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Original Article
Correlation between total air pollutant emissions and incidence of type 1 diabetes in the Russian Federation
Hoon Sung Choi, Jin Taek Kim, Ji-Young Seo, Faina Linkov, Evgeniy Shubnikov, Hong Kyu Lee
Clin Exp Pediatr. 2021;64(10):525-530.   Published online January 18, 2021
Question: Is there a quantitative relationship between air pollutant emissions and the incidence of type 1 diabetes (T1D)?
Finding: The incidence of T1D in each region of the Russian Federation correlated with the total air pollutants emitted each year.
Meaning: These findings suggest that air pollution contributes to the development of T1D.
Changes of clinical characteristics and outcomes in patients with Kawasaki disease over the past 7 years in a single center study
Hye Jin Kang, Gee Na Kim, Hong Ryang Kil
Clin Exp Pediatr. 2013;56(9):389-395.   Published online September 30, 2013

This single-center study was conducted to assess the changes in epidemiological and clinical characteristics and outcomes of patients with Kawasaki disease (KD) over the past 7 years.


This retrospective study included 135 children with KD, admitted to Chungnam National University Hospital, Daejeon, between 2004 and 2005 (group A, n=53) and between 2011 and 2012 (group B, n=82). Medical records were reviewed...

Birth statistics of high birth weight infants (macrosomia) in Korea
Byung-Ho Kang, Joo-Young Moon, Sung-Hoon Chung, Yong-Sung Choi, Kyung-Suk Lee, Ji-Young Chang, Chong-Woo Bae
Clin Exp Pediatr. 2012;55(8):280-285.   Published online August 23, 2012

The authors analyzed the trend from the birth-related statistics of high birth weight infants (HBWIs) over 50 years in Korea from 1960 to 2010.


We used 2 data sources, namely, the hospital units (1960's to 1990's) and Statistics Korea (1993 to 2010). The analyses include the incidence of HBWIs, birth weight distribution, sex ratio, and the relationship of HBWI to maternal...

Recent incidence of congenital heart disease in neonatal care unit of secondary medical center: a single center study
Seon Young Cho, Jin-Hee Oh, Jung Hyun Lee, Jae Young Lee, Soon Ju Lee, Ji Whan Han, Dae Kyun Koh, Chang Kyu Oh
Clin Exp Pediatr. 2012;55(7):232-237.   Published online July 17, 2012

With feasibility in the diagnoses of congenital heart disease (CHD) in the antenatal period, we suspect changes have occurred in its incidence. No data have been reported about the current incidence of simple forms of CHD in Korea. We have attempted to assess the recent incidence and characteristics of CHD in the neonatal care unit of a secondary referral medical...

Incidence and outcome of congenital anomalies of the kidney and urinary tract detected by prenatal ultrasonography: a single center study
Gina Lim, Joo Hoon Lee, Young Seo Park, Kun Seok Kim, Hye-Sung Won
Clin Exp Pediatr. 2009;52(4):464-470.   Published online April 15, 2009
Purpose : This study assessed the incidence and outcome of congenital anomalies of the kidney and urinary tract (CAKUT) detected by prenatal ultrasonography Methods : There were 906 cases of CAKUT detected by prenatal ultrasonography and postnatally confirmed at the Asan Medical Center from October 1989 to October 2007. We investigated the incidence and outcome of these cases by reviewing medical...
Incidence of breast milk jaundice in healthy full-term infants
Yong Ho Yoon, Kyong Eun Choi, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin
Clin Exp Pediatr. 2007;50(11):1072-1077.   Published online November 15, 2007
Purpose : It has been described that the incidence of breastfeeding jaundice is 13% and that of breast milk jaundice is 2%. The incidence in Korea was believed to be higher, but there were no studies to prove this assumption. The purpose of this study was to investigate the incidence of jaundice of healthy breastfed full-term infants in Korea. Methods :...
Clinical and Laboratory Features of Korean Mucopolysaccharidoses (MPSs)
Woo Yun Sohn, Jee Hyun Lee, Kyung Hoon Paik, Eun Kyoung Kwon, Ahn Hee Kim, Dong Kyu Jin
Clin Exp Pediatr. 2005;48(10):1132-1138.   Published online October 15, 2005
Purpose : The mucopolysaccharidoses (MPSs) are a heterogeneous group of lysosomal storage disorders. They are caused by a deficiency of the enzymes involved in the degradation of glycosaminoglycans. Early recognition is important because recombinant enzyme replacement therapy is now available for MPS. We studied the clinical characteristics of 80 MPS children with the object of determining the epidemiological, clinical and...
The Incidence and Risk Factors of Posttraumatic Seizure in Children
Sue Youn, Mi A Lee, Hwang Min Kim, Byung Ho Cha
Clin Exp Pediatr. 2004;47(11):1198-1204.   Published online November 15, 2004
Purpose : The goal of our study was to identify the incidence and clinical, neurophysiological and neuroradiological variables with predictive value for posttraumatic seizure(PTS). Methods : The medical records of 625 children with head traumas under 15-year-old who were admitted to the Wonju Christian Hospital, from January, 1993 to January, 2002 were retrospectively reviewed. Among them, 472 patients were included...
Congenital Heart Disease in Jeju : Postnatal Incidence and Clinical Features
Jung Ha Lee, Gyu Hong Shim, Kyung Sue Shin, Jung Yun Hong, Yeoun Woo Kim, Seong Ho Kim, Chung Il Noh
Clin Exp Pediatr. 2004;47(3):294-303.   Published online March 15, 2004
Purpose : This is a retrospective descriptive study to determine the incidence of congenital heart disease(CHD) in Jeju and to estimate the suitability of the Jeju population as the subject for a regional birth cohort study. Methods : All patients with CHD diagnosed by two dimensional echocardiography in Cheju National University Hospital and Halla General Hospital from January 1999 to...
Risk Factors of Nephrocalcinosis in Very Low Birth Weight(VLBW) Infants
Gyu Hong Shim, Jin A Lee, Yun Jung Shin, Ee Kyung Kim, June Dong Park, Beyong Il Kim, Jung Hwan Choi
Clin Exp Pediatr. 2004;47(3):275-281.   Published online March 15, 2004
Purpose : Nephrocalcinosis in very low birth weight(VLBW) infants were known to be caused by a longer duration of furosemide use. However, etiologies, pathogenesis and risk factors remain unclear. Therefore, we examined the incidence and risk factors of nephrocalcinosis in VLBW infants retrospectively. Methods : Inborn babies of birth weights less than 1,500 gm were examined retrospectively. Data were reviewed on...
A Prospective Epidemiological Study on Birth Defects : A Community Based Pilot Study
Hyon Ju Kim, Yeon Kyeoung Kim, Dae Kyun Koh, Jong Hyun Kim, Bo Won Choi
Clin Exp Pediatr. 2000;43(6):738-745.   Published online June 15, 2000
Purpose : This prospective pilot study is a part of the Korean NIH’s effort to characterize congenital anomalies and genetic disorders in Korea and to establish a National Genetic Database. Methods : This population-based study was conducted at all hospitals that deliver in the province of Suwon; a total of 39 hospitals from May 1, 1997 to April 30, 1999 for...
Incidence of Congenital Heart Disease in Neonate by Color Doppler Echocardiography
Tae Chan Kwon, Joon Sik Kim, Sang Lak Lee, Myung Sung Kim, Geun Soo Park, Chun Soo Kim, In Joo Kim, Bin Ahn
Clin Exp Pediatr. 1998;41(3):363-368.   Published online March 15, 1998
Purpose : Many reports exist about the frequency of congenital heart disease(CHD) in the world, but according to the definition of CHD and subjects of study group, many differences existed between the reports. We conducted this study to evaluate the incidence and frequency of CHD by color Doppler echocardiography in neonate, and to suggest a preliminary model of incidence of...
A Study on Menarchel Age and Monthly Incidence of School Girls in Ansan
Hyung Seok Kim, Jae Yong Kim, Young Kyu Shin, Sang Hee Park, Young Chang Tockgo
Clin Exp Pediatr. 1997;40(4):458-463.   Published online April 15, 1997
Purpose : Menarche is an important life event, making the transition from childhood to early womanhood. It is a significant physical and physiological event that adolescent girls feel sexual identity and it affects on psychological development. The onset of menstruation is considered a practical indication of sexual maturity in girls. On a population level, mean menarcheal age is considered to...
Changes in MaternalAge and the Incidence of Down Syndrome
Chang Weon Oh, Sung Su Lim, Ki Bok Kim, Won Jin Kee
Clin Exp Pediatr. 1996;39(11):1512-1519.   Published online November 15, 1996
Purpose : The incidence of Down syndrome, the most common chromosoaml anomaly, increases with the advanced maternal age. Recently, however, the incidence of Down symdrome was reported to have decreased with wide acceptance of prenatal diagnosis and planned parenthood, prompting us to re-evaluate the incidence of Down syndrome in relation to changes in maternal age. Methods : Subjected to study were 296 Down cases: 26...
Incidenceand Risk Factorsof the Retinopathy of Prematurity
June Dong Park, Jung Hae Kweon, Woong Heum Kim, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun, Sang In Khwarg, Young Suk Yu
Clin Exp Pediatr. 1996;39(3):326-337.   Published online March 15, 1996
Purpose : Retinopathy of prematurity(ROP) continues to be a serious problem in infants who survived with neonatal intensive care. Nevertheless, there is neither available data about the incidence of ROP which may be the basis of the epidemiology, nor analysis of the risk factors of ROP in Korea. The purpose of this retrospective study was to evaluate the incidence of...
Echocardiographic Evaluation of the Natural Processes in Uncomplicated Ventricular Septal Defect
Hyang Suk Yoon, Du Young Choi
Accepted January 1, 1970  
We studied, with echocardiography as a main tool, the natural processes of 211 patients with uncomplicated ventricular septal defect(VSD)(incidence, 5.33 per 1,000 live births); 146(69.2%) had a perimembranous VSD and 32 (15.2%) had a subarterial, 25(11.8%) had a muscular type of VSD. Cumulative rate of spontaneous closure was 26.1%. In the closure processes, about three-fourth of perimembranous VSd showed a...
Original Article
Incidence and Perinatal Risk Factors of Respiratory Distress Syndrome of Newborn
Yun Sil Chang, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1994;37(8):1065-1077.   Published online August 15, 1994
Over a continuous 4-year period, from January 1989 till December 1992, 7,100 infants were born in Department of Obstetrics and admitted to Nursery or Neonatal Intensive Care Unit of Department of Pediatrics of Seoul National University Children's Hospital. Among them, 126 cases were diagnosed as respiratory distress syndrome (RDS) of newborn. The total incidence of RDS among all the newborns(inborn)was 1.77%....
Incidence Estimation of Leukemia among Korean Children
Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Yoon-Ok Ahn
Clin Exp Pediatr. 1992;35(1):80-87.   Published online January 15, 1992
Leukemia is a neoplasm arising from the malignant transformation of hematopoietic cells. The incidence data of leukemia have not been available for Korean as a whole. The present study was therefore undertaken in order to estimate the incidence of childhood leukemia among Korean. The study population of this investigation was the beneficiaries of the Korea Medical Insurance Corporation(KMIC) during the period...
Clinical Analysis on Childhood Accidents.
Won Seop Kim, Youn Jin Hong, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1990;33(12):1631-1638.   Published online December 31, 1990
We carried out a stastical & clinical analysis on 2,593 cases of childhood accidents visiting emergancy room of National Medical Center during last 5 years, from Jan. 1, 1984 to Dec. 31, 1988. The results were as follows: 1) The total percent of accidents among EMR visitors showed 6% increase in 1988 compared to that of in 1984 2) The most common type of accidents was trauma...
Incidence of Exercise-Induced Asthma in One Elementary School Children.
Eung Won Park, Dong Uk Kim, Won Ho Choi, Kwang Woo Kim
Clin Exp Pediatr. 1990;33(11):1557-1561.   Published online November 30, 1990
This study was conducted to find out the incidence of exercise-induced asthma in pediatric population at Pohang in Korea. We selected an elementary school near pohang. The total number of the elementary school children except who was ill at that time, was 631. They all took pulmonary function test with Wright’s Peak Flow Meter before and after exercise. The study was done from 21st...
A Clinical Study on Children with Acute Glomerulonephritis.
Jeong Ok Kim, Son Moon Shin, Yong Hoon Park
Clin Exp Pediatr. 1989;32(6):779-788.   Published online June 30, 1989
A clinical observation has been made on 111 children with acute glomerulonephritis who were admitted to Pediatric Department of Yeungnam University Hospital during 5 years period from June 1, 1983 to May 31, 1988. The incidence of acute glomerulonephritis among hospitalized patients was 1.59% and the annual incidence was decreased markedly after June 1986. Peak incidence was noticed in the wintertime from November to January...
A Clinical Observation on the Incidence of Childhood Leukemia.
Hyo Seop Ahn, Il Soo Ha, Soon Ki Kim, Hoan Jong Lee, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):841-849.   Published online July 31, 1988
We have analysed the type, age, sex, initial hematologic values and cell markers in 295 children, who had been diagnosed as leukemia at the department of pediatrics, Seoul National University Hospital, from Jan. 1983 to Dec. 1987. The patients were composed of 197 cases (66.8%) of ALL, 82 cases (27.7%) of ANLL and 16 cases (5.5%) of CML. FAB subclassification have been done in...
A Study of Frequency of Malignant Tumors in Children.
Yang Dong Park, Eun Sook Choi, Hyun Gi Jung, Jae Sun Park
Clin Exp Pediatr. 1986;29(10):1130-1137.   Published online October 31, 1986
315 cases of malignant tumors under 15 years of age who were admitted to the Gospel Hospital from January 1975 to December 1984 were analysed and following results were obtained. 1) The incidence of malignances in all admitted child patient was 3.39%. 2) Childhood malignant tumors were more frequently occured in the age group of 0〜5 years. The more prevalent tumors for the...
Statistical Analysis of The Tomors Below 20 Years of Age.
Sang Ho Park, Kyu Chul Choi, Yong Mook Choi, Chang Il Ahn
Clin Exp Pediatr. 1986;29(8):888-897.   Published online August 31, 1986
Total 460 cases of benign and malignant tumors below 20 years of age who admitted to Kyung Hee University Hospital for 5 years from January 1980 to December 1984 were clinically analized and the following results were obtained.1) Among 460 benign and malignant tumors, malignant tumors were 201 cases(43.7%) and benign tumors were 259 cases(56.3%). 2) The male to female incidence ratio was...
A Study of Frequency in Malignant Tumors of Children.
Myung Ho Lee, Seong Ja Jeon
Clin Exp Pediatr. 1984;27(7):711-717.   Published online July 31, 1984
We obtained following results by analysis of 355 cases of malignant tumors in patients under 15 years of age who were admitted to the Chonju Presbyterian Medical Center from January 1971 to December 1982. The diagnosis was confirmed by pathologic studies. 1)The most common malignant tumor was leukemia(44.9%). The next in order were lymphoma (14.9%), brain tumor(7. 0%), Wilms tumor(7.0%),...
Relative Incidence of Various Acute Viral Hepatitis in Childhood.
Young Hoon Song, Gwi Jong Choi, Heung Jae Lee, Keung Soo Lee
Clin Exp Pediatr. 1984;27(6):563-569.   Published online June 30, 1984
This report was conducted to estimate the relative incidence of acute viral hepatitis (all were under 15 years of age. Who were admitted to the Pediatric Department, Hanyang University Hospital during the period from March 1982 to August 1983 were evaluated. The following results were obtained. 1)The sex ratio of of male to female was 1.34 : 1. 2)The incidence...
Role of Enterotoxogenic E.Coli in Acute Diarrhea of Childhood in Korea.
Kwang Wook Ko, Jeong Kee Seo, Woo Hyun Chang, Moon Kyo Kim, Nam Ung Yang, Myoung Sik Choi
Clin Exp Pediatr. 1983;26(10):949-958.   Published online October 31, 1983
To determine the role of enterotoxigenic Escherichia coli in diarrheal disease of non-hosp- italized children living in Korea, stool specimens were collected from 330 patients with dia- rrhea and 68 age and sex matched control. Sixty-eight healthy children and 330 diarrheal patients, who visited three private clinics and one municipal hospital in Inchon City, were tested to detect the production of Escherichia coli enterotoxin...
Supracristal Ventricular Suptal Defect in Korean.
Hee Ju Kim, Son Moon Shin, Yong Soo Yoon, Chang Yee Hong, Yung Kyoon Lee
Clin Exp Pediatr. 1983;26(7):631-639.   Published online July 31, 1983
Supracristal ventricular septal defect has engendered an interest in recent years because of the racial difference in its incidence and the unusually high association of the aortic valve abnormalities. The relative incidence of supracristal ventricular septal defect was studied in Korean. During the period of eight years from January 1974 to December 1981, 119 cases(27.6%) of supracristal type were noted among 431 cases of...
A Study on Frequency of Malignant Tumors in Children.
Chang Yee Hong, Hyo Seop Ahn, Byung Kwan Sohn, Son Moon Shin, In Sil Lee
Clin Exp Pediatr. 1983;26(5):489-498.   Published online May 31, 1983
Five hundred and thirty-nine cases of malignant tumors (excluding leukemia) under 15 years of age who were admitted to Seoul National University Hospital from January 1967 to December 1981 were reviewed and analysed. Three hundred and ninety-nine cases of leukemia were seen during the same period and total 938 cases of malignancies including leukemia were observed. 1. The frequency of malignant tumors...
A Clinical Study of Tic Disorder in Korea.
Kang E Hong
Clin Exp Pediatr. 1981;24(3):198-208.   Published online March 15, 1981
30 patients diagnosed as having tic disorder at the Child Psychiatry clinic of Seoul National University Hospital were studied in terms of sex, age, onset, precipitating factors,characteristics of the patients and family dynamics. A short term follow up study wascarried out regarding the outcomes of the symptom and the changes in attitudes and beha-viors of patients and parents. The results...
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