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Case Report
Neurology
A long-term subacute sclerosing panencephalitis survivor treated with intraventricular interferon-alpha for 13 years
Minsun Kwak, Hye-Ryun Yeh, Mi-Sun Yum, Hyun-Jin Kim, Su Jeong You, Tae-Sung Ko
Clin Exp Pediatr. 2019;62(3):108-112.   Published online September 18, 2018
Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, and fatal central nervous system disorder resulting from persistent measles virus infection. Long-term data are scarce, with a maximum follow-up period of 10 years. Interferon-alpha (IFN-α) is a protein that exerts its antiviral activity via enhancement of cellular immune response and is reported to be an effective drug for the treatment of...
Original Article
Clinical features of infantile hepatic hemangioendothelioma
Eun Hee Kim, Kyung Nam Koh, Meerim Park, Bo Eun Kim, Ho Joon Im, Jong Jin Seo
Clin Exp Pediatr. 2011;54(6):260-266.   Published online June 30, 2011
Purpose

Infantile hepatic hemangioendothelioma (IHHE) is the most common type of hepatic vascular tumor in infancy. We conducted this study to review our clinical experience of patients with IHHE and to suggest management strategies.

Methods

We retrospectively analyzed the medical records of 23 IHHE patients (10 males, 13 females) treated at the Asan Medical Center between 1996 and 2009.

Results

Median age at diagnosis was...

Case Report
Perivascular epithelioid cell tumor (PEComa) of the ascending colon: the implication of IFN-α2b treatment
Sun Ju Park, Dong Kyun Han, Hee Jo Baek, Sang Young Chung, Jong Hee Nam, Hoon Kook, Tai Ju Hwang
Clin Exp Pediatr. 2010;53(11):975-978.   Published online November 30, 2010

A 7-year-old boy presented with hematochezia and abdominal pain. A 3.7-cm-sized mass was identified in the ascending colon by abdominal computed tomography and colonoscopy. The patient underwent surgical resection. Pathological examination revealed a low-grade perivascular epithelioid cell tumor (PEComa). PEComa in the colon is very rare. Only a few cases have been reported so far. An effective treatment method for...

Original Article
Toll-like receptor 9 expression and interferon-α secretion upon CpG-ODN stimulation in allergic subjects
Man Yong Han, Hye Mi Jee, Hyeong Yoon Kim, Cho Ae Lee, Hyo-Jin Cho, Seong-Gyu Hwang, Kyu-Earn Kim
Clin Exp Pediatr. 2009;52(9):1015-1020.   Published online September 15, 2009

Purpose:The aim of this study is to explore the effect of the Toll-like receptor 9 (TLR9) expressed in plasmacytoid dendritic cells (pDCs) that respond to antigen to Th2 immune deviation in allergic patients. Methods:Subjects consisted of 19 allergic patients and 17 healthy volunteers. Skin prick tests and nasal provocation tests were performed for the two groups. Peripheral blood mononuclear cells (PBMCs)...
Factors Predictive of Response to Interferon-α Therapy in Children with Chronic Hepatitis B
Hong Kwon Kim, Bo Hwa Choi, Kyung Mo Kim, Kyung Hoon Kang, In Seok Lim, Eung Sang Choi
Clin Exp Pediatr. 2000;43(4):514-519.   Published online April 15, 2000
Purpose : The efficacy and safety of interferon-alpha(IFN-α) therapy in children with chronic hepatitis B(CHB) is similar to that of adults. However, little information is available about the predictive factors of response to this therapy in children. The aim of this study was to determine the predictive factors for responsiveness to IFN-α therapy in children with CHB. Methods : The basal...
The Therapeutic Effect of Interferon-alpha Treatment in Children with Chronic Hepatitis B
Il Sang Jeong, Ki Sup Chung
Clin Exp Pediatr. 1997;40(7):955-964.   Published online July 15, 1997
Purpose : The prevalance rate of chronic hepatitis B viral infection in children is high in our contry. We performed a prospective study to evaluate the effectiveness of and the factors predictive of response to interferon-alpha therapy in children with chronic hepatitis B. Methods : Thirty-two children with chronic hepatitis B werew admitted to the Department of Pediatrics, Yonsei University College of Medicine from...
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