 29 SGA. Statistical significance was not detected about sex ratio, hemoglobin and hematocrit, Apgar score and maternal age between the prematurity and SGA. Incidence of ICH was 66% in the prematurity and 48% in the SGA. According to Papile’s grading system, Grade 1 was...
Vitamin K Dependent Hemorrhagic Disease of the Newborn and Infancy with Intracranial Hemorrhage.
Ji Eun Lee, Pal Dong Kim, Hong Dae Cha, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 1990;33(9):1209-1215.   Published online September 30, 1990
Eight cases of vitamin K dependent hemorrhagic disease of the newborn and infancy with intra- cranial hemorrhage were analysed clinically. Out of 8 cases, 3 cases developed the bleeding within 7 day of life and 5 cases after one month. Two cases had bleeding before initial feeding. Out of 6 cases who were fed before the onset of bleeding, 4 cases had breast feeding. Neurological...
2 Cases of Intracranial Hemorrhae due to Late Hemorrhagic Disease of Infancy due to Vitamin K Deficiency.
Bong Hyune Chung, Hee Jung Seo, Young Hee You, Hyung Sook Lee
Clin Exp Pediatr. 1989;32(12):1726-1731.   Published online December 31, 1989
A clinical study was done on 2 cases under the diagnosis of late hemorrhagic disease of infancy due to Vitamin K dependent factor deficiency. The following results were obtained. The disorder occured most frequently during early infancy (40 days of age & 2 months of age) with male predominance (2 cases all are male). G-I tract, skin, CNS were the most common site...
6 Cases of Intracranial Hemorrhage due to late Late Hemorrhage Disease of Infancy.
Sang Ho Choi, Jae You Choi, Jee Sung Kim, Im Ju Kang
Clin Exp Pediatr. 1988;31(1):106-112.   Published online January 31, 1988
A bleeding syndrome in early infancy due to vitamin K deficiency has been reported sporadically from various parts of world. The syndrome has similarities to hemorrhagic disease of newborn. The main differences are that it is found in an older age group, the pathogenesis is unknown, and intracranial hemorrhage are frequent with a resultant high mortality rate. We have experienced 6 cases of spontaneous...
Case Report
Cranial Ultrasonographic Diagnosis for A Case of intracranial Hemorrhage in Early Infancy due to Vitamin K Deficiency.
Chul Lee, Ki Keun Oh
Clin Exp Pediatr. 1986;29(12):1377-1381.   Published online December 31, 1986
Since the initiation of routine vitamin K prophylaxis in the newborn, the incidence of hemorrhagic disease of the newborn has been dramatically decreased. We report here a case of intracranial hemorrhage due to vitamin K deficiency in a 2-month-old which was diagnosed with cranial ultrasonography. With advent of cranial ultrasonography which is portable, relatively inexpensive and noninvasive, the intracranial hemorrhage is easily confirmed especially as...
A Case of Fatal Intracranial Hemmrhage due to Vitamin K Deficiency.
Yong Sang Yoo, Moon Tae Jeong, Jai Sook Ma, Tai Ju Hwang
Clin Exp Pediatr. 1986;29(1):108-112.   Published online January 31, 1986
The authors experienced a case of massive spontaneous intracranial hemorrhage in anotherwise healthy 21-day-old breast fed male infant. There were no evidences of external trauma. Coagulation studies showed marked prolongation of prothrombin time and partial thromboplastin time. They were significantly corrected after vitamin K administration without clinical improvsment. We concluded that vitamin K deficiency was accounted for the pathogenesis of fatal...
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