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Review Article
Oncology
Update on infantile hemangioma
Hye Lim Jung
Clin Exp Pediatr. 2021;64(11):559-572.   Published online May 26, 2021
· Infantile hemangiomas (IHs) are the most common benign vascular tumors, occurring in 5%–10% of infants.
· IHs are characteristically not present at birth but are usually diagnosed at 1–4 weeks of age, rapidly proliferate until 5 months of age, and then spontaneously involute.
· High-risk IHs (10%) require early treatment from 1 month of age.
· Oral propranolol, a nonselective beta-blocker, is the first-line treatment for IHs.
Original Article
A prospective study to assess the efficacy and safety of oral propranolol as first-line treatment for infantile superficial hemangioma
Yeong Ju Yun, Yun Hee Gyon, Sohyoung Yang, Youn Kyung Lee, Joohyun Park, Meerim Park
Clin Exp Pediatr. 2015;58(12):484-490.   Published online December 22, 2015
Purpose

To determine the efficacy and safety of oral propranolol as a first-line treatment for superficially located infantile hemangioma (IH) and propose an assessment tool to measure treatment response.

Methods

Patients with superficial IH under 1 year of age were prospectively recruited between May 2012 and December 2013 at the Department of Pediatrics of Chungbuk National University Hospital. Propranolol was administered to 12...

Case Report
Gastrointestinal hemangioma in childhood: a rare cause of gastrointestinal bleeding
Eon Chul Han, Soo-Hong Kim, Hyun-Young Kim, Sung-Eun Jung, Kwi-Won Park
Clin Exp Pediatr. 2014;57(5):245-249.   Published online May 31, 2014

Gastrointestinal (GI) hemangiomas are relatively rare benign vascular tumors. The choice of an appropriate diagnostic method depends on patient age, anatomic location, and presenting symptoms. However, GI hemangiomas are not a common suspected cause of GI bleeding in children because of their rarity. Based on medical history, laboratory results, and imaging study findings, the patient could be treated with either...

A girl with sternal malformation/vascular dysplasia association
Na Yong Lee, Hye Kyung Cho, Kyung-Hyo Kim, Eun Ae Park
Clin Exp Pediatr. 2013;56(3):135-138.   Published online March 18, 2013

Sternal malformation/vascular dysplasia association is a rare congenital dysmorphology, which has not yet been reported in Korea. Its typical clinical features include a sternal cleft covered with atrophic skin, a median abdominal raphe extending from the sternal defect to the umbilicus, and cutaneous craniofacial hemangiomata. We report a case of a full-term newborn who presented with no anomalies at birth,...

Original Article
Successful and safe treatment of hemangioma with oral propranolol in a single institution
Sun Hee Chung, Dong Hyuk Park, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park, Hong Hoe Koo
Clin Exp Pediatr. 2012;55(5):164-170.   Published online May 21, 2012
Purpose

Dramatic improvement of hemangioma to propranolol has been recently reported; however, details on dose and duration of treatment, potential risks, and monitoring have not been determined. The objective of this study is to describe and analyze the use of propranolol as a first-line treatment or as a single therapy in management of complicated hemangioma.

Methods

A retrospective chart review of eight patients...

Case Report
PHACE association with intracranial, oropharyngeal hemangiomas, and an atypical patent ductus arteriosus arising from the tortuous left subclavian artery in a premature infant
Do-Hyun Kim, Jang Hwan Choi, Jung Ha Lee, Hee Sup Kim
Clin Exp Pediatr. 2012;55(1):29-33.   Published online January 31, 2012

PHACE association is a rare neurocutaneous condition in which facial hemangiomas associate with a spectrum of posterior fossa malformations, arterial cerebrovascular anomalies, cardiovascular anomalies, and eye anomalies. We reported a case of PHACE association in a premature infant showing facial, intracranial, and oropharyngeal hemangiomas with evidence of the Dandy-Walker variant and complicated cardiovascular anomalies, including a right-sided aortic arch and...

Cerebellar cavernous hemangioma that presented with posterior neck myalgia
Seung-Ah Baek, Kyung-Lim Yoon, Kye-Shik Shim, Jae-Seung Bang
Clin Exp Pediatr. 2008;51(12):1363-1367.   Published online December 15, 2008
Cavernous hemangioma can occur in the entire brain but rarely in cerebellum, especially in the pediatric age group. Headache, seizure, gait disturbance, recurrent bleeding may be seen. This tumor is a relatively benign condition but if the lesion located in the posterior fossa or the brain stem bleeds, irreversible brain damage may occur because of its restrictive space. Moreover, it...
Successful Management with Vincristine after Failure of Prednisolone Therapy for Diffuse Neonatal Hemangiomatosis
Hak-Sung Lee, Soon-Young Heo, Won-Duck Kim
Clin Exp Pediatr. 2005;48(9):1004-1008.   Published online September 15, 2005
Hemangiomas are the most common benign tumors of infancy. Fifteen to 30% of these patients have multiple hemangiomas. Diffuse neonatal hemangiomatosis (DNH) is a disease that often has a fatal outcome if left untreated, and is characterized by multiple cutaneous and visceral hemangiomas. Corticosteroids are the commonly accepted first line treatment, but if no effect is seen, further treatment is...
One Case of Maffucco's Syndrome with Testicular Teratoma
Seung Mo Park, Duk Hi Kim, Ho Seong Kim
Clin Exp Pediatr. 1994;37(8):1162-1168.   Published online August 15, 1994
Maffucci's syndrome is a very rare, congenital and non-hereditary mesodermal dysplasia manifested by multiple enchondromas and soft tissue hemangiomas. Since Maffucci had reported this syndrome in 1881, there have been more than 100 cases reported, and also there has been reported that Maffuddi's syndrome has various interstitial tumor. However there hasn't been any report about Maffucci's syndrome with testicular teratoma....
Original Article
Clinical study of Kasabach-Merritt syndrome.
Eun Jung Bae, Young Ah Lee, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(3):371-379.   Published online March 31, 1991
A retrospective analysis of clinical findings in 20 patients with Kasabach-Merritt syndrome who visited Department of Pediatrics, Seoul National University Hospital from January, 1979 to June, 1990 was performed. The average age of occurrence was 6.4 month and male to female ratio was 1: 1.2. The mean size of hemangioma was 11.0x8.5 cm and the locations were cutanous in 18 (extrem- ities 5, trunk...
The Two Cases of Klippel-Trenaunay Weber Syndrome.
Man Chul Ha, In Hun Lee, Yong Tak Lim, Hi Joo Chun, Hi Ju Park, Chan Yung Kim
Clin Exp Pediatr. 1988;31(3):391-397.   Published online March 31, 1988
We experienced two cases of Klippel-Trenaunay-Weber Syndrome in 13 years old boy and 10 years old girl. They had shown large nevus flammeus, varicose veins, soft tissue and bong hypatrophy. In angrogam and venogram capillary and venous hemangioma were noted, but we could not find arteriovenous filstula. We report two cases of Klippel-Trenaunay-Weber Syndrome with review of literature.
Case Report
A Case of Blue Rubber Bleb Nevus Syndrome.
Kwang Soo Oh, Soon Kook Choi, San Ho Kim, Bock Keun Kee, Hyung Sun Sohn, Seok Don Park
Clin Exp Pediatr. 1986;29(12):1372-1376.   Published online December 31, 1986
The Blue Rubber Bleb Nevus Syndrome is defined as rarely occuring hemangioma of the skin and gastrointestinal tract, with intestinal hemorrhage. Bean in 1958 gave the name Blue Rubber Bleb Nevus (BRBN) to a variant of bluish hemangiomas of the gastrointestinal tract which causes bleeding, which had been described for the first time by Gascoyen. We experienced a case of Blue Rubber Bleb Nevus...
A Case of Klippel-Trenaunay-Parkes-Weber Syundrom and the Review of Literatures on 14 Cases Reported in Korea.
Kap Seoung Kim, Hyun Young Ahn, Young Yoon Choi
Clin Exp Pediatr. 1984;27(9):935-940.   Published online September 30, 1984
We experienced a case of Klippel-Trenaunay-Parkes-Weber Syndrome in a 6 year old boy who had large hemangioma on the left extremities and trunk, varicose veins, soft and bony hypertrophy, vascular variation in flushing aortogram and enlarged left kidney in abdominal C-T. We report this with the review of literatures on 14 cases of Klippel-Trenaunay-Parkes-Weber Syndrome which were reported in Korea.
A Case of Klippel-Trenaunary-Weber Syndrome.
Do Seung Lee, Dae Yong Hwang, Jeong Sick Min, Jae Sun Park
Clin Exp Pediatr. 1983;26(5):516-520.   Published online May 31, 1983
We report a case of Klippel-Trenaunay-Weber Syndrome in a 12 years old boy who had large port-wine hemangioma, soft tissue & bony hypertrophy and varicose veins on the lower leg. On the skin lesion, there are several black papules & crops of skin colored eruptions which were found out microscopically to be intraepidermal bleeding focuses & harmatomatous change of squamous cells into sebaceous cells...
A Case of Kasabach-Merritt Syndrome.
Young Yoon choi, young Hwa park, Hyung Suk byun, Chull sohn, Ae Sook kim
Clin Exp Pediatr. 1982;25(3):310-316.   Published online March 31, 1982
Hemangioma associated with thrombocytopenia is a relatively rare occurrence. The first case was described in 1940 by Kasabach and Merritt, who used X-ray therapy as radium implants in the treatment of hemangioma on the affected infant. The tumor regressed and the platelet count rose to normal. Mechanical sequestration of platelets in the vascular channels of the hemangioma is believed to be the mechanism of...
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